176,502 research outputs found
Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1? in chondrocyte/agarose constructs
No full textIntroduction: The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression. Methods: Constructs were cultured under free-swelling conditions or subjected to dynamic compression with low (0.1 to 100 pM) or high concentrations (1 to 1,000 nM) of CNP, interleukin-1? (IL-1?), and/or KT-5823 (inhibits cyclic GMP-dependent protein kinase II (PKGII)). Anabolic and catabolic activities were assessed as follows: nitric oxide (NO) and prostaglandin E2 (PGE2) release, and [3H]-thymidine and 35SO4 incorporation were quantified by using biochemical assays. Gene expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), aggrecan, and collagen type II were assessed with real-time quantitative PCR (qPCR). Two-way ANOVA and the post hoc Bonferroni-corrected t tests were used to examine data. Results: CNP reduced NO and PGE2 release and partially restored [3H]-thymidine and 35SO4 incorporation in constructs cultured with IL-1?. The response was dependent on the concentration of CNP, such that 100 pM increased [3H]-thymidine incorporation (P < 0.001). This is in contrast to 35SO4 incorporation, which was enhanced with 100 or 1000 nM CNP in the presence and absence of IL-1? (P < 0.001). Stimulation by both dynamic compression and CNP and/or the PKGII inhibitor further reduced NO and PGE2 release and restored [3H]-thymidine and 35SO4 incorporation. In the presence and absence of IL-1?, the magnitude of stimulation for [3H]-thymidine and 35SO4 incorporation by dynamic compression was dependent on the concentration of CNP and the response was inhibited with the PKGII inhibitor. In addition, stimulation by CNP and/or dynamic compression reduced IL-1?-induced iNOS and COX-2 expression and restored aggrecan and collagen type II expression. The catabolic response was not further influenced with the PKGII inhibitor in IL-1?-treated constructs. Conclusions: Treatment with CNP and dynamic compression increased anabolic activities and blocked catabolic effects induced by IL-1?. The anabolic response was PKGII mediated and raises important questions about the molecular mechanisms of CNP with mechanical signals in cartilage. Therapeutic agents like CNP could be administered in conjunction with controlled exercise therapy to slow the OA disease progression and to repair damaged cartilage. The findings from this research provide the potential for developing novel agents to slow the pathophysiologic mechanisms and to treat OA in the young and old. <br/
La valsorine : valse brillante pour piano / par C. Bader ; [ill. par] Bertrand
No full textTitre uniforme : Bader, René (18..-19.. ; compositeur). Compositeur. [La valsorine. Piano]Valses (piano) -- +* 1800......- 1899......+:19e siècle:Piano, Musique de -- +* 1800......- 1899......+:19e siècle
Some remarks on flocks
No full textNew proofs are given of the fundamental results of Bader,
Lunardon and Thas relating flocks of the quadratic
cone in pg(3,q), q odd, and BLT-sets of Q(4,q). We also
show that there is a unique BLT-set of H(3,9). The model of
Penttila for Q(4,q) q odd, is extended to
Q(2m,q) to construct partial flocks of size qm/2+m/2-1 of the
cone K in pg(2m-1,q) with vertex a point and base
Q(2m-2,q) , where q is congruent to 1 or 3 modulo 8 and m
is even. These
partial flocks are larger than the largest previously known
for m>2 . Also, the
example of O'Keefe and Thas of a partial
flock of K in pg(5,3) of size 6 is generalised to a
partial flock of the cone K of pg(2pn-1,p) of size 2pn , for any prime p congruent to 1 or 3 modulo 8,
with the corresponding partial BLT-set of
Q(2pn,p) admitting the symmetric group of degree 2pn+1
Brachychthonius gygeri Bader, 1963, sp. n.
