1,721,178 research outputs found
GEOSITES INVENTORY IN LIGURIA (NORTHERN ITALY): ACTIVATION PHASES AND ITS POSSIBLE FUTURE DEVELOPMENTS.
No full textLA SALVAGUARDIA DEL PATRIMONIO GEOLOGICO. SCELTA STRATEGICA PER IL TERRITORIO. L'ESPERIENZA IN LIGURIA.
No full textInflammatory/infectious cutaneous side effects of biological drugs in patients with psoriasis: a general review with personal data
No full textIn recent years, the use of biologic drugs has greatly changed the therapy of psoriasis and psoriatic arthritis, but they have some adverse effects. In particular, skin lesions induced by anti-tumor necrosis factor (TNF) and anti-interleukin (IL) 12/23 drug (ustekinumab) have been reported with an increased incidence, highlighting the importance of the skin as a major target of the side effects of these drugs. There is a wide spectrum of skin lesions of different morphology and etiology that includes skin lesions directly related to drug administration, the development of cutaneous immune-mediated conditions and cutaneous infections. The aim of this review is to revisit the literature data on inflammatory/infectious skin adverse effects of biologics both anti-TNF-α inhibitors and anti-IL 12/23 antagonists and to report and update our personal data on inflammatory/infectious side effects in patients with psoriasis/psoriatic arthritis treated with biologics
A general-purpose analytical model for reconstructing the thunderstorm outflows of travelling downbursts immersed in ABL flows
No full textA “downburst” is defined as a diverging wind system that occurs when a strong downdraft induces an outflow of damaging winds on or near the ground. Severe wind damage in many parts of the world are often due to thunderstorm outflows and their knowledge is therefore relevant for structural safety and design wind speed evaluation. Nevertheless, there is not yet a shared model for thunderstorm outflows and their actions on structures. In this paper, an analytical model that simulates the horizontal mean wind velocity originated from a travelling downburst is proposed. The horizontal wind velocity is expressed as the vector summation of three independent components: the stationary radial velocity generated by an impinging jet over a flat surface, the downdraft translating velocity, which corresponds to the parent cloud motion, and the boundary layer background wind field at the surface where the downburst is immersed. A parametric analysis is also developed and coupled with the analytical model aiming to investigate two observed downburst events and extract their main parameters – e.g. downdraft diameter, touch-down position, translating downdraft speed and direction, intensity and decay period - in order to reconstruct the space-time evolution of these events and validate the model itself
THE GEOLOGICAL-GEOMORPHOLOGICAL FEATURES RELATED TO THE ITALIAN SITES IN THE UNESCO WORLD HERITAGE LIST.
No full textInflammatory/infectious cutaneous side effects of biological drugs in patients with psoriasis: a general review with personal data
No full textIn recent years, the use of biologic drugs has greatly changed the therapy of psoriasis and psoriatic arthritis, but they have some adverse effects. In particular, skin lesions induced by anti-tumor necrosis factor (TNF) and anti-interleukin (IL) 12/23 drug (ustekinumab) have been reported with an increased incidence, highlighting the importance of the skin as a major target of the side effects of these drugs. There is a wide spectrum of skin lesions of different morphology and etiology that includes skin lesions directly related to drug administration, the development of cutaneous immune-mediated conditions and cutaneous infections. The aim of this review is to revisit the literature data on inflammatory/infectious skin adverse effects of biologics both anti-TNF-α inhibitors and anti-IL 12/23 antagonists and to report and update our personal data on inflammatory/infectious side effects in patients with psoriasis/psoriatic arthritis treated with biologics
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