7 research outputs found
An Infopreneurship Model for Iranian Online Information Businesses
No full textInfopreneurship is the art of entrepreneurship using information and helps infopreneurs to struggle and stand in an arena called fair (bazaar) and make benefits with once they succeed. Hence, this research was conducted with the aim of providing a model for online Infopreneurship in Iran. The present research is an applied one in terms of its purpose, and carried out through quantitative approach and analytical survey method. The statistical population of this study included1835 directors and experts of websites and online businesses across Iran. Sampling was done randomly in through stratified simply class and 320 people were selected using Krejcie and Morgan table. The data collection instrument was a researcher-made questionnaire. Data were analyzed using one-group T-test, Pearson correlation coefficient, analysis of variance and factor analysis.The findings of this study showed that structural, behavioral, field, strategic, and consequential factors are correlated with the correlation coefficient of 0.74, 0.73, 0.75, 0.68 and 0.18 with the variables of Infopreneurship, and were significant at p <0.05. The high middle or high level online business companies include these factors. Eventually, a model of Infopreneurship was represented in relation to online businesses in Iran.Based on the suggested model, it can be concluded that the more the online information businesses in Iran enjoy the identified factors, the more the amount of infopruneurship and its consequences will be, and that such a model can be used as a comprehensive road map for individuals, organizations and online information businesses interested in infopruneurship in Ira
Салафиты в политической жизни Египта
No full textIn today's world Salafism, which has evolved from insignificant and apolitical to the very influential movement is the subject of active discussion. This article discusses and analyzes the historical background, the conditions of formation and propagation of Salafi movement in Egypt. In addition, the author disclosed the role and the place of this movement in modern political life of Egypt.В современном мире салафизм, превратившийся из довольно незначительного и аполитичного движения во влиятельное исламское явление, стал темой активной дискуссии. И это вызывает обеспокоенность в обществе. В данной статье рассматривается и анализируются исторические предпосылки, условия формирования и распространения движения салафитов в Египте. Также раскрывается роль и место этого движения в современной политической жизни Египта
Time and Gender in Charlotte Perkins Gilman’s “The Yellow Wall-Paper” and Kate Chopin’s “The Story of an Hour”
No full textThe aim of this presentation is to show how Charlotte Perkins Gilman and Kate Chopin manipulate temporality to foreground their themes in "The Yellow Wall-Paper" and "The Story of an Hour" in the light of Gerard Genette's theory of time. Both stories present female characters oppressed by the patriarchal authority in the marriage and their attempts to liberate themselves from this oppression. The aim is to find out how the gender of the author or protagonist in the narration can affect the time of narration. Gerard Genette's theory of time (order) is applied to these short stories in order to confirm that the theme of the story affects the time of narration regarding women's status in the narration. The results are in agreement with feminist narratologists who believe that the female authors use techniques of time in the narration purposefully to resist or negotiate with patriarchy in the process of women's liberation.Publisher's Versio
Author Correction: Changes in plant biodiversity facets of rocky outcrops and their surrounding rangelands across precipitation and soil gradients
No full textAssessment of the Psychometric Properties of the Attitude Scale for Nursing Profession (ASNP)
No full textBackground and Objective: The attitude towards the nursing profession is one of the most important topics in all areas of care provision from the time of choosing this profession to the end of the service period. The present study was conducted to determine the psychometric indicators of the Attitude Scale for the Nursing Profession (ASNP).
Materials and Methods: This descriptive methodological study initially obtained permission from the original author to use the tool. The sample included 301 nurses who were selected using the convenience sampling method and working at hospitals affiliated with the Golestan University of Medical Sciences. Following that, the Attitude Scale for Nursing Profession (ASNP) developed by Ipek and Coban was translated into the Persian language according to the International Quality of Life Assessment (IQOLA) protocol. The validity assessment of the scale was carried out using a quantitative and qualitative method based on content validity (Content Validity Ratio [CVR] and Content Validity Index [CVI]) and utilizing the opinions of 11 nursing experts. Moreover, reliability was evaluated by two methods of internal consistency (Cronbach's alpha), test-retest, and the intra-class correlation coefficient (ICC). Data analysis was conducted using exploratory and confirmatory factor analysis in SPSS (version 22) and AMOS (version 23) software.
