132 research outputs found
Comparison of rivaroxaban and low molecular weight heparin in the treatment of cancer-associated venous thromboembolism: A Swedish national population-based register study
No full textBackground Treating cancer-associated venous thromboembolism (CAT) with anticoagulation prevents recurrent venous thromboembolism (rVTE), but increases bleeding risk. Objectives To compare incidence of rVTE, major bleeding, and all-cause mortality for rivaroxaban versus low molecular weight heparin (LMWH) in patients with CAT. Methods We developed a cohort study using Swedish national registers 2013–2019. Patients with CAT (venous thromboembolism within 6 months of cancer diagnosis) were included. Those with other indications or with high bleeding risk cancers were excluded (according to guidelines). Follow-up was from index-CAT until outcome, death, emigration, or end of study. Incidence rates (IR) per 1000 person-years with 95% confidence interval (CI) and propensity score overlap-weighted hazard ratios (HRs) for rivaroxaban versus LMWH were estimated. Results We included 283 patients on rivaroxaban and 5181 on LMWH. The IR for rVTE was 68.7 (95% CI 40.0–109.9) for rivaroxaban, compared with 91.6 (95% CI 81.9–102.0) for LMWH, with adjusted HR 0.77 (95% CI 0.43–1.35). The IR for major bleeding was 23.5 (95% CI 8.6–51.1) for rivaroxaban versus 49.2 (95% CI 42.3–56.9) for LMWH, with adjusted HR 0.62 (95% CI 0.26–1.49). The IR for all-cause mortality was 146.8 (95% CI 103.9–201.5) for rivaroxaban and 565.6 (95% CI 541.8–590.2) for LMWH with adjusted HR 0.48 (95% CI 0.34–0.67). Conclusions Rivaroxaban performed similarly to LMWH for patients with CAT for rVTE and major bleeding. An all-cause mortality benefit was observed for rivaroxaban which potentially may be attributed to residual confounding.Fil: Linder, Marie. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Ekbom, Anders. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Brobert, Gunnar. Consultant for Bayer AG; AlemaniaFil: Vogtländer, Kai. Bayer AG; AlemaniaFil: Balabanova, Yanina. Bayer AG; AlemaniaFil: Becattini, Cecilia. Università di Perugia; ItaliaFil: Carrier, Marc. University of Ottawa; CanadáFil: Cohen, Alexander T.. Kings College London (kcl);Fil: Coleman, Craig I.. University of Connecticut; Estados UnidosFil: Khorana, Alok A.. Cleveland Clinic and Case Comprehensive Cancer Center; Estados UnidosFil: Lee, Agnes Y. Y.. BC Cancer; Canadá. University of British Columbia; CanadáFil: Psaroudakis, George. Bayer AG; AlemaniaFil: Abdelgawwad, Khaled. Bayer AG; AlemaniaFil: Rivera, Marcela. Consultant for Bayer AG; AlemaniaFil: Schaefer, Bernhard. Bayer AG; AlemaniaFil: Giunta, Diego Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Karolinska Huddinge Hospital. Karolinska Institutet; Sueci
Survival of Civilian and Prisoner Drug-Sensitive, Multi- and Extensive Drug- Resistant Tuberculosis Cohorts Prospectively Followed in Russia
No full textThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Tuberculosis in Samara, Russia : diagnosis, epidemiology and risk factors for drug resistance
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Trajectories through the intertextual paths of Sumido en Verde Temblor : towards a description of a territorial author’ reading and writing practices
No full textFil: De Campos, Yanina Fátima. Universidad Nacional de Misiones. Facultad de Humanidades y Ciencias Sociales; Argentina.La intertextualidad se presta al juego creativo de autor como una forma provocativa y seductora del lenguaje literario; al mismo tiempo, se (re)presenta en nuestros recorridos de análisis críticos y refl exivos de la escritura de Rodolfo Nicolás Capaccio. Sumido en verde temblor –mapa y no frontera estable- murmura ecos de otras voces interculturales que nos sugieren describir las prácticas de lectura y escritura de su autor territorial, relacionadas con la tópica de la “Conquista” y el “Descubrimiento” de América. Además, propone una entrada posible a su polifacético proyecto estético y a su particular archivo de escritor en construcción.
