1,477 research outputs found
Isolation of rat liver tRNAArg, tRNALys, tRNAMet, and tRNAPro Isoacceptor species by H.P.L.C
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Isolation of rat liver tRNAAsp, tRNACys, tRNATyr, and tRNAVal isoacceptor species by HPLC
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Isolation of rat liver tRNAAla, tRNAGly, tRNAHis, and tRNAIleu isoacceptor species by HPLC
No full textBilateral spontaneous dissection of the internal carotid arteries.
No full textSpontaneous dissections of the carotid or vertebral artery are an important cause of ischemic stroke in young and middleaged patients, accounting for 10–25% of such cases (Schievink, 2001).
Between 9 and 21% of carotid dissectionsare bilateral (Zetterling et al., 2000)
and the involvement of more than one artery suggests the presence of a transient arteriopathy. Current histological and biochemical data do not suggest only one form of disease, but rather various extracellular
matrix abnormalities which may involve one of the fibrillar components or
their enzymatic regulation
Isolation of rat liver tRNA(Asn), tRNA(Leu), and tRNA(Ser) isoacceptor species by H.P.L.C
No full textTumor Necrosis Factor-a Neutralizing Antibodies Induced by a Glycolaldehyde-Modified C- terminal Polypeptide.
No full textTNF-a is a pro-inflammatory cytokine that is overexpressed in diverse inflammatory states such as rheumatoid arthritis. Anti-TNF therapies, including monoclonal antibodies (Abs), have demonstrated remarkable success in management of arthritis and other chronic inflammatory diseases. The possibility to elicit autoAbs to TNF-a (beneficial autoimmunity) has been proposed as an immunotherapeutic approach to neutralize systemic TNF-a (1). Studies using a DNA vaccination strategy in rat adjuvant arthritis mapped several epitopes for natural anti-TNF-a autoAbs in the C-terminal portion of the sequence. We previously showed that aldehyde-tagged peptide conjugates representing immunogenic epitopes of toxic shock syndrome toxin–1, could induce anti-toxin neutralizing Abs without the need of potent adjuvants (2). In the present study, using a C-terminal TNF-a recombinant polypeptide, we followed a similar approach to generate neutralizing Abs against TNF-a in Lewis rats. Immunized rats showed less severe symptoms in the collagen induced arthritis ( CIA) model.
1. Dalum I. et. al. Therapeutic antibodies elicited by immunization against TNF-alpha. Nat Biotechnol 1999. 17:666-669.
2. Bavoso A, Ostuni A, De Vendel J, Pollaro F, Armentano F, Knight T, Makker S. and A. Tramontano. Aldehyde modification of peptide immunogen enhances protein-reactive antibody response to toxic shock syndrome toxin-1. J Pept Sci 2006. 12:843-849
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