171 research outputs found
Clinical Utility of Azacitidine in the Management of Acute Myeloid Leukemia: Update on Patient Selection and Reported Outcomes
No full textYenny Moreno Vanegas, Talha Badar Division of Hematology-Oncology and Blood and Marrow Transplantation and Cellular Therapy Program, Mayo Clinic, Jacksonville, FL, USACorrespondence: Talha Badar, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA, Email [email protected]: Acute myeloid leukemia (AML) is predominantly a disease of the elderly, and a significant proportion of these patients are not candidates for intensive, curative-intent therapies. Epigenetic dysregulation resulting in abnormal DNA hypermethylation is one of the hallmarks of AML pathogenesis. For the past two decades, hypomethylating agents including azacitidine (AZA) have been the mainstay of treatment for AML patients who are ineligible to receive intensive chemotherapies. As our understanding of AML disease biology has improved, several novel treatment combinations have been developed to improve the outcome of AML patients, with remarkable success. A considerable proportion of these novel combinations have utilized AZA as the backbone of their treatment scheme. In this review, we have highlighted the evolution of AML treatment, focusing on novel AZA-based treatment combinations and their clinical efficacy.Keywords: azacitidine, elderly AML, hypomethylating agent, azacitidine plus venetocla
A talha da igreja de Jesus de Aveiro 1
No full textCommented reading to the space of the church of Jesus as a heavenly metaphor and its
impact on the believer, in particular the Aveirenses who frequented it. In this context, it is intended to understand the aesthetic, formal and morphological evolution of the carving and gilded work of the Church of Jesus as a space integrated in the National Baroque [Churches lined with gold]. Starting from the concept of "Church Lined with Gold" we will pay homage to a researcher and author of the unique work "The Talha in Portugal", published in 1962 (54 years ago), Professor Robert Smith, which goes on to quote: Baroque tendency to harmonious unity, the carving of the altarpiece grandly invades the parietal surface of the chapel, constituting a "golden cave", and hence the rest of the interior, making it a whole church of gold
. Thus, based on the historical and documentary, visual and interpretative reading of the carving of the Church of Jesus of Aveiro, we will evaluate the compromise, as syntheses, between the archite ctural sobriety of the building and the exuberance of
the interior of the Church of Jesus, materializing in a visible way the Invisible - invisibilia per visibiliaLeitura comentada ao espaço da igreja de Jesus como metáfora celeste e o seu impacto no crente, em particular os aveirenses que a frequentavam.
Neste contexto, pretende - se entender a evolução estética, formal e morfológica da talha da Igreja de Jesus como espaço integrado no Barroco Nacional [Igrejas forradas de ouro]. Partindo assim, do conceito de “Igreja Forrada a Ouro” faremos a singela homenagem a um investigador e autor da obra singular “A Talha em Portugal”, publicada
em 1962 (h á 54 anos), o Professor Robert Smith , que se passa a citar: “segundo a tendência barroca à harmoniosa unidade, a talha do retábulo grandiosamente invade a superfície parietal da capela, constituindo uma “caverna dourada”, e daí o resto do interior, tornando - o uma igreja (toda de ouro) (Smith, 1962 p: 89).