En este sentido, mediante el continuo afán de refractar nuestro deseo en diálogo perpetuo con el de los lectores, buscamos recorrer un trayecto de difusión y transferencia que nos permita avanzar en nuestro trabajo como investigadores de la Universidad pública. Con ello, intentamos situar y desplazar en escena la libertad del significante que se despliega en toda nueva lectura y escritura reflexiva y que busca desencadenar un nuevo Texto capaz de de-escribir la práctica de la escritura (Cfr. Barthes, 2002: 106-108).Intertextuality lends itself to the author’s creative play as a provocative and seductive form of literary language; at the same time, it is (re)presented in our tour through the critical and refl ective analysis of Rodolfo Nicolás Capaccio’s writing. Sumido en verde temblor –map, not a steady frontier–, murmurs echoes of other intercultural voices that suggest us to describe its territorial author’ practices of reading and writing, which are related to the topic of the “Conquest” and “Discovery” of America. In addition, it proposes a possible entry to the author´s multifaceted/versatile aesthetic project and to his particular archive of writer under construction. In this sense, through the constant ambition to refract our desire in perpetual dialogue with that of the readers, we seek to follow a path of diff usion/dissemination and transference that allows us to advance in our work as researchers of the public university. With this, we try to situate and move on the scene the signifi er’s freedom that unfolds in every new reading and refl ective writing that seeks to trigger a new Text capable of de writing the practice of writing (Barthes, 2002: 106- 108)
Emerg Infect Dis
No full textA high prevalence of tuberculosis (TB) isolates that are genetically homogenous and from the Beijing family has been reported in Russia. To map TB transmission caused by these strains, new genotyping systems are needed. Mycobacterial interspersed repetitive units (MIRUs) offer the possibility of rapid PCR-based typing with comparable discrimination to IS6110 restriction fragment length polymorphism techniques. Spoligotyping and detection of IS6110 insertion in the dnaA-dnaN region were used to identify Beijing strains in 187 Mycobacterium tuberculosis isolates from Samara, Russia. The Beijing isolates were analyzed by using 12-MIRU and 3-exact tandem repeats (ETR) loci and by an expanded set of 10 additional variable number tandem repeats loci. The expanded set of 25 MIRUs provided better discrimination than the original set of 15 (Hunter-Gaston diversity index 0.870 vs. 0.625). Loci MIRU 26, 1982, and 3232 were the most polymorphic in Beijing isolates
La quotidienneté comme champ d’action et discours d’autorité du socialisme tardif : l’exemple du récit de Grigori Gorine Contribution à la question de Derjavine (K voprosu o Deržavine)
No full textThe article focuses on the clash Soviet everydayness and authoritative discourse in the humorous short story “ K voprosu o Derzhavine ” by Grigorii Gorin , Soviet / Russian writer of the Era of Stagnation . Placing the ‘ sacred ’ figure of Russian classicist poet Gavrila Derzhavin into the sphere of the late Soviet quotidian the author , through the naïve narrator ’ s voice , dilutes the strict line between the ‘ high ’ and the ‘ low ’. Gorin necessitates a dialogue between the seemingly invincible Soviet bureaucratic authority (the director of the plant ) and the representative of the supposed ‘ dictatorship of the proletariat ’ (the worker of the plant ) whose communication is effectively mediated by the professor , the representative of the Soviet intelligentsia . The study suggests that using the elements of skaz and theatricality Gorin depicts Soviet quotidian as arena for debasing moves towards the authoritative discourse on the part of ordinary Soviet citizens , offering a potentiality of the transformative action.Mouton Yanina. La quotidienneté comme champ d’action et discours d’autorité du socialisme tardif : l’exemple du récit de Grigori Gorine Contribution à la question de Derjavine (K voprosu o Deržavine). In: Revue Russe n°51, 2018. Russie, la force des faibles. pp. 113-120
Clinical features, diagnosis, and management of multiple drug-resistant tuberculosis since 2002.
