1,721,161 research outputs found
Atrophoderma vermiculatum: Histological findings of the early and late lesions. Study of a case
No full textAtrophoderma Vermiculatum (AV) is a rare disease characterized by the occurrence on the face and the cheeks in particular, of fine, atrophic pits, with a bilateral distribution, producing a honeycomb, reticulate appearance. All the cases reported in the literature focus on the atrophic changes of the disease while no attention has been paid to the condition which causes atrophy. The early stages are not usually reported. MC is a girl aged 13. She had multiple, fine, pale-brown papules (1-2 mm in diameter) on her right cheek. The histopathological findings of these lesions predominantly showed lymphocytic perifolliculitis with perifollicular fibrosis. The epidermis was normal. No specific diagnosis other than perifolliculitis was possible. Eight months later the patient showed tiny, atrophic depressions and follicular plugs with reticulate teleangectases in the same area of the right cheek (with disappearance of the tiny papules). A clinical diagnosis of AV was done. The histological findings of a further biopsy showed atrophy of the epidermis, less severe perifollicular inflammation and decrease in number of the follicles. The hair follicles were widely dilated and were either empty or contained keratinous materials. Dermal atrophy and disappearance of elastic fibers was noticeable. In conclusion the late clinical features of the lesions, through unusual (asymmetry of the lesion, small and superficial atrophic scars), make the diagnosis of the early clinical and histological features of papules and perifolliculitis possible and suggest a specific name: Early stages of AV
Panniculitis in children
No full textThis paper will give a comprehensive view of the most frequent panniculitides seen in childhood, with emphasis on the types exclusively found in infancy, and for all other types of panniculitides also found in adults. Aim of this paper is also to analyze the clinical differences between panniculitis in childhood and in adulthood, and to give reliable histopathologic criteria for a specific diagnosis. A review of the literature is here integrated by authors' personal contribution. Panniculitides in children is a heterogeneous group of diseases, as well as in adult life, characterized by inflammation of the subcutaneous fat. Only very few types of panniculitis are exclusively found in childhood, such as Sclerema neonatorum and subcutaneous fat necrosis of the newborn, while the vast majority of the other types may be found both in paediatric age and in adults. Furthermore, this paper will consider in detail panniculitis according to their frequency, such as Erythema nodosum, Lupus panniculitis, Cold panniculitis, panniculitis in Behçet disease, and poststeroid panniculitis. It will also describe rare forms of panniculitis, such as Eosinophilic panniculitis (a pathological entity debated by many authors), Subcutaneous panniculitis T-cell lymphoma, and the different forms of the so call "Lipophagic panniculitis", encompassing respectively the febrile relapsing panniculitis of Weber-Christian disease and the non-relapsing form of Rothmann-Makai disease. For each type of panniculitis considered concise information will be given about epidemiology, etiology, clinical findings, laboratory data, prognosis and therapy, while histopathologic findings will be described in detail
Nodular fasciitis: Dermo-hypodermal type. A case report
No full textA case of nodular fasciitis is described. The lesion was located on the right cheek of a 20-year old girl. Histologically the lesion was characterized by an uncapsulated nodule within the dermis and the subcutaneous tissue; it consisted of bundles of spindle and stellate fibroblasts arranged in a loosely intercellular matrix and of proliferation of small capillaries at the edges of the nodule. Moreover problems of differential diagnosis due to the unusual site and unusual clinical aspect are discussed
Cutaneous blisters as the presenting signs of recurrent thyroglossal duct cyst in a child
No full textBrown recluse (L. rufescens) can bite in Northern Italy, too: First case report and review of the literature
No full textThe brown recluse, or fiddleback (violin) spider, is a poisonous spider of the Loxosceles genus that resides in warmer regions and old structures making the warm Mediterranean climate a natural habitat for the European species, L. rufescens. Even in infested households, however, bites are rare, as they are nocturnal and unaggressive. In 2015, the first supposed death by L. rufescens occurred in Italy, but before and even after such bite, the literature on these spiders has been under-represented. This case report documents a confirmed bite by a violin spider on a medical student in Pavia, Italy. The presentation in this case was initially with general systemic, flu-like symptoms, then as cellulitis with lymphangitis that persisted for nearly 2 weeks until resolving without prolonged or complicated pathology. We present the first documented case of a L. rufescens bite in Northern Italy, to the best of our knowledge
Tyrosine kinase inhibitors: Muco-cutaneous side effects at the microscope
No full textIn the past recent years, treatments that target receptors with kinase activity, involved in the transmission of neoplastic proliferation signals, had revolutionized cancer therapy. Imatinib mesylate has been the first of this novel family of drugs approved for the treatment of hematologic malignancies. Afterwards, other second-generation kinase inhibitors, such as dasatinib and nilotinib, have been introduced to circumvent resistance to imatinib. These target therapies have a better tolerability profile than standard chemotherapy, but their range of activity is not simply directed at tumor cells, and a wide spectrum of systemic side effects is now recognized. In particular, muco-cutaneous side effects represent the most frequent non-hematological adverse events. Due to the need of a prompt recognition of these toxicities, diagnosis is usually made on clinical grounds, and an accurate histological characterization is generally lacking. The aim of this paper was to focus on the histopathological findings of cutaneous reactions related to tyrosine kinase inhibitors use. We propose a differentiation between specific and non-specific cutaneous side effects, through an analysis of the possible etiopathogenetic mechanisms of actions of the drug, clinical aspects and major histological features. A review of the literature has been integrated by our personal experience, highlighting the importance of clinico-histological correlation, necessary to make a proper diagnosis
Secondary erythromelalgia: A tryptophan dietary supplement-induced case associated with elevated 5-hydroxyindoleacetic acid (5HIAA) urinary levels
No full textLong-term narrowband UVB phototherapy in vitiligo: Good results are correlated with a long period of continuous and constant therapy
No full textAim. The treatment of vitiligo remains a challenge. In literature various treatment modalities have been proposed. In the present study a long-term narrowband UVB (UVB-NB) approach to vitiligo is proposed in 25 patients. Methods. Treatment frequency was twice a week, on 2 non-consecutive days; treatment was continued for 1 year or discontinued earlier, in case of satisfactory or even complete repigmentation. Photographs of the body surface interested by vitiligo were taken before, during and after treatment; phototherapy responses were expressed as more than 75% repigmentation (group A); between 26% and 75% repigmentation (group B); less than 25% repigmentation (group C) and not responders (group D). Results. At the end of the study (12 months), 11 patients (44%) showed an excellent repigmentation (group A); 8 patients (32%) had a satisfactory good repigmentation (group B); 2 patients (8%) had an unsatisfactory response (group C), and 4 patients (16%) were not responders (group D). The best response was achieved by those patients who had recent vitiligo (100% of patients in group A and 70% of patients in group B). Conclusion. This study suggests that UVB-NB therapy represents a valuable and safe option for vitiligo and confirms that good results are correlated with a long period of continuous therapy; moreover, further improvement could be observed when UVB-NB therapy was prolonged till the end of the first year of treatment or more
- …
