317 research outputs found
The next generation of novel therapies for the management of relapsed multiple myeloma
No full textThe advent of various novel therapies such as immunomodulators and proteasome inhibitors has transformed the treatment paradigm for patients with multiple myeloma (MM). As a result, the overall survival has improved dramatically over the last decade. Despite these advances, MM remains mostly incurable and most patients experience disease relapse after enjoying a period of disease control or remission. Fortunately, the scientific community continues to make strides in developing 'next-generation' therapies for the management of patients with relapsed MM. This review will summarize the efficacy of some of the newest therapeutic agents available for the treatment of patients with relapsed MM after their upfront treatment with the original novel agents such as thalidomide, lenalidomide and bortezomib
The legislature and good governance from a human rights perspective: a comparative study of Ghana and South Africa
Get PDFUnder the supervision of Prof. Frans Viljoen, Centre for Human Rights, University of PretoriaThesis (LLM (Human Rights and Democratisation in Africa)) -- University of Pretoria, 2002."The study is divided into six chapters. Chapter one introduces the study, by looking at the background factors contributing to the poor governance in Africa. The chapter sets off with the problem, objective, and motivation of the study. The chapter sets out the hypotheses of the study, the methodology used, and the review of the available literature. The chapter concludes with the clarifications of concepts used in the study. Chapter two makes a brief background legislative history by looking at the past constitutional frameworks and the political systems that might have influenced the Legislatures of the two countries. The chapter continues with the current constitutional frameworks of both countries and examines the Legislatures established under them. Chapter three starts with the crux of the study - the roles of both Legislatures and delves into their representation and participation roles. The chapter assesses the medium of representation and extent to which the general public gets involved and participates in the deliberations of the LG and LSA. Chapter four looks at the law-making role. The chapter looks into how through legislaiton both Legislatures flesh out their constituitonal values to create more tangible boundaries within which their citizens conduct their lives. Chapter five looks into the oversight role over the executive. The chapter looks into the mechanisms in place to oversee the executive, and to hold them to account on their performances. Chapter six concludes the study with a summary. It makes a comparative analysis of the LG and LSA. The chapter tests the hypotheses of the study. It looks also at the challenges of both Legislatures. The chapter concludes with recommendations aimed at effective performance of the Legislature in Ghana and South Africa." -- Chapter 1.http://www.chr.up.ac.za/academic_pro/llm1/dissertations.htmlCentre for Human RightsLL
Baseline characteristics of patients with AL cardiac amyloidosis.
No full textData are presented as medians (25th, 75th quartiles) or as percentages, as appropriate. ^ Kumar S, Dispenzieri A, Lacy MQ, Hayman SR, Buadi FK, Colby C, et al. Revised prognostic staging system for light chain amyloidosis incorporating cardiac biomarkers and serum free light chain measurements. Journal of clinical oncology 2012;30(9):989–95. Nine (29%) patients had missing NT-proBNP levels at baseline, thus precluding the calculation of cardiac prognostic stage. # Palladini G, Hegenbart U, Milani P, Kimmich C, Foli A, Ho AD, et al. A staging system for renal outcome and early markers of renal response to chemotherapy in AL amyloidosis. Blood. 2014;124(15):2325–32. Eight (26%) patients had missing urine-24 hour protein assessment at baseline, thus precluding the calculation of renal stage. Abbreviations: AL, immunoglobulin light-chain. (DOCX)</p
Revisiting global development frameworks and research on universal basic education in Ghana and Sub‐Saharan Africa: a review of evidence and gaps for future research
No full textA validated composite organ and hematologic response model for early assessment of treatment outcomes in light chain amyloidosis
No full textNewly diagnosed AL amyloidosis patients were evaluated to develop a model for early assessment of treatment benefit at 6 months, integrating both hematologic (HR) and organ response (OR) assessment (testing cohort, Mayo: n = 473; validation cohort, Pavia: n = 575). Multiple OR were assessed as follows: All OR (AOR): response in all organs, mixed OR (MOR): response in some organs, no OR (NOR)]. AOR rates at 6 months improved with deepening HR; complete response (CR; 38%, 35%), very good partial response (VGPR; 30%, 26%), and partial response (PR; 16%, 21%), respectively. A composite HR/OR (CHOR) model was developed using incremental scoring based on hazard ratios with scores of 0–3 for HR (0—CR, 1—VGPR, 2—PR, 3—no response) and 0–2 for OR (0—AOR, 1—MOR, 2—NOR). Patients could be divided into two distinct CHOR groups (scores 0–3 and 4–5), with median OS in group 1 and group 2: Not reached vs. 34 months, p < 0.001 [Mayo] and 87 vs. 23 months, p < 0.001 [Pavia]. In conclusion, we developed a model that can assess multiple organs concurrently, and integrate both HR and OR assessments to determine early clinical benefit with treatment, which may be used as a surrogate end-point in trials and to compare outcomes with different therapies
Asymptomatic immunoglobulin light chain amyloidosis (AL) at the time of diagnostic bone marrow biopsy in newly diagnosed patients with multiple myeloma and smoldering myeloma. A series of 144 cases and a review of the literature
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