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    DEFINITIONS, EPIDEMIOLOGY AND PREDISPOSING FACTORS

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    Endocarditis is defined as the inflammation of the endocardium, the inner layer of the heart, mainly affecting heart valve leaflets, The term endocarditis was introduced for the first time in the scientific community by Sir William Osler who studied a series of 209 cardiac infections of different origins and delivered a Lecture at the Royal College of Physicians in London on "Malignant Endocarditis" in March 1885

    ETIOLOGY.

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    Infective endocarditis [IE] is the final manifestation of a complex series of events ranging from the damage at the level of endocardium to the ultimaate infection of a distinct endocardial lesion by bacteria or fungi. Microorganisms infecting the endoardium may originate from distant sources of infection or through cutaneous or mucosal breaches that allow pathogens to enter and spread into bloodstream
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