16,311 research outputs found
Microlithosia laosana Bayarsaikhan & Lee & Bae 2018, n. sp.
No full textMicrolithosia laosana Bayarsaikhan & Bae, n. sp. Distribution. Laos (Ban Tha).Published as part of Bayarsaikhan, Ulziijargal, Lee, Dong-June & Bae, Yang-Seop, 2018, Genus Microlithosia (Lepidoptera, Erebidae, Arctiinae) in Laos, with the description of a new species, pp. 502-508 in Zootaxa 4420 (4) on page 508, DOI: 10.11646/zootaxa.4420.4.3, http://zenodo.org/record/145540
In vivo application of base and prime editing to treat inherited retinal diseases
No full textInherited retinal diseases (IRDs) are vision-threatening retinal disorders caused by pathogenic variants of genes related to visual functions. Genomic analyses in patients with IRDs have revealed pathogenic variants which affect vision. However, treatment options for IRDs are limited to nutritional supplements regardless of genetic variants or gene-targeting approaches based on antisense oligonucleotides and adeno-associated virus vectors limited to targeting few genes. Genome editing, particularly that involving clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 technologies, can correct pathogenic variants and provide additional treatment opportunities. Recently developed base and prime editing platforms based on CRISPR-Cas9 technologies are promising for therapeutic genome editing because they do not employ double-stranded breaks (DSBs), which are associated with P53 activation, large deletions, and chromosomal translocations. Instead, using attached deaminases and reverse transcriptases, base and prime editing efficiently induces specific base substitutions and intended genetic changes (substitutions, deletions, or insertions), respectively, without DSBs. In this review, we will discuss the recent in vivo application of CRISPR-Cas9 technologies, focusing on base and prime editing, in animal models of IRDs.N
Supplemental Material, Supp - Dual Effects of Human Placenta-Derived Neural Cells on Neuroprotection and the Inhibition of Neuroinflammation in a Rodent Model of Parkinson’s Disease
No full textSupplemental Material, Supp for Dual Effects of Human Placenta-Derived Neural Cells on Neuroprotection and the Inhibition of Neuroinflammation in a Rodent Model of Parkinson’s Disease by Han Wool Kim, Hyun-Seob Lee, Jun Mo Kang, Sang-Hun Bae, Chul Kim, Sang-Hun Lee, Johannes Schwarz, Gi Jin Kim, Jin-Su Kim, Dong Hyun Cha, Joopyung Kim, Sung Woon Chang, Tae Hee Lee, and Jisook Moon in Cell Transplantation</p
UML-based Modeling and Simulation Method for Mission-Critical Real-Time Embedded System Development
No full textZhi hun he zai shuang ceng mo zhong de fen zi dong li xue mo ni
No full textHong, Chun Kit = 脂混合在雙層膜中的分子動力學模擬 / 洪俊傑.Thesis M.Phil. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 59-66).Abstracts also in Chinese.Title from PDF title page (viewed on 16, November, 2016).Hong, Chun Kit = Zhi hun he zai shuang ceng mo zhong de fen zi dong li xue mo ni / Hong Junjie
Genus Microlithosia (Lepidoptera, Erebidae, Arctiinae) in Laos, with the description of a new species
No full textBayarsaikhan, Ulziijargal, Lee, Dong-June, Bae, Yang-Seop (2018): Genus Microlithosia (Lepidoptera, Erebidae, Arctiinae) in Laos, with the description of a new species. Zootaxa 4420 (4): 502-508, DOI: 10.11646/zootaxa.4420.4.
sj-docx-1-wso-10.1177_17474930231158211 – Supplemental material for Optimal use of antithrombotic agents in ischemic stroke with atrial fibrillation and large artery atherosclerosis
No full textSupplemental material, sj-docx-1-wso-10.1177_17474930231158211 for Optimal use of antithrombotic agents in ischemic stroke with atrial fibrillation and large artery atherosclerosis by Tae Jung Kim, Ji Sung Lee, Jae Sun Yoon, Mi Sun Oh, Ji-Woo Kim, Soo-Hyun Park, Keun-Hwa Jung, Hyun Young Kim, Jee-Hyun Kwon, Hye-Yeon Choi, Hahn Young Kim, Kyung Yoon Eah, Sang Won Han, Hyung-Geun Oh, Young-Jae Kim, Byoung-Soo Shin, Chang Hun Kim, Chi Kyung Kim, Jong-Moo Park, Kyung Bok Lee, Tai Hwan Park, Jun Lee, Man-Seok Park, Jay Chol Choi, Chulho Kim, Dong-Ick Shin, Soo Joo Lee, Dong-Eog Kim, Jae-Kwan Cha, Eung-Gyu Kim, Kyung-Ho Yu, Keun-Sik Hong, Young-Seok Lee, Ju-Hun Lee, Sung Il Sohn, Hee-Joon Bae, Young-Bae Lee, Jun Hong Lee, Joung-Ho Rha, Byung-Chul Lee, Dae-Il Chang, Sang-Bae Ko and Byung-Woo Yoon in International Journal of Stroke</p
Visual function restoration in a mouse model of Leber congenital amaurosis via therapeutic base editing
