969 research outputs found
Biodegradable poly(alpha-hydroxy ester) blended microspheres as suitable carriers for retinal pigment epithelium cell transplantation
No full textFive blends of poly(L-lactic acid) (PLLA) with poly(D,L-lactic-co-glycolic acid) (PLGA) were used to prepare microcarriers by a solvent evaporation technique. Microcarriers were evaluated as suitable scaffolds to facilitate retinal pigment epithelium (RPE) cell transplantation. The blend ratios were 90:10, 75:25, 50:50, 25:75, 10:90 (PLLA:PLGA). Samples of each microcarrier blend were coated with an extracellular matrix protein. Coated and uncoated microcarriers were seeded with a human RPE cell line. As the lactide unit content increased the size of microcarriers generally became larger and the surface more irregular. Cells remained proliferative and retained phenotype as confirmed by immunocytochemistry. Blends rich in PLLA were superior for maintenance of RPE cell viability. This study demonstrates for the first time the feasibility of using microcarriers as a vehicle for retinal cell transplantation for ocular disease.<br/
1924-10-13 (October 13, 1924 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
No full text1920-12-31 (December 31, 1920 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
No full text1924-02-26 (February 26, 1924 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
No full text1921-11-10 (November 10, 1921 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
No full text1921-06-08 (June 08, 1921 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
No full text1921-04-28 (April 28, 1921 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
No full text1921-01-10 (January 10, 1921 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
No full text1924-06-11 (June 11, 1924 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
No full text1925-04-17 (April 17, 1925 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
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