No full textPURPOSE OF REVIEW: Multiple drug-resistant tuberculosis is increasing globally, particularly in Eastern Europe. This review summarizes advances in our understanding of the epidemiology, diagnosis, and treatment of MDRTB in 2002-2003. RECENT FINDINGS: The annual incidence of multiple drug-resistant tuberculosis globally is unknown because systematic drug resistance data have been produced from only 60 countries internationally. Nevertheless, countries with effective tuberculosis programs see approximately 1% multiple drug-resistant tuberculosis among new cases annually. Hot spots with high rates such as countries of the former Soviet Union exist, and modeling of existing data suggests that between 250,000 and 500,000 new MDRTB cases occur globally. Unfortunately, mortality from multiple drug-resistant tuberculosis, particularly with HIV co-infection, remains high, and the global economic costs are also substantial. Research has produced many rapid and novel diagnostic methods for multiple drug-resistant tuberculosis, but culture-based methods remain the mainstay of analyzing resistance to drugs other than isoniazid and rifampicin. Treatment of multiple drug-resistant tuberculosis is prolonged, and survival requires therapy with at least three agents to which the bacteria are susceptible. Individualized therapy forms the gold standard of treatment, but the high laboratory costs associated with this approach have led to studies of standardized treatment in middle-/low-income countries. Studies in Peru examined both approaches with comparable success. Nevertheless, even standardized treatment requires an accurate survey of drug resistance and an understanding and correction of the causes of the high rates of multiple drug-resistant tuberculosis. SUMMARY: The global rates of multiple drug-resistant tuberculosis are unknown. Rapid and early diagnosis of multiple drug-resistant tuberculosis improves survival and is of a public health benefit. Treatment requires prolonged effective combination chemotherapy
Enhanced energy deposition efficiency of glow discharge electron beams for metal surface treatment
No full textThe energy deposition efficiency and focal spot dynamics of electron beams produced by pulsed cold-cathode high-voltage glow discharges for metal surface treatment are investigated for two different cathode geometries. A concave cathode geometry in which the focusing is dominated by the convergence of the electric field lines in the cathode fall region is compared with a flat cathode in which the focusing is exclusively caused by the self-generated magnetic field. Results of the treatment of AISI 4140 carbon steel samples show that the concave cathode geometry significantly increases the efficiency, reduces the threshold power necessary for melting, and is less sensitive to variations in the discharge parameters and sample position. The results of numerical modeling indicate that the observed increase in efficiency is caused by the longer persistence of the focal spot on the sample. The model can be used to predict the discharge parameters required for a desired treatment.Fil: Mingolo, Nelida. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física; ArgentinaFil: Cesa, Yanina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física; ArgentinaFil: Martínez, Oscar Eduardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Etcheverry, Javier Ignacio. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rocca, Jorge J.. State University of Colorado - Fort Collins; Estados Unido
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No full textA perda progressiva de células dopaminérgicas nos gânglios da base é característica patológica da doença de Parkinson (DP), que resulta na disfunção de respostas automáticas motoras. O estudo se baseia no fato de que as disfunções motoras, de automaticidade e cognitivas compartilham a via córtico-estriatal, onde acontece esta perda dopaminérgica. Estudos dos componentes desta via detectaram ativação do estriato durante o aprendizado implícito. Por outro lado, estudos que mediram o tempo de reação em participantes com DP em diferentes tarefas revelaram correlações entre desempenho motor e aquisição implícita do conhecimento. O objetivo principal do presente trabalho é avaliar o aprendizado implícito de sequências probabilísticas na Doença de ParkinsonThe progressive loss of dopaminergic cells at the basal ganglia is a pathological aspect of Parkinsons Disease (PD) that results in the dysfunction of motor automatic responses. The present study is based on the fact that motor, automatic, and cognitive dysfunctions share the cortical striatum pathway, which suffers from dopaminergic loss. Past studies of this pathway components have shown the striatum activation during implicit learning. Although, studies that measured reaction time in individuals with PD at different tasks revealed correlations between motor performance and implicit knowledge acquisition. Our main goal is to evaluate the implicit learning of probabilistic sequences on Parkinsons Diseas
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