37 research outputs found
Antibacterial Activities and Molecular Docking of Novel Sulfone Biscompound Containing Bioactive 1,2,3-Triazole Moiety
No full textIn this study, a new synthetic 1,2,3-triazole-containing disulfone compound was derived from dapsone. Its chemical structure was confirmed using microchemical and analytical data, and it was tested for its in vitro antibacterial potential. Six different pathogenic bacteria were selected. MICs values and ATP levels were determined. Further, toxicity performance was measured using MicroTox Analyzer. In addition, a molecular docking study was performed against two vital enzymes: DNA gyrase and Dihydropteroate synthase. The results of antibacterial abilities showed that the studied synthetic compound had a strong bactericidal effect against all tested bacterial strains, as Gram-negative species were more susceptible to the compound than Gram-positive species. Toxicity results showed that the compound is biocompatible and safe without toxic impact. The molecular docking of the compound showed interactions within the pocket of two enzymes, which are able to stabilize the compound and reveal its antimicrobial activity. Hence, from these results, this study recommends that the established compound could be an outstanding candidate for fighting a broad spectrum of pathogenic bacterial strains, and it might therefore be used for biomedical and pharmaceutical applications
Bioremediation of oil-contaminated water by bacterial consortium immobilized on environment-friendly biocarriers
No full textThermosensitive chitosan/phosphate hydrogel-composites fortified with Ag versus Ag@Pd for biomedical applications
No full textPhenotyping using semi-automated BIOLOG and conventional PCR for identification of Bacillus isolated from biofilm of sink drainage pipes
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adhered to pipe surfaces in a model drinking water distribution system via various antibiofilm agents
No full textAssessment of the antimicrobial activity of the lipoidal and pigment extracts of Punica granatum L. leaves
No full textInnovative polymeric inorganic coagulant-flocculant for wastewater purification with simultaneous microbial reduction in treated effluent and sludge
No full textThe current work introduces polymeric inorganic coagulant-flocculants; poly-ferric chloride (POFC) which prepared using iron-containing waste. Different POFCs were produced according to Fe/basicity ratio. Likewise, the efficiency of POFC for purification and microbial decontamination of domestic wastewater was evaluated using various doses of POFC coagulant-flocculants. The solid content of the prepared POFCs was ranged from 11.1 to 29.9%, and density was varied from 1.13 to 1.24 kg/L with the varying iron/basicity ratios. Analyses results of XRD, FTIR and SEM confirm formation of a new inorganic polymeric ferric chloride that it is not assumed simple mixture of components. Moreover, the prepared POFCs showed coagulant-flocculant characteristics; therefore it is employed for treating wastewater without introducing organic polymer. Both POFCs coagulant-flocculants showed removal efficiencies of 99, 99 and 91% for total suspended solids (TSS), turbidity and chemical oxygen demand (COD) from domestic wastewater. Also, a complete deactivation of the tested waterborne species in wastewater was achieved at 100 ppm dose of POFCs. At POFC dose of 150 ppm, it was found that the anaerobic microbes and sulfate-reducing bacteria in sludge were reduced by 99.9 and 98%, respectively. The deactivation anaerobic micobes and sulfate-reducing bacteria in the produced sludge by using POFC will result in odor reduction generated from sludge. Moreover, the integration between POFC-based coagulation and rapid sand filtration (RSF) lowers POFC dose use and showed a good efficiency for domestic wastewater purification and microbial decontamination. Finally, POFC-based treatment aids in the decrease organic and bacterial load that results in reducing disinfection use and declining disinfection by-products levels. Moreover, POFC-based treatment/rapid sand filtration is considered a well-located cost-effective train for purification of domestic wastewater and microbial decontamination in treated effluent and sludge and which can be reused for safe agricultural purpose
Quantification of the Metabolic Activities of Natural Biofilm of Different Microenvironments
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