Da leitura histórica e documental, visual e interpretativa da talha da Igreja de Jesus de Aveiro faremos, como síntese, a avalição acerca do compromisso existente entre a
sobriedade arquitetônica do edifício e a exuberância do interior da Igreja de Jesus materializando -se de forma visível o invisível – invisibilia per visibili
Turbulent structures in unsteady wall-bounded flow subject to temporal acceleration
No full textDirect numerical simulations (DNS) of a transient turbulent channel flow subject to constant temporal acceleration have been performed with a final Reynolds number of \Retau=800. The response of turbulent structures to the temporal acceleration is investigated. A significant delay in the response of turbulent flow is observed in various turbulent properties. It is found that the response of turbulent flow to temporal acceleration consists of two stages: the destruction of the initial \emph{old} turbulence, followed by the generation of \emph{new} turbulence associated with a higher number. The \emph{new} turbulence is much stronger than the \emph{old} turbulence
Sustainability In Engineering And Engineering Education: A Comparative Study Of German And Saudi Arabian Industries
No full textSustainability has become a major concern in the fields of engineering and engineering education. Organizations such as UNESCO have defined goals for sustainable development in engineering. As engineers design, develop, and implement products and processes that impact the environment and society, their role in promoting sustainable development is vital. Addressing sustainability in engineering curriculum is needed to equip engineers with the knowledge, skills, and attitudes required to develop sustainable solutions in their respective areas, and it involves merging the teaching of technical skills with a systems-based approach that considers the broader environmental and economical context of engineering. This 1 Corresponding Author Talha Bin Asad [email protected] requires collaboration between different disciplines and stakeholders, including engineers, educators, policymakers, and industry. This study investigates the industry practices regarding sustainability goals and measures in two countries. Another point of inquiry is to find practical recommendations from engineers and project managers to inform engineering education curriculum in terms of knowledge and awareness of sustainability. Qualitative case study protocol was followed in this research, and participants from Germany and Saudi Arabia were interviewed online. Thematic coding was performed to extract meaning making descriptions from the interview transcripts. In response to the interview prompts, the participants shared their perspectives of sustainability in their area of engineering. Their recommendations towards the curriculum development included making UN sustainability goals a part of engineering curriculum, while still teaching students to adopt a ‘lean product development approach’ in their course projects, so that they learn the practical implementation of sustainability in engineering projects as well as in life
Role of Allogeneic Hematopoietic Stem Cell Transplantation for Philadelphia Chromosome-Positive B-Cell Acute Lymphoblastic Leukemia in the Contemporary Era
No full textThe treatment of Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia (Ph+ B-cell ALL) has seen substantial progress over the past two decades. The introduction of BCR::ABL1 tyrosine kinase inhibitor (TKIs) has resulted in dramatic improvements in long-term survival. Allogeneic hematopoietic stem cell transplantation (allo-HSCT), with its curative potential, has always been an integral part of the treatment algorithm of Ph+ ALL. Recently, the approval of novel therapies such as blinatumomab, inotuzumab ozogamicin and chimeric antigen receptor T-cell (CAR-T) therapy in relapse and refractory (R/R) ALL have further improved outcomes of B-cell ALL. With potent TKIs and novel targeted therapy, the treatment guidelines for Ph+ ALL are evolving rapidly. Additionally, with improved tools for detecting measurable residual disease (MRD), there has been recent interest in redefining the role of allo-HSCT for some patients. In this context, we discuss the current evidence for the utilization of allo-HSCT for Ph+ ALL, focusing on novel therapies and MRD-directed care
Identifying lake longer-term dynamics via fuzzy relations and non-linear Kalman filters
No full textDimirovski, Georgi M. (Dogus Author) -- Dinibütün, Abdurrahman Talha (Dogus Author) -- Conference full title: 1999 European Control Conference, ECC 1999; Karlsruhe; Germany; 31 August 1999 through 3 September 1999A novel simulation modelling technique that may be used to reconstruct or predict longer-term water level dynamics of lakes and reservoirs has been elaborated. On the grounds of the conservation law and a kind of self-regulation property of these lakes, by using Kalman filters for the unmeasurable part of hydrologic-cycle dynamical path and output observation equation in traditional and in fuzzy-relational a simulation modelling technique was developed that is believed to have wide applicability. It has been applied to reconstruct successfully the behaviour of Ohridean and Prespanean Lakes during various time periods, despite the available records are interrupted, uncertain and unreliable due to historical circumstances
Knowledge and technology transfer: Novel results while teaching advanced courses
No full textDimirovski, Georgi M. (Dogus Author) -- Dinibütün, Abdurrahman Talha (Dogus Author)Graduate studies in fields of Engineering typically include advanced control theory. in turn, these courses enhance both academic and applied research, hence contributing to combined knowledge and technology transfer, in particular if supported by industry as well. This paper reports on such fruitful experiences at our universities through the math-analytical back-stepping and state-feedback control design methodologies. Computer simulation and laboratory experiments have demonstrated these controller designs possess quality performances, which are comparable with the other designs for the same applications.16th Triennial World Congress of International, Federation of Automatic Control, IFAC 2005, Location: , Czech Republic
Metal–organic framework based non-precious metal electrocatalysts for the oxygen reduction reaction
No full textProton-exchange membrane fuel cells (PEMFCs) are devices capable of converting the chemical energy stored in hydrogen into electrical energy for several applications. Their high energy conversion efficiency and environmentally friendly emissions have designated them as viable candidates to replace fossil fuel-based technologies, particularly in transportation applications. However, the high cost associated with the platinum-based catalyst required to drive the sluggish kinetics of the cathodic oxygen reduction reaction (ORR) have rendered these devices impractical on a large scale. To address this, the development of non-platinum group metal (non-PGM) catalysts is a research area of great relevance.