No full textLeber congenital amaurosis (LCA), an inherited retinal degeneration, causes severe visual dysfunction in children and adolescents. In patients with LCA, pathogenic variants, such as RPE65, are evident in specific genes, related to the functions of retinal pigment epithelium and photoreceptors. In contrast to the original Cas9, base editing tools can correct pathogenic substitutions without generation of DNA double-stranded breaks (DSBs). In this study, dual adeno-associated virus (AAV) vectors containing split adenine base editors (ABEs) with trans-splicing intein were prepared for in vivo base editing in retinal degeneration of 12 (rd12) mice, an animal model of LCA, possessing a nonsense mutation of C to T transition in the Rpe65 gene (p.R44X). Subretinal injection of AAV-ABE in retinal pigment epithelial cells of rd12 mice resulted in an A to G transition. The on-target editing was sufficient for recovery of wild-type mRNA, RPE65 protein, and light-induced electrical responses from the retina. Compared with our previous therapeutic editing strategies using Cas9 and prime editing, or with the gene transfer strategy shown in the current study, our results suggest that, considering the editing efficacy and functional recovery, ABEs could be a strong, reliable method for correction of pathogenic variants in the treatment of LCA
Chao leng xuan liang hun he wu zhong de yi he jian xiang gan zi xuan dong li xue
No full textLi, Xiaoke = 超冷旋量混合物中的異核間相干自旋動力學 / 李小科.Thesis Ph.D. Chinese University of Hong Kong 2015.Includes bibliographical references (leaves 126-142).Abstracts also in Chinese.Title from PDF title page (viewed on 25, October, 2016).Li, Xiaoke = Chao leng xuan liang hun he wu zhong de yi he jian xiang gan zi xuan dong li xue / Li Xiaoke
Diduga kohkongensis Bayarsaikhan & Lee & Bae 2018, n. sp.
No full text<i>Diduga kohkongensis</i> Bayarsaikhan & Bae, n. sp. <p>(Figs. 3, 10, 21)</p> <p> <b>Type materials. Holotype:</b> 1 ♂, Samkos, Koh Kong Prov. (N12˚12′48.1″, E102˚54′12.5″, Alt.: 830m), 6. II.2015 (YS Bae, YD Ju, BS Park, SM Na, JW Kim, DJ Lee), Gen. Slide No. INU˗1412C. <b>Paratype:</b> 1 ♀, Samkos, Koh Kong Prov. (N12˚12′48.1″, E102˚54′12.5″, Alt.: 830m), 6. II.2015 (YS Bae, YD Ju, BS Park, SM Na, JW Kim, DJ Lee), Gen. Slide No. INU˗1743C.</p> <p> <b>Diagnosis.</b> By the wing pattern, the new species is similar to <i>Diduga flavicostata</i> (Snellen, 1879) (Bucsek 2012: 25, pl. 4: 52, gen. Mal191), but the male genitalia structure of both species are significantly different: uncus irregularly conic, with strongly hook˗shaped apical process; valva narrowly rectangular, with a spine˗shaped and a membranous, rounded projections in apex; a harpe present; aedeagus with a row of six irregularly triangular cornuti (Fig. 10). In <i>D. flavicostata</i>, uncus weakly broad in medially, with weakly waved apex; valva broadly rectangular, with irregularly angled apex; a harpe absent; aedeagus with two slender spine˗shaped cornuti (Bucsek 2012: gen. fig. Mal191).</p> <p> <b>Description.</b> <i>Adult</i> (Figs. 3a, 3b). Length of forewing 4˗5 mm in male and female. Head, patagium and tegula deep yellow. Thorax dark brown. Forewing ground color dark brown (dark brown part looks triangular), with deep yellow margin from basal to tornus, which hind border of margin broadly dentate; with several small, dark brown dots in apical half of costal margin; cilia deep yellow. Hindwing ground color fuscous; cilia fuscous. Abdomen brown, with deep yellow tuft.</p> <p> <i>Male genitalia</i> (Fig. 10). Uncus irregularly conic, with hook˗shaped apical process. Tegumen triangular, weakly sclerotized. Valva symmetric, stout, with a large, tapering spine˗shaped and a membranous, rounded projections in apex of valva; a basal harpe large, consisting of stout spines. Juxta trapezoid, weakly sclerotized. Saccus broadly “U”˗shaped. Aedeagus stout, weakly sclerotized and vesica with a row of six irregularly triangular cornuti and scobination.</p> <p> <i>Female genitalia</i> (Fig. 21). Papillae anales weakly covered with setae. Ductus bursae stout, tubular, weakly sclerotized whole of length, with a strongly sclerotized band˗shaped plate in cervix of bursae. Corpus bursae rectangular, membranous, with plate of small spines.</p> <p> <b>Distribution.</b> Cambodia (Koh Kong province).</p> <p> <b>Etymology.</b> The species is named after the type locality province, Koh Kong Province, Cambodia.</p>Published as part of <i>Bayarsaikhan, Ulziijargal, Lee, Dong ˗ June & Bae, Yang ˗ Seop, 2018, Three new species of Diduga Moore, [1887] (Lepidoptera, Erebidae, Arctiinae) from Cambodia, pp. 411-424 in Zootaxa 4514 (3)</i> on pages 416-417, DOI: 10.11646/zootaxa.4514.3.6, <a href="http://zenodo.org/record/2608133">http://zenodo.org/record/2608133</a>
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