Results: In the current study, the CVR score of the entire questionnaire was calculated as 0.72; however, statements 16 and 19 scored less than the acceptable level; therefore, they did not have proper validity and were removed. The CVI of all items was more than 0.79. The Cronbach's alpha coefficient of ASNP was obtained at 0.96. The ICC was determined at 0.93, and the stability reliability in the two stages of the test-retest method was 0.789 (P=0.001). The results of exploratory factor analysis showed that the Persian version of the scale has a 3-factor structure (characteristics of the nursing profession, preference for the nursing profession, and the general position of the nursing profession). These factors were confirmed by confirmatory factor analysis. (RMSEA=0.092, AGFA=0.90, and GFI=0.93). The estimation of standard factor loadings in confirmatory factor analysis showed that this scale has an acceptable fit in Iranian culture and has good construct validit.
Conclusion: The results showed that the ASNP has the necessary validity and reliability after removing two items and can be used as a comprehensive and reliable tool to investigate the attitude towards the nursing profession in Iran
Ditylenchus sarvarae Shokoohi & Iranpour & Peneva & Elshishka & Fourie & Swart 2018, sp. n.
No full textDitylenchus sarvarae sp. n. (See Figs. 1 & 2) Measurements. See Table 1. Description. Population from Bam, province of Kerman (4♀♀, 3♂♂): Female. Body almost straight to open “C” shape When heat relaxed. Lip region loW, measuring 7–9 µm in diameter and 3–4 µm in height. Head flattened, appearing almost smooth. Stoma opening pore-like at the centre of a small oral disc. Amphidial openings small and slit-like, posterior to lateral lips. Cuticle annuli about 1 µm Wide at midbody. Stylet delicate, With Well developed, rounded knobs, 2 µm in Width. Dorsal pharyngeal gland orifice (DGO) at 22–25% of stylet length. Pharyngeal procorpus cylindrical, Without a constriction at the junction With median bulb. Median bulb mostly oval in shape, 17–18 µm long and 10–11 µm in diameter, valve Well developed. Isthmus long, slender, encircled nearly at its midpoint by the nerve ring. Nerve ring located at 47–55% of neck length. Basal pharyngeal bulb spatulate. Hemizonid located opposite anterior part of pharyngeal basal bulb at 63– 78% of neck length, about three cuticular annuli long. Excretory pore at basal bulb level, at 73–79% of neck length. Lateral fields With seven plain incisures, often difficult to see under the light microscope. Reproductive system monodelphic-prodelphic, Well developed. Ovary Without flexure toWards vulva. Anterior genital tract 200 µm long, 15–20% of body length, With the apex of the germinal zone not reaching the pharyngeal bulb. Spermatheca broad, elongated, 35–38 µm long, 6–10 µm in diameter, filled With rounded sperm. Anterior part of uterus in the form of a quadricolumella, folloWed by a short, narroWer tract and ending in a sWollen posterior part near the vagina. Postvulval uterine sac Well developed, 1.8–2.8 times the vulval body diameter; 25–51% the vulva–anus distance. Tail conoid, ending in a finely pointed terminus. Phasmids conspicuous, 29–33 µm distant from anus. Male. Smaller than female, but similar in shape, except in reproductive system. Lip region 3–4 µm high, 7–8 µm in diameter, slightly narroWer than the rest of the body. Lip region With 3 annuli. Stylet delicate, knobs small, rounded, 2.0–3.0 µm in diameter. DGO 22–23% of stylet length. Median bulb oval, 18 µm length and 11 µm in diameter, respectively. Isthmus slender, elongate, 60–61 µm long, encircled approximately in the middle by the nerve ring. Basal pharyngeal bulb spatulate, slightly abutting intestine. Lateral fields With seven smooth incisures. Testis Well developed, 544–888 µm long, not reaching the basal bulb. Bursa leptoderan, slightly longer than tail in overall extension, starting anterior to the cloaca at a distance slightly more than one anal body diameter and extending 66–95% of tail length. Spicules ventrally arcuate, slightly cephalated anteriorly. Gubernaculum simple, 30–43% of spicule length. Locality and habitat. The material studied Was isolated from rhizosphere soil associated With alfalfa roots (Medicago sativa