424 research outputs found
Cations derived from proton sponge : modification of halide ion coordination chemistry through intermolecular interactions
No full text1 online resource (x, 46 pages) : illustrations (some colour), graphsIncludes abstract.Includes bibliographical references (pages 43-46).A family of 1,3-bis(dimethylamino)napthalene salts have been prepared, starting from 1,3-bis(dimethylamino)naphthalene (Proton Sponge®). When protonated, these molecules have weak hydrogen bonding interactions with anions due to the bridging of a proton between the two dimethylamino groups. Theis bridging removes the best hydrogen bonding sire and reduces interactions between the cation and the anion. This increases the basicity of the anion allowing for a more accurate representation of a naked anion. This study investigates halides as anions and their subsequent basicity and reactivity toward other small molecules.</p
Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24
No full textProteasome dysfunction can lead to autoinflammatory disease associated with elevated type I interferon (IFN-αβ) and NF-κB signaling; however, the innate immune pathway driving this is currently unknown. Here, we identified protein kinase R (PKR) as an innate immune sensor for proteotoxic stress. PKR activation was observed in cellular models of decreased proteasome function and in multiple cell types from patients with proteasome-associated autoinflammatory disease (PRAAS). Furthermore, genetic deletion or small-molecule inhibition of PKR in vitro ameliorated inflammation driven by proteasome deficiency. In vivo, proteasome inhibitor-induced inflammatory gene transcription was blunted in PKR-deficient mice compared with littermate controls. PKR also acted as a rheostat for proteotoxic stress by triggering phosphorylation of eIF2α, which can prevent the translation of new proteins to restore homeostasis. Although traditionally known as a sensor of RNA, under conditions of proteasome dysfunction, PKR sensed the cytoplasmic accumulation of a known interactor, interleukin-24 (IL-24). When misfolded IL-24 egress into the cytosol was blocked by inhibition of the endoplasmic reticulum-associated degradation pathway, PKR activation and subsequent inflammatory signaling were blunted. Cytokines such as IL-24 are normally secreted from cells; therefore, cytoplasmic accumulation of IL-24 represents an internal danger-associated molecular pattern. Thus, we have identified a mechanism by which proteotoxic stress is detected, causing inflammation observed in the disease PRAAS.Sophia Davidson, Chien-Hsiung Yu, Annemarie Steiner, Frederic Ebstein, Paul J. Baker, Valentina Jarur-Chamy, Katja Hrovat Schaale, Pawat Laohamonthonkul, Klara Long, Dale J. Calleja, Cassandra R. Harapas, Katherine R. Balka, Jacob Mitchell, Jacob T. Jackson, Niall D. Geohegan, Fiona Moghaddas, Kelly L. Rogers, Katrin D. Mayer-Barber, Adriana A. De Jesus, Dominic De Nardo, Benjamin T. Kile, Anthony J. Sadler, M. Cecilia Poli, Elke Kruger, Raphaela Goldbach Mansky and Seth L. Master
The life and works of James Miller, 1704-1744, with particular reference to the satiric content of his poetry and plays.
No full textPhDJames Miller was born the son of a Dorset rector in 1704. He
was himself ordained, but acquired no benefice until just before his
early death, probably because of a scathing portrayal of the Bishop
of London in one of his verse satires. At Oxford he wrote a vivacious
comedy of humours, set in the University. Its production in 1730
began his dramatic career, at a time when the number of London
theatres had just doubled, and new dramatic forms were being invented.
In 1731 his poem Harlequin-Horace, a witty inversion of
the Ars Poetica, attacked pantomime and opera, but also painted a
lively portrait of the entire theatrical world, in the tradition of
the Dunciad.
