49 research outputs found
A novel gate-staggered ferroelectric DM-JLTFET biosensor with T-channel and L-cavity for label-free cancer biomarker detection
No full textThis work presents a new label-free biosensing technique for detecting Cancer biomarkers in a Ferroelectric Dielectrically Modulated Junction less Tunnel Field-Effect Transistor (FE DM-JLTFET) based on Si: HfO2 that uses an L-shaped nano-cavity and a T-shaped channel. When cancer biomarkers with varying dielectric properties are immobilized within the nanocavities, they alter the local permittivity, which affects the electric field distribution in the Si: HfO2 heterostructure. This change influences the energy band profile and modulates the band-to-band tunneling (BTBT) current utilized for biosensing. The proposed device operates at 2.4 GHz and shows different current responses to different cancer cell lines based on their frequency-dependent permittivity profiles such as Colorectal Cancer (SW 620, K = 3.9 at 0.5 THz), Kidney Cancer (HEK293, K = 4.0 at 0.5 THz), Brain Cancer (U-87 MG, K = 20 at 1.2 GHz, Breast Cancer (MDA-MB-231, K = 22 at 2 GHz) and Osteosarcoma (SaOS-2 (K = 45) 143B (K = 50) at 1 GHz). For the first time, frequency-selective dielectric modulation is used to reliably discriminate between many cancer categories using a single nanoscale transistor sensor. High sensitivity and specificity in detection are made possible by the direct control of the Ion/Ioff ratio by the induced changes in energy bands. Additionally, by increasing tunneling efficiency, gate-staggering amplifies current modulation for better diagnostic resolution. With its ability to identify Colorectal, Kidney, Breast, Brain, and Bone Cancers early and accurately this small affordable and scalable biosensor platform shows great promise for real-time, point-of-care cancer diagnostics
Alternative Approaches to Deep Frying Technology – Their Practical Feasibility and Global Perspectives
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Synthesis and Antimicrobial Activity of Bis(Azolyl) Urea Derivatives
Get PDFA variety of bis(azolyl) urea derivatives were prepared by the reaction of methyl benzazoyl carbamates with azolyl amines in the presence of mild base and studied their antimicrobial activity. The presence of electron donating substituents on the aromatic ring enhanced the activity. Methoxy substituted benzothiazolyl thiazolyl urea, benzothiazolyl imidazolyl urea and benzimidazolyl thiazolyl urea displayed prominent antibacterial activity against Bacillus subtilis. Benzothiazolyl imidazolyl urea and methyl substituted benzimidazolyl imidazolyl urea showed good antifungal activity against Aspergillus niger. © 2019 Author(s)
Implementation of High Security Cryptographic System with Improved Error Correction and Detection Rate using FPGA
Get PDFIn this article, an encryption algorithm with an error detection technique is presented for highly secured reliable data transmission over unreliable communication channels. In this algorithm, an input data is mapped into orthogonal code first. After that the code is encrypted with the help of Linear Feedback Shift Register (LFSR). The technique has been successfully verified and synthesized using Xilinx by Spartan-3E FPGA. The results show that the error detection rate has been increased to 100% by proposed encryption scheme is effective and improves bandwidth efficiency
Complexes of Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) with o-aminobenzoic acid
Get PDF689-692Complexes of o-aminobenzoic acid with Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) have been prepared and characterised by X-ray diffraction patterns, infrared, Mossbauer and photoacoustic spectra. All the complexes -are polymeric and isomorphous with Zn(II) analogue. An analysis of temperature dependence of quadrupole splitting and optical spectral data give the values of ~ 10,840 cm -1, ~ 2930 cm-1, ~ 450 cm-1, ~ 180 cm-1 for 10 Dq, Eg level splitting, tetragonal field and rhombic fields respective y for Fe(OAB)2 system. Mossbauer studies of Fe(OAB)2 indicate that this compound is stable upto 600 K. Ligand field parameters for Ni(II) and Co(II) have been deduced from photo-acoustic spectra
Quercetin does not alter the oral bioavailability of Atorvastatin in rats
No full textAbstract: The study was undertaken to evaluate the effect of Quercetin on the pharmacokinetics of Atorvastatin Calcium. In-vivo Pharmacokinetic studies were performed on rats in a single dose study and multiple dose study. Rats were treated with Quercetin (10mg/kg) and Atorvastatin Calcium (20mg/kg) orally and blood samples were collected at (0) pretreatment and 0.5, 1, 1.5, 2, 2.5, 3, 4, 8, 12, 24 hours post treatment. Plasma concentrations of Atorvastatin were estimated by HPLC method. Quercetin treatment did not significantly alter the pharmacokinetic parameters of atorvastatin like AUC 0-24, AUC 0-α , T max , C max and T 1/2 in both single dose and multiple dose studies of Atorvastatin Calcium. Quercetin does not alter the oral bioavailability of Atorvastatin Calcium in rats