L.) in Bam, in the province of Kerman, Iran (N: 29°06′22″; E: 58°21′25″). Type material. TWo females and tWo males (holotype and paratypes) deposited in the National Collection of Nematodes (NCN) at the ARC-PPRI (Nematology Unit of Biosystematics). The other paratypes (tWo females and one male) Were deposited in the nematode collection of Nematology Laboratory of North West University, Potchefstroom, South Africa. Diagnosis. Ditylenchus sarvarae sp. n. is characterized by body length (1000–1438 µm in females and 780– 933 µm in males), stylet length (9–10 µm), number of lateral lines (seven), post uterine sac length (55–62 µm), tail length (73–89 µm in females and 64–69 µm in males), spicule length (22–25 µm), leptoderan bursa (94–95% of tail length) and unique D2D3 sequence. Relationships. The neW species is morphologically similar to D. valveus Thorne & Malek, 1968 and D. destructor Thorne, 1945. Compared With D. valveus, it has a longer bursa (94–95% of tail length vs 23–47% of tail length) (Brzeski 1991). Compared With D. destructor, D. sarvarae sp. n. differs in shape of the tail terminus (sharply pointed vs rounded), number of lateral field insicures (7 vs 6) and a longer bursa (50–90% in D. destructor) (SWart et al. 2015). Compared With D. gigas Vovlas, Troccoli, Palomares-Rius, De Luca, Liébanas, Landa, Subbotin & Castillo 2011, the neW species differs in body length (1000–1438 µm vs 1561–1932 µm in females and 933–1152 µm vs 1373–1716 µm in males), female tail length (68–89 µm vs 69–103 µm), length of postuterine sac (55–62 µm vs 81–150 µm), number of lateral incisures line (7 vs 4) and bursa length (94–95% of tail length vs 50–90% of tail length) (Vovlas et al. 2011). In comparison With D. oncogenus Vovlas, Troccoli, Palomares-Rius, De Luca, Cantalapiedra-Navarrete, Liébanas, Landa, Subbotin & Castillo, 2015 the neW species differ in having more lateral field incisures (7 vs 6) and a longer bursa (62–67% of tail length in D. oncogenus) (Vovlas et al. 2015). Compared With D. gallaeformans Oliveira, Santini, Seni, Dietrich, Salazar, Subbotin, Mundo- Ocampo, Goldenberg & Barreto, 2013, it differs in having more lateral field incsicures (7 vs 4) and shorter bursa (94–95% of tail length vs 100% of tail length). In comparison With D. halictus Giblin-Davis, Erteld, Kanzaki, Ye, Zeng & Center, 2010, it differs in lateral field incisures (7 vs 6) and bursa length (94–95% of tail length vs 20–55% of tail length). The neW species shoWs differences With D. drepanocercus Goodey, 1953 in spicule length (22–26 µm vs 10 µm) and bursa length (94–95% of tail length vs 50% of tail length; according to Brzeski 1991). D. persicus and D. sarvarae differ in body length (vs 635-928 µm in females and 670-715 µm in males), stylet length (vs 5-7 µm), post uterine sac length (69-139 vs 14-18 µm), female tail length (68-98 vs 45-68 µm), the number of lateral field incisures (7 vs 6) and spicule length (22-26 vs 15-17 µm). Etymology. The specific epithet is in honor of the mother, Lady Sarvar Ourang, of the first author in grateful recognition of her efforts to raise him from childhood, and is also dedicated to all mothers in the World. DNA characterization. The sequence flanked by the tWo primers D2a and D2b of the D2–D3 segment of 28S region of D. sarvarae sp. n. contains 762 base pairs (bps). A Blast search demonstrated that this population has 125 base pair differences from the Chinese populations of D. destructor (EU400628, EU400624; EU400623; 83% identity). The Iranian population shoWs less similarity With other Ditylenchus sequnces deposited in the NCBI GenBank.Published as part of Shokoohi, Ebrahim, Iranpour, Fahime, Peneva, Vlada, Elshishka, Milka, Fourie, Hendrika & Swart, Antoinette, 2018, Ditylenchus sarvarae sp. n. (Tylenchina: Anguinidae) from Iran, pp. 197-206 in Zootaxa 4399 (2) on pages 198-204, DOI: 10.11646/zootaxa.4399.2.4, http://zenodo.org/record/120658
Discovery of antiprotozoal compounds from medicinal plants
No full textTropical parasitic diseases such as malaria, human African trypanosomiasis, chagas disease, and leishmaniasis affect hundreds of millions of people worldwide and have devastating consequences. Current drugs available to treat these diseases have serious drawbacks. New drugs are urgently needed.