No full text<p>Brachychthonius gygeri sp. n.</p> <p>Körpergrösse 155 x 72 µ. Propodosoma 52 µ, Hysterosoma 103 µ. Rostralhaare 16 µ, Körperhaare 12 µ. Pseudostigmatische Organe 36 µ.</p> <p>Die neue Art steht Brachychthonius berlesei Willmann, 1928 sehr nahe, vor allem in bezug auf die Körpergestalt. Sie unterscheidet sich aber von ihr durch kleinere Körper- und durch die längeren Pseudostigmatischen Organe, deren distale Hälfte zwar ebenfalls ährenartig gestaltet ist, doch aber deutlich mit grannenartigen Borsten besetzt ist, und die in eine scharfe Spitze ausläuft.</p> <p>Die Körperfarbe ist hell-strohgelb, das Hysterosoma ist gut geschultert, die Rücken- sind einfach gestaltet. Die Ornamentierung der Rückendecke des Hysterosomas ist nur durch schwache, nicht in sich geschlossene Rillen erkennbar, während auf dem Propodosoma deutliche Chitinleisten vorhanden sind, welche wallartig den äusseren Rand desselben verstärken. In ihrem Innenfeld ist eine schwach ornamentierte Fläche, die bis zu den Pseudostigmatischen Organen reicht. Die Tarsen der Beine sind mit einer einzigen, sichelförmigen, relativ grossen Kralle besetzt.</p> <p>Im Innern des Hysterosomas sind drei eierartige, durch dunklere Ausfärbung leicht erkennbare Gebilde vorhanden, von denen aber nur eines sich durch deutliche Umrisse auszeichnet und als Ei betrachtet werden darf, während die beiden anderen wahrscheinlich nur als Kotballen zu bewerten sind.</p> <p>Fundort: Basel, Botanischer Garten (Funddatum unbekannt).</p> <p>Alle Arten der Gattung Brachychthonius sind bekannt als Bewohner von Moor- und Rohhumus-Böden und von Moospolstern trockener bis nasser Standorte. Sie kommen als Parasiten der Japygiden-Zuchten nicht in Betracht, das Auftreten eines einzelnen Tieres ist nur als zufällig zu betrachten. Die Tiere ernähren sich sehr wahrscheinlich von Abbaustoffen pflanzlichen und tierischen Ursprungs.</p> <p>Das Typus-Präparat von Brachychthonius gygeri Schweizer, 1963 wird als Holotypus Nr. N P 2190 im Naturhistorischen Museum aufbewahrt.</p>Published as part of <i>Bader, C., 1963, Eine Milbendiagnose aus dem Nachlass Dr. Josef Schweizer, pp. 67-68 in Verhandlungen der Naturforschenden Gesellschaft in Basel 74</i> on pages 67-6
Professor Dan L Bader, scientist, mentor, and friend
No full textThis special edition of the Journal of Tissue Viability provides a collection of scientific excellence led by the late Professor Dan L Bader. These papers form part of an academic career spanning over 40 years, working in collaboration with partners from around the world to provide novel insights into factors effecting tissue viability and technologies to promote wound prevention. Dan's great ambition was to translate his work from ‘bench to bedside’, using the highest quality experimental data [[1], [2], [3], [4], [5], [6], [7], [8]], computational modelling [9,10] and clinical studies [11,12] to create a step change in our understanding of factors which effect tissue health. This body of work originated from his career spanning several academic institutions including Queen Mary University London (QMUL), Technical University Eindhoven (TUE), and the University of Southampton (UoS).No Full Tex
Harry Bernhardt, Military and Firemen's Parade
No full textThis photograph captures the beginning of the Military and Firemen's parade on July 11, 1955. Harry Bernhardt, center, served as the chairman of Egg Harbor City's Special Events Committee. Adolph Bader, assistant chairman and marshall, and Albert Sorg also marched in the parade, costumed as Native Americans.
The color guard marched behind Bernhardt, Bader, and Sorg. Governor Robert B. Mayner, Mayor W. Haines Maxwell, and J. William Weisbecker rode in the car behind the color guard.
This image appeared on the front page of the July 14, 1955 edition of The News of Egg Harbor City.
Left to right: Adolph Bader, Harry Bernhardt, Albert C. Sor
Military and Firemen Parade Approaching, Egg Harbor City Centennial
No full textPart of the Egg Harbor City Centennial Celebration, this image shows the lead marchers of the Military and Firemen parade, namely Harry Bernhardt, Adolph Bader, and Albert C. Sorg.
Although Bernhardt is the central person in this image, the crowds lining the street are of the most interest. There is standing room only on the sidewalk, left. A slightly smaller crowd sits in chairs or on the curb near the auto shop, far right.
An article in the July 14, 1955 edition of "The News" notes that more than 10,000 people witnessed the Military and Firemen parade.
Left to right: Adolph Bader, Harry Bernhardt, Albert C. Sor
C. J. Ruijgh, Études sur la grammaire et le vocabulaire du grec mycénien, 1967
No full textBader Françoise. C. J. Ruijgh, Études sur la grammaire et le vocabulaire du grec mycénien, 1967. In: Revue des Études Anciennes. Tome 69, 1967, n°3-4. pp. 366-368
Numerical analysis of ischemia- and compression-induced injury in tissue-engineered skeletal muscle constructs
No full textPressure-related deep tissue injury may develop in skeletal muscle tissue which is subjected to prolonged compression. For early detection, it is important to understand the underlying damage processes. Gawlitta et al. [Gawlitta, D., C. W. J. Oomens, D. L. Bader, F. P. T. Baaijens, and C. V. C. Bouten. Temporal differences in the influence of ischemic factors and deformation on the metabolism of engineered skeletal muscle. J. Appl. Physiol. 103(2):464–473, 2007b] subjected tissue-engineered muscle constructs to ischemia and deformation to study their effects on viability. Contrary to previous findings, no decrease in viability was found due to compression. However, the nature of their measurement method complicated interpretation of the results, particularly when deformation was involved. Changes in the constructs were assessed by measurements in the surrounding medium. The theoretical model developed in the present study describes metabolism, diffusion, and cell death in the experiments, and accounts for reduced diffusion due to compression. It was demonstrated that the lack of effect of compression on tissue viability, as measured in the experiments, could be explained by the compression-induced decrease in diffusivity. Compression did lead to considerable cell death but this could not be measured by Gawlitta et al. [Gawlitta, D., C. W. J. Oomens, D. L. Bader, F. P. T. Baaijens, and C. V. C. Bouten. Temporal differences in the influence of ischemic factors and deformation on the metabolism of engineered skeletal muscle. J. Appl. Physiol. 103(2):464–473, 2007b] because diffusion of the cell death marker to the medium was limited. This study shows that a proper description of transport processes is essential for a correct interpretation of experiments in which indirect measurement methods are used
- …
