12,436 research outputs found
Moderate alcohol intake reduces risk of ischemic stroke in Korea : Author Response
No full textThe conclusion of the study by Lee et al.1 should be limited to about 60% of Koreans with normal acetaldehyde-metabolizing capacity from intact aldehyde dehydrogenase 2 (ALDH2). The nondrinker reference group appeared to be largely different from those of similar Western studies, potentially more prone to stroke, likely suggesting overestimation of beneficial effect by moderate alcohol intake.N
Response by Kim and Bae to Letter Regarding Article, "Magnetic Resonance Imaging Versus Computed Tomography Angiography Based Selection for Endovascular Therapy in Patients With Acute Ischemic Stroke
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Response by Park and Bae to Letter Regarding Article, “One-Year Outcomes After Minor Stroke or High-Risk Transient Ischemic Attack: Korean Multicenter Stroke Registry Analysis”
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WSO895703 Supplemental material - Supplemental material for Hematoma Hounsfield units and expansion of intracerebral hemorrhage: A potential marker of hemostatic clot contraction
No full textSupplemental material, WSO895703 Supplemental material for Hematoma Hounsfield units and expansion of intracerebral hemorrhage: A potential marker of hemostatic clot contraction by Han-Gil Jeong, Jae Seung Bang, Beom Joon Kim, Hee-Joon Bae and Moon-Ku Han in International Journal of Stroke</p
Response by Lee et al to Letter Regarding Article, “Predictive Value of Pulse Pressure in Acute Ischemic Stroke for Future Major Vascular Events”
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What have clinical trials taught us about brain health?
No full textThe Global Burden of Disease Study projects an almost tripling of dementia cases worldwide in the next 30 years making it important to recognize and understand modifiable risks and preventatives for cognitive impairment. Recent studies suggest that prevention or treatment of cardiovascular risks may be an important strategy to prevent or slow the progression of cognitive impairment. In 2017, the American Heart Association and American Stroke Association introduced metrics for ''optimal brain health''. These metrics defined brain health in terms of ideal health behaviors and factors.Since then and leading up to 2017, a number of clinical trials have been conducted to investigate the potential of modification of cardiovascular risks on prevention of dementia or cognitive impairment and thus, enhancement of brain health. This discussion is a review of findings from clinical trials focusing on interventions, including antihypertensive agents, glycemic control and lipid-lowering therapies, multidomain approaches, and antithrombotic medications. Notably, the results highlight the promise of intensive blood pressure lowering strategies and multidomain approaches, as evidenced by the FINGER trial. The review also discusses the potential of treatment or prevention of cerebral small vessel disease (cSVD) and the application of Mendelian randomization as a strategy to preserve brain structure and function
Spontaneous Intracerebral Hemorrhage: Management
No full textSpontaneous non-traumatic intracerebral hemorrhage (ICH) remains a significant cause of mortality and morbidity throughout the world. To improve the devastating course of ICH, various clinical trials for medical and surgical interventions have been conducted in the last 10 years. Recent large-scale clinical trials have reported that early intensive blood pressure reduction can be a safe and feasible strategy for ICH, and have suggested a safe target range for systolic blood pressure. While new medical therapies associated with warfarin and non-vitamin K antagonist oral anticoagulants have been developed to treat ICH, recent trials have not been able to demonstrate the overall beneficial effects of surgical intervention on mortality and functional outcomes. However, some patients with ICH may benefit from surgical management in specific clinical contexts and/or at specific times. Furthermore, clinical trials for minimally invasive surgical evacuation methods are ongoing and may provide positive evidence. Upon understanding the current guidelines for the management of ICH, clinicians can administer appropriate treatment and attempt to improve the clinical outcome of ICH. The purpose of this review is to help in the decision-making of the medical and surgical management of ICH.Y
Treatment of vascular dementia: Evidence from epidemiologic studies
No full textThis article discusses the most relevant recent evidence on the prevention and treatment of vascular dementia from epidemiologic studies. Vascular dementia is the most common form of dementia after Alzheimer's disease and remains the only one that is preventable, although most of our knowledge about primary and secondary prevention of vascular dementia comes from direct extrapolation from works in stroke. Furthermore, at present there are no approved therapeutic agents for the treatment of vascular dementia. Recently, however, a number of reasonable studies on vascular dementia have been available. It is clear that rigorous control of vascular risk factors is important in primary and secondary prevention of vascular dementia, and perhaps in ameliorating its mild form. A rational therapeutic approach to the treatment of vascular dementia should be based on an understanding of its broad clinical spectrum and the diverse causes that may be responsive to currently available treatments. Copyright © 2005 by Current Science Inc.N
Response by Tanaka et al to Letter Regarding Article, "atrial Fibrillation-Associated Ischemic Stroke Patients with Prior Anticoagulation Have Higher Risk for Recurrent Stroke"
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