Natural products (NPs) play a dominant role in drug discovery for the treatment of human diseases. Particularly, quinine and artemisinin have their origin in nature and have inspired successful drugs for malaria treatment.
In a medium throughput screening, a total of 507 extracts from South African plants were assayed for their antiprotozoal activity against Plasmodium falciparum, Trypanosoma brucei rhodesiense, Trypanosoma cruzi and Leishmania donovani. Extracts from Abrus precatorius L. ssp. africanus Verdc. (Fabaceae) and Drypetes gerrardii Hutch. var. gerrardii (Putranjivaceae) inhibited at least one of the parasites at a test concentration considered relevant. With the aim of identifying the compounds responsible for these activities, a HPLC-based activity profiling approach followed by dereplication was applied. Targeted isolation of promising compounds was achieved by a combination of chromatography techniques. Structure elucidation was achieved by HR-ESI-MS and NMR (1H, 13C, COSY, HMBC, HSQC, and NOESY spectroscopy). Absolute configuration was determined by comparison of electronic circular dichroism (ECD) spectra with calculated ECD data.
HPLC-based activity profiling of A. precatorius allowed the identification of abruquinones, as responsible for the trypanocidal activity of the crude extract. A total of ten abruquinones were isolated. Among these were five new compounds. Abruquinone B, I, A, D, K, and L showed remarkable inhibition (0.16 ± 0.060, 0.28 ± 0.051, 0.02 ± 0.003, 0.01 ± 0.001, 0.11 ± 0.053, and 0.02 ± 0.053, respectively) and notable selectivity, expressed as selectivity indices (SIs) which were calculated from cytotoxicity data in L-6 cells (51, 74, 1379, 668, 508, and 374, respectively). These results warrant in vivo assessment of abruquinones.
Abruquinones are promising hits due to their strong and selective in vitro inhibition of T. b. rhodesiense, their good compliance with Lipinski’s “rule-of-5” and other molecular properties, as well as their predicted low/moderate toxic potential.
Two different extracts of D. gerrardii showed antiprotozoal activity, and the active constituents were tracked and isolated by HPLC-based activity profiling. The CH2Cl2/MeOH (1:1) stems extract inhibited L. donovani and P. falciparum. The major compound, a new phenanthrenone, showed good in vitro activity (IC50 of 0.9 ? 0.3 mM) and selectivity (SI of 68) against P. falciparum. Based on these promising results, in-vivo studies were conducted. However, the compound was not able to reduce parasitemia in the P. berghei mouse model. A phenanthrenone heterodimer was also isolated and showed in vitro antiplasmodial activity (IC50 of 2.04 ? 0.15 mM and SI of 31). Furthermore, the CH2Cl2/MeOH (1:1) leaves extract displayed trypanocidal properties, and the known saponin putranoside A was isolated and tested against T. b. rhodesiense, (IC50 of 18.0 ? 3.8 mM and a SI of 4).
The phenanthrenone was the most active and selective in vitro inhibitor of P. falciparum, but showed no inhibition in vivo against P. berghei. However, the compound fulfilled Lipinski’s “rule-of-5” and other molecular properties, which indicates a potential to meet requirements of an ideal antimalarial drug such as, oral bioavailability and blood-brain barrier permeability. According to Medicines for Malaria Venture compound progressing criteria, the phenanthrenone complies with some of the features of a validated hit such as sufficient activity against P. falciparum in vitro (? 1 ?M).
Additionally, as part of a project aimed at investigating antiprotozoal European plants Chrysanthemum cynerariifolium (Trevir.) Vis. (Asteraceae), Laurus nobilis L. (Lauraceae), and Eupatorium cannabinum L. (Asteraceae) were studied. A hexane extract of C. cynerariifolium showed promising activity against P. falciparum. Pyrethrins (irregular monoterpenes) were the metabolites responsible for the antiplasmodial activities. Particularly, pyrethrin II and jasmolin II inhibited P. falciparum (IC50 4.0 ? 1.1 ?M and 5.0 ? 0.4 ?M, respectively and SI of 24 and 6, respectively) in vitro. Synthetic pyrethroids were also tested, but they did not show activity.
