1,720,972 research outputs found
La patologia tendinea: fisiopatologia, nuove strategie diagnostiche e terapeutiche
Full text linkThe following thesis is a summa of several research projects and insights around the tendon tissue: first the pathophysiology has been discussed, then the nutraceuticals as prevention strategy. Follows a deep discussion about the role of growth factors in tendon physiology and pathology, finding in the PRP (platelet rich plasma) and PRFM (platelet rich fibrin matrix) a novel and interesting therapy. It has been investigated through a preclinical study comparing and ex vivo model and a quantitative and qualitative assay to identify how the different growth factors may be involved in the tissue repair. At last, a clinical part (diagnostics) has been investigated presenting the results of a study on Achilles tendon evaluated with a novel ultrasound device, the real time elahstosonography: normal achilles tendon of health volunteers has been compared with ruptured ones undergone surgery to assess structural and biomechanics differences
Late-diagnosed large osteochondral fracture of the lateral femoral condyle in an adolescent: a case report.
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Arthroscopic Knee Cartilage Repair with covered Microfracture and bone marrow concentrate
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Arthroscopic management of heterotopic ossification of the subscapularis tendon in a patient with tuberculosis: a case report. J Shoulder Elbow Surg.
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Chitosan stabilizes platelet growth factors and modulates stem cell differentiation toward tissue regeneration
No full textThe idea of using chitosan as a functional delivery aid to support simultaneously PRP, stem cells and
growth factors (GF) is associated with the intention to use morphogenic biomaterials to modulate the
natural healing sequence in bone and other tissues. For example, chitosan–chondroitin sulfate loaded
with platelet lysate was included in a poly(d,l-lactate) foam that was then seeded with human adiposederived
stem cells and cultured in vitro under osteogenic stimulus: the platelet lysate provided to the
bone tissue the most suitable assortment of GF which induces the osteogenic differentiation of the mesenchymal
stem cells. PDGF, FGF, IGF and TGF- were protagonists in the repair of callus fractures. The
release of GF from the composites of chitosan–PRP and either nano-hydroxyapatite or tricalcium phosphate
was highly beneficial for enhancing MSC proliferation and differentiation, thus qualifying chitosan
as an excellent vehicle. A number of biochemical characteristics of chitosan exert synergism with stem
cells in the regeneration of soft tissu
Single-stage cartilage repair in the knee with microfracture covered with a resorbable polymer-based matrix and autologous bone marrow concentrate.
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