After collaborating in a translation of Moliere's works Miller
wrote two plays based on this author. Of all his dramatic works
these were the most successful with his contemporaries, and were
followed by a modernisation of Much Ado, and a ballad-opera adapted
from an afterpiece by Jean-Baptiste Rousseau, and rendered highly
topical. Miller made similar use of a recent French comedy showing
a Red Indian's reactions to civilisation, a satiric "fable" by Walsh
and Voltaire's Mahomet. A large quantity of original material was
incorporated into most of these, and this is generally satirical in
nature. The Indian is made to voice almost egalitarian sentiments.
An afterpiece, "The Camp Visitants", satirised military inaction
in the war, and was apparently banned. The manuscripts of the six
plays produced after the Licensing Act bear the examiner's deletions,
and illustrate the nature of the censorship at this time.
Miller's greatest strength is probably his flexible, vigorously
colloquial dialogue. His political satire is mostly contained in
the poetry, which attacks Walpole's administration with increasing
vehemence through the seventeen-thirties, until its fall. In 1740
two poems that used Pope in symbolic contrast to Walpole caused a
sensation. In both poetry and plays Miller is also a social satirist,
who lays unusually strong emphasis on false taste and the deterioration
of culture
Election, Brotherhood and Inheritance: A Canonical Reading of the Esau and Edom Traditions
No full textWhat is the reader of the Bible to make of Esau, Jacob’s brother? Why is Israel’s neighbor Edom treated so harshly in the prophetic literature? And how might one understand the relationship of these traditions? This study engages these questions by offering a canonical reading of the Esau and Edom traditions of the Hebrew Bible in light of the theological issue of election, looking specifically at the portrayal of Esau and Edom in Genesis, Deuteronomy, and the prophetic material. First, it is argued that the depiction of Esau in Genesis is, on the whole, positive. Though the unchosen son, Esau is blessed and responds well to the challenges life presents him with. Thus, the unchosen brother is by no means cursed or excluded from the divine economy. These motifs find resonance in Deuteronomy, which in particular construes the issue of land possession in explicitly theological language, while reinforcing the kinship motif. Second, it is put forward that Edom is portrayed negatively by the prophets for violating a relationship of brotherhood, and for disrespecting the divine apportioning of the lands. It is this twofold rejection of their brother Israel as well as YHWH who has appointed the lands that helps account for the harsh message of the prophets. And third, it is suggested that these two traditions have resonance with one another based on their overarching theological concerns, heuristically labeled brotherhood and inheritance. Returning to the issue of election, it is proposed that these themes may helpfully be understood within the theological categories of divine initiative and human response, as the response of those involved is taken up in YHWH’s own responsiveness, whether in blessing or judgment
Philip Huntley Pope Correspondence
No full textEntries include typed letters, newspaper clippings with the photographic images of Louise Rich\u27s daughter Dinah as well as the famed author Louise Rich\u27s marriage to her second husband, and a descriptive newspaper article written by Mitchell and concerning Rich\u27s recordings for the blind
Chronicle (Paterson, NJ) Vol. 32, No.50, Dec. 11, 1960
No full textLocal information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements. This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952)
Contact of Cultures and the Image of Japan in European Fiction (Frigate “Pallada” by I. Goncharov and The Thousand Autumns of Jacob de Zoet by D. Mitchell)