Finally, as a contribution to the structure activity relationship study of sesquiterpene lactones showing activity against T. b. rhodesiense, costunolide and zaluzanin D were isolated from Laurus nobilis L. (Lauraceae) and eupatoriopicrin from Eupatorium cannabinum L. (Asteraceae). Germacrolides, i.e. costunolide and eupatoriopicrin, showed a higher inhibition (IC50 of 1.3 ? 0.4 mM and 1.2 ± 0.2 mM, respectively) on the protozoon, than the guaianolide zaluzanin D (IC50 of 10.8 mM).
In brief, a total of 22 secondary metabolites were isolated from five species. Among them, seven new compounds were discovered. These compounds belong to the structural classes of isoflavonoids, phenanthrenones, and terpenes such as, sesquiterpene lactones, irregular monoterpenes and triterpenoid saponins. Most of them (15 compounds) exhibited in vitro antiprotozoal activity. The most promising compounds were the abruquinones and the phenanthrenone, which strongly and selectively inhibited T. b. rhodesiense and P. falciparum, respectively. Abruquinones and the phenanthrenone are drug-like compounds with a calculated toxic potential ranging from low to moderate.
ZUSAMMENFASSUNG
Tropische parasitäre Krankheiten wie Malaria, afrikanische Trypanosomiasis (Schlafkrankheit), Chagas-Krankheit und Leishmaniose betreffen Hunderte von Millionen Menschen weltweit und haben verheerenden Folgen. Aktuelle Medikamente, die zur Behandlung dieser Krankheiten zur Verfügung stehen, haben gravierende Nachteile. Neue Medikamente werden dringend benötigt.
Naturstoffe (NP) spielen eine dominierende Rolle in der Wirkstoffforschung für die Behandlung von menschlichen Erkrankungen. So haben Chinin und Artemisin ihren Ursprung in der Natur und führten zu erfolgreichen Medikamenten zur Malariabehandlung.
In einem mittleren Durchsatz-Screening wurden insgesamt 507 Extrakte von südafrikanischen Pflanzen auf ihre Aktivität gegen Protozoen - Plasmodium falciparum, Trypanosoma brucei rhodesiense, Trypanosoma cruzi und Leishmania donovani - getestet. Extrakte von Abrus precatorius L. ssp. africanus Verdc. (Fabaceae) und Drypetes gerrardii Hutch. var. gerrardii (Putranjivaceae) haben mindestens einen der Parasiten in einer als relevant bezeichneten Testkonzentration gehemmt.
Mit dem Ziel die für diese Aktivitäten verantwortlichen Verbindungen zu identifizieren wurde ein Ansatz bestehend aus HPLC-basiertes Aktivitäts-Profiling gefolgt von Dereplikation verwendet. Gezielte Isolierung der vielversprechenden Verbindungen erfolgte durch eine Kombination von Chromatographie-Techniken. Die Strukturaufklärung wurde durch HR-ESI-MS und NMR (1H, 13C, COSY, HMBC, HSQC, und NOESY Spektroskopie) durchgeführt. Die absolute Konfiguration wurde durch den Vergleich der elektronischen Zirkulardichroismus-(ECD)-Spektren mit berechneten ECD-Daten bestimmt.
HPLC-basiertes Aktivitäts-Profiling von A. precatorius ermöglichte die Identifizierung von Abruquinonen, als verantwortliche Substanzen für die trypanozide Aktivität des Rohextrakts. Es wurden insgesamt 10 Abruquinone isoliert, darunter fünf neue Verbindungen. Abruquinone B, I, A, D, K und L zeigten bemerkenswerte Hemmung (0.16 ± 0.060, 0.28 ± 0.051, 0.02 ± 0.003, 0.01 ± 0.001, 0.11 ± 0.053, und 0.02 ± 0.053) und beachtenswerte Selektivität, wiedergegeben als Selektivitätsindizes (SIs) die aus der Zytotoxizität in L-6 Zellen (51, 74, 1379, 668, 508, und 374) ermittelt wurden.
Wegen ihrer starken und selektiven in vitro Hemmung von T. b. rhodesiense, ihrer guten Übereinstimmung mit Lipinski’s „5er Regel“ und anderen molekularen Eigenschaften, sowie ihrem niederen/mässigen toxischen Potenzial sind Abruquinone vielversprechende Hits. Deshalb sind weitere Studien notwendig um botanische oder chemische Quellen sicherzustellen und die in-vivo Wirksamkeit dieser Verbindungen zu bestimmen.