This thesis serves to (1) address the mechanism surrounding non-PGM electrocatalysts and provide a method to understand the structure-property relationship, and (2) study strategies in the synthesis of non-PGM electrocatalyst for greater homogeneity in the as-made active structures.
The first part of this thesis work involves the use of the zeolitic imidazolate framework ZIF-8 as a model precursor to understanding the role of temperature on the conversion of metal organic frameworks (MOFs) to an active catalyst. The experimental data together with the DFT calculations suggests that the proximity of carbon-encapsulated neighboring iron structures can play a role in activating surface carbon atoms leading to the cleavage of the OOH bond, a key step in the ORR.
In the second part of this thesis, the use of cadmium as a sacrificial metal instead of the widely-used zinc is presented. The use of cadmium allows for the synthesis of an active non-PGM electrocatalyst at a lower pyrolysis temperature, resulting in an abundance of single atom sites. Furthermore, at a higher pyrolysis temperature, the catalyst synthesized with cadmium as the sacrificial metal exhibited noteworthy activity in both a three-electrode half-cell test and a membrane electrode assembly (MEA) study.
Lastly, a MOF immobilization strategy is introduced which involved the use of Ketjen black carbon as a support to effectively anchor the MOF precursors prior to thermal treatment. This would allow for a greater dispersion of the single atom metal sites and curb sintering during thermal treatment. It was demonstrated that there was an exclusive formation of single atom iron structures after the pyrolysis using this strategy.
The work in this thesis provides the basis for a fresh outlook on the current work in the area of non-PGM electrocatalysts for the cathodic ORR. Through this work, we seek to expand on the understanding of these catalyst materials on a fundamental level and to propose strategies to design and develop highly active catalysts.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-05-01The student, Talha Al-Zoubi, accepted the attached license on 2021-03-28 at 19:46.The student, Talha Al-Zoubi, submitted this Dissertation for approval on 2021-03-28 at 19:57.This Dissertation was approved for publication on 2021-04-08 at 07:44.DSpace SAF Submission Ingestion Package generated from Vireo submission #16217 on 2021-09-16 at 20:07:53Made available in DSpace on 2021-09-17T04:04:05Z (GMT). No. of bitstreams: 2
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Upfront Immunotherapy Approaches in the Management of Adults with Acute Lymphoblastic Leukemia
No full textThe therapeutic landscape of adults with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is undergoing a paradigm shift, driven by the development of immunotherapy-based “chemo-free” and “chemo-light’ regimens. These strategies aim to achieve high efficacy with reduced toxicity, particularly in older adults who may not tolerate intensive chemotherapy. In Philadelphia chromosome-positive (Ph+) BCP-ALL, the incorporation of ABL tyrosine kinase inhibitors (TKIs) with blinatumomab (CD3/CD19 bispecific T-cell engager) has shown remarkable efficacy, with some studies reporting molecular response rates in the range of 90–100% and long-term survival exceeding 80% without the need for intensive chemotherapy or allogeneic hematopoietic cell transplantation (allo-HCT). In Philadelphia-negative (Ph−) BCP- ALL, an immunotherapy-based combination of blinatumomab and inotuzumab ozogamicin (anti-CD22 antibody-drug conjugate) has demonstrated high rates of complete remission and measurable residual disease (MRD) negativity, with manageable toxicity. While chimeric antigen receptor (CAR) T-cell therapy remains a transformative option for relapsed/refractory B-ALL, its integration into frontline treatment is still under investigation. Ongoing trials are evaluating the optimal sequencing and combinations of these agents and their potential to obviate the need for chemotherapy and/or allo-HCT in selected patients. As evidence continues to accumulate, chemo-free and chemo-light regimens, incorporating minimal chemotherapy with targeted agents to balance efficacy and reduced toxicity, are poised to redefine the standard of care for adults BCP-ALL, offering the possibility of durable remissions with reduced treatment-related morbidity
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