No full textПоступила в редакцию: 21.01.2022. Принята к печати: 07.04.2022.Submitted: 21.01.2022. Accepted: 07.04.2022.В статье рассматривается ситуация контакта европейской и японской культур и образ Японии, созданный в классическом произведении русской литературы И. А. Гончарова «Фрегат Паллада» (1858) и в романе современного английского писателя Д. Митчелла «Тысяча осеней Якоба де Зута» (2010). Написанные в разное время, произведения повествуют об одном периоде и схожих событиях, обе книги имеют документальную историческую основу. Отдельное внимание уделяется героям-переводчикам, которые присутствуют в текстах двух произведений и выполняют важную роль при осуществлении межкультурного взаимодействия. Методология исследования включает в себя методы компаративного литературоведения, а также постулаты постколониальных исследований, в частности, идеи Э. Саида об ориентализме и этноцентризме. Сравнение и анализ текстов двух произведений показывает, что образ Японии, созданный двумя писателями, имеет ряд схожих черт, что подтверждает его объективный характер. С другой стороны, выраженная в текстах авторская точка зрения и взгляд на Японию отличаются кардинально. Для русского писателя это взгляд со стороны и сверху вниз, в японцах он отмечает «странность» и «детскость» как основные национальные черты. Гончаров стоит на позициях евроцентризма, что обусловлено рядом факторов: его знание Японии — внешнее, он государственный чиновник и заботится об интересах России, он представитель влиятельной группы отечественной интеллигенции. Знание Японии и ее культуры у Д. Митчелла глубокое и внутреннее в силу причин биографического характера. Английский писатель создает бикультурный роман, в котором европейский и японский мир одинаково значимы. Таким образом, в романе автор предлагает современную точку зрения на мироустройство и межкультурную коммуникацию.This article studies the situation of contact between European and Japanese cultures and the image of Japan created in the classical work of Russian literature Frigate “Pallada” (1858) by I. Goncharov and in the novel The Thousand Autumns of Jacob de Zoet (2010) by David Mitchell, a contemporary British writer. The books were written during different periods of time, but they describe the same historical period and similar events; they both have documentary foundation. Special attention is paid to translators as characters of the books who play an important role in the plot development and provide intercultural communication. The research methodology combines methods of comparative literary criticism with a post-colonial approach, E. Said’s ideas about orientalism and ethnocentrism in particular. Comparative analysis of the two books demonstrates that the image of Japan created by the two writers has a number of similar features, which confirms its objective nature. Conversely, the authors’ perspectives and points of view of Japan differ drastically. The Russian writer looks at the Japanese down and from the outside; he considers “strangeness” and “childishness” to be their national features. Goncharov’s Eurocentric position is explained by several reasons: his knowledge of Japan was external, he was a civil servant, who cared mostly about the interests of Russia, and he represented an influential group of Eurocentric intelligentsia. D. Mitchell’s knowledge of Japan and its culture is deep and internal due to his biography. The English writer creates a bicultural novel in which the European and the Japanese worlds are equally significant. Thus, in the novel, the author offers a modern point of view on the world order and intercultural communication
Market Liquidity as a Sentiment Indicator
No full textWe build a model that helps explain why increases in liquidity - such as lower bid-ask spreads, a lower price impact of trade, or higher share turnover - predict lower subsequent returns in both firm-level and aggregate data. The model features a class of irrational investors, who underreact to the information contained in order flow, thereby boosting liquidity. In the presence of short-sales constraints, unusually high liquidity is a symptom of the fact that the market is currently dominated by these irrational investors, and hence is overvalued. This theory can also explain how managers might successfully time the market for seasoned equity offerings (SEOs), by simply following a rule of thumb that involves issuing when the SEO market is particularly liquid. Empirically, we find that: i) aggregate measures of equity issuance and share turnover are highly correlated; yet ii) in a multiple regression, both have incremental predictive power for future equal-weighted market returns.