Zwei verschiedene Extrakte von D. gerrardii zeigten Aktivität gegen Protozoen. Die aktiven Bestandteile wurden mit Hilfe vom HPLC-basiertem Aktivitäts-Profiling identifiziert und isoliert. Der CH2Cl2/MeOH (1:1) Extrakt aus den Stängeln hemmte L. donovani und P. falciparum. Die Hauptverbindung, ein neues Phenanthrenon, zeigte gute in vitro Aktivität (IC50 von 0.9 ? 0.3 mM) und Selektivität (SI von 68) gegen P. falciparum. Basierend auf diesen vielversprechenden Resultaten wurden in vivo Studien durchgeführt. Allerdings war diese Verbindung nicht in der Lage die Parasitenbelastung im P. berghei Mausmodell zu reduzieren. Es wurde ebenfalls ein Phenanthrenon-Heterodimer isoliert, der in vitro Aktivität gegen Plasmodien (IC50 von 2.04 ? 0.15 mM und SI von 31) aufwies. Ausserdem zeigte der CH2Cl2/MeOH (1:1) Blattextrakt ausgewiesene trypanozidale Eigenschaften. Aus diesem Extrakt wurde das bekannte Saponin Putranoside A isoliert und gegen T. b. rhodesiense, (IC50 von 18.0 ? 3.8 mM und SI von 4) getestet.
Das Phenanthrenon war der aktivste und selektivste in vitro Inhibitor von P. falciparum, zeigte jedoch keine Hemmung in vivo gegen P. berghei. Die Verbindung erfüllte jedoch Lipinski’s „5er Regel“ und andere molekulare Eigenschaften, wie orale Bioverfügbarkeit und Durchlässigkeit der Blut-Hirn-Schranke, was ein mögliches Potenzial aufzeigt den Anforderungen eines idealen Antimalariawirkstoffs gerecht zu werden. Nach „Medicines for Malaria Venture“-Kriterien für die weitere Entwicklung eines Wirkstoffs erfüllt das Phenanthrenon einige der Merkmale eines validierten Hits wie ausreichende in vitro Aktivität gegen P. falciparum (? 1 ?M).
Als weiterer Teil des Projekts wurde die Wirkung von europäischen Heilpflanzen Chrysanthemum cynerariifolium (Trevir.) Vis. (Asteraceae), Laurus nobilis L. (Lauraceae), und Eupatorium cannabinum L. (Asteraceae) gegen Protozoen studiert. Ein Hexan-Extrakt von C. cynerariifolium zeigte vielversprechende Aktivität gegen P. falciparum. Phyrethrine (unregelmässige Monoterpene) waren die Inhaltsstoffe verantwortlich für die antiplasmodiale Aktivität. Besonders Pyrethrin II und Jasmolin II hemmten P. falciparum (IC50 4.0 ? 1.1 ?M und 5.0 ? 0.4 ?M, und SI von 24 und 6) in vitro. Es wurden auch synthetische Pyrethroide getestet, sie zeigten aber keine Aktivität.
Schliesslich, als Beitrag zu den Struktur-Aktivitätsuntersuchungen von Sesquiterpenlactonen mit Aktivität gegen T. b. rhodesiense, wurden Costunolid und Zaluzanin D aus Laurus nobilis L. (Lauraceae) und Eupatoriopicrin aus Eupatorium cannabinum L. (Asteraceae) isoliert. Germacrolides, d.h. Costunolid und Eupatoriopicrin, zeigten eine höhere Hemmung (IC50 von 1.3 ? 0.4 mM und 1.2 ± 0.2 mM) auf Protozoen als das Guaianolid Zaluzanin D (IC50 von 10.8 mM).
Es wurden insgesamt 22 Sekundärmetaboliten aus fünf Arten isoliert, darunter sieben neue Verbindungen. Diese Substanzen gehören zu den Strukturklassen der Isoflavonoide, Phenanthrenone und Terpene einschliesslich Sesquiterpenelactone, unregelmässige Monoterpene und Triterpenoidsaponine. Die meisten von ihnen (15 Verbindungen) zeigten in vitro Aktivität gegen Protozoen. Die vielversprechendsten Verbindungen waren die Abruquinone und das Phenanthrenon, die starke und selektive Hemmung gegen T. b. rhodesiense und P. falciparum zeigten. Abruquinone und das Phenanthrenon sind drug-like Verbindungen mit einem rechnerischen toxischen Potential von gering bis mässig