Aboveground Rather Than Belowground Productivity Drives Variability in Miscanthus × giganteus Net Primary Productivity
No full textQuantifying the carbon (C) uptake of Miscanthus × giganteus (M × g) in both aboveground and belowground structures (e.g., net primary productivity (NPP)) and differences among methodological approaches is crucial. Our objectives were to directly measure Mxg NPP and evaluate the effects of nitrogen application, location, and belowground biomass sampling methods. We hypothesize that increased nitrogen application increases the overall NPP of M × g and that quantifying rhizome biomass using excavations will produce the lowest variability between replicates. We collected biomass from mature M × g stands from three locations in Iowa with three nitrogen application rates and one site in Illinois. We destructively sampled at two time points, when rhizome mass is anticipated to be at a minimum (initial) and anticipated to be at its maximum (peak). Biomass was collected from 1 × 1 m quadrats in which one in-clump and one beside-clump cores were collected and then excavated to 30 cm depth to extract all rhizomes. We found that aboveground M × g NPP ranged from 15.4 Mg Da ha–1 year–1 to 36.4 Mg Da ha–1 year–1 and belowground M × g NPP ranged from 4.4 Mg Da ha–1 year–1 to 19.6 Mg Da ha–1 year–1. M × g NPP varied across sites, fertilization, and calculation assumptions. Aboveground NPP (yield) was on average 68.7% of the total NPP. Root-to-shoot ratios at peak biomass decreased with nitrogen application rate, from an average of 1.9 for 0 N plots to 0.89 for 224 N fertilized plots. There was more variation in core data than from excavations; however, when in-clump and beside-clump cores were averaged together, core and excavation averages were not different. Overall, these results show that the range of mature M × g NPP is driven by aboveground productivity, influenced by nitrogen application and site. Our results provide useful data to constrain agro-ecosystem models and provide crucial insights for future perennial belowground sampling.This article is published as Hartman, Theodore, Jacob E. Studt, Andy VanLoocke, Marshall D. McDaniel, Adina Howe, Michael D. Masters, Corey A. Mitchell, Evan H. DeLucia, and Emily A. Heaton. "Aboveground Rather Than Belowground Productivity Drives Variability in Miscanthus× giganteus Net Primary Productivity." GCB Bioenergy 17, no. 9 (2025): e70072. https://doi.org/10.1111/gcbb.70072This work was funded by the DOE Center for Advanced Bioenergy and Bioproducts Innovation (U.S. Department of Energy, Office of Science, Biological and Environmental Research Program under Award Number DE-SC0018420). Any opinions, findings, and conclusions or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the U.S. Department of Energy. This research is part of “#DiverseCornBelt (#DCB): Enhancing rural resilience through landscape diversity in the Midwest” and is supported by Agriculture and Food Research Initiative Competitive Grant no. 2021-68012-35896 from the USDA National Institute of Food and Agriculture. Project website: www.diversecornbelt.org
mcbooki438p342: Chapter Twenty-Eight, The L.D.S. Church in Milford, Bishops of the Milford Ward, L.D.S. Sunday School
No full textCHAPTER TWENTY-EIGHT THE L. D. S. CHURCH IN MILFORD The first services for the Latter-day Saints to be held in Milford were in the Ebenezer Tanner Sr. home on Main Street. Later, services were conducted in the old Palmer building, the school house, and other locations. The first L. D. S. Sunday School was organized July 17, 1892, with James C. Madsen, superintendent; Con E. Sawyer and Samuel Naylor, assistants. The first session was held a week later with ten officers and teachers and 73 enrolled. BISHOPS OF THE MILFORD WARD Ebenezer Tanner Sr. was the presiding elder, in the early days when Milford was a part of the Minersville Ward. On January 11, 1904, according to the Sunday School historical record, a meeting was held for the purpose of organizing the Milford Ward. The organization took place under the direction of Apostle Wilford Woodruff. Jacob T. Tanner was appointed bishop of the new ward, with William J. Burns and Thomas C. Reed as counselors, and Mr. Burns acting as ward clerk. Other bishops are given up to present date, in order of service: Ebenezer Tanner Jr., Oct. 5, 1906; William J. Burns, July 19, 1909; Edward H. Bird, August 17, 1920; William A. Miller, August 19, 1928; Edward H. Bird, April 27, 1936; Joy M. Christensen, May 17, 1937, Alvin Baker, April 30, 1939; Lawrence Peterson, September 15, 1940; Bert Waite, August 17, 1941; Carlyle F. Gronning, May 17, 1942; Ira Mitchell Fisher, August 26, 1945; George Carlos Goodwin, February 9, 1947. L. D. S. SUNDAY SCHOOL Sunday School has been held continuously since the first organization. The following men have held the posi
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