518 research outputs found
Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo
No full textThe mechanisms by which bone resorbing osteoclasts form and are activated by hormones are poorly understood. We show here that the generation of oxygen-derived free radicals in cultured bone is associated with the formation of new osteoclasts and enhanced bone resorption, identical to the effects seen when bones are treated with hormones such as parathyroid hormone (PTH) and interleukin 1 (IL-1). When free oxygen radicals were generated adjacent to bone surfaces in vivo, osteoclasts were also formed. PTH and IL-1-stimulated bone resorption was inhibited by both natural and recombinant superoxide dismutase, an enzyme that depletes tissues of superoxide anions. We used the marker nitroblue tetrazolium (NBT) to identify the cells that were responsible for free radical production in resorbing bones. NBT staining was detected only in osteoclasts in cultures of resorbing bones. NBT staining in osteoclasts was decreased in bones coincubated with calcitonin, an inhibitor of bone resorption. We also found that isolated avian osteoclasts stained positively for NBT. NBT staining in isolated osteoclasts was increased when the cells were incubated with bone particles, to which they attach. We confirmed the formation of superoxide anion in isolated avian osteoclasts using ferricytochrome c reduction as a method of detection. The reduction of ferricytochrome c in isolated osteoclasts was inhibited by superoxide dismutase. Our results suggest that oxygen-derived free radicals, and particularly the superoxide anion, are intermediaries in the formation and activation of osteoclasts
Letter from B.F. Wardlaw to George Sibley, September 14, 1837
No full textPrimary Figures: B.F. Wardlaw corresponds with Major Sibley regarding the administration of the estate of the deceased Miss Fulton.
Date: The correspondence is dated September 14, 1837.
Key Events: Wardlaw protests a request to pay a fifty dollar balance standing on a subscription paper against the Fulton estate, noting that a court judgment on the matter had not yet occurred.
Archival Significance: The author argues that the Church failed to conduct temporal matters according to the Article of Agreement, asserting that this breach releases the estate from further pecuniary liability
The social construction of meaning : Reading Animal Farm in the classroom
No full textThe novel, it has generally been assumed, was from its very beginnings a literary form designed to be read by solitary, silent individuals. One consequence of this assumption is that the class novel, read amid all the noise and sociality of the classroom, tends to be treated as a preparation formore authentic, private reading, or even as poor substitute for it. This essay argues that the history of novel-reading is more complicated and more varied than has been assumed; it goes on to explore, through the story of a single lesson, the possibilities for meaning-making that are the product of particular pedagogic practices as well as of the irreducibly social process of reading the class novel
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Folder 10: B.F. Maiz - Some Winter Words - Author, 1989
No full textFlyer for the Fall Letters Series featuring author B. F. Maiz and his new book 'Some Winter Words.' The event is hosted by the Junior Black Academy of Arts and Letters on November 4, 1989 at the Dallas Convention Center Complex
MANOVA modelling of a chiropractic longitudinal study using multiple imputation
No full textThe purpose of this report is to present the detailed statistical analysis of a randomised, placebo-controlled trial comparing two different treatment modalities to an intervention of no known benefit for people with acute or subacute thoracic spine pain.
The therapy arms consist of Spinal Manipulative Therapy (SMT) and Graston Technique (GT) and the placebo is a non-functional ultrasound. A placebo group was utilised because at present there are no proven treatments for non-specific thoracic pain. This trial is registered with the Australia and New Zealand Clinical Trials Registry. Ethics approval has been granted by Murdoch University Human Research and Ethics Committee, number 2007/274.
The aim of this three arm trial was to test the efficacy of SMT and GT as independent modalities compared to detuned ultrasound for the outcomes of pain and disability. The latter were measured using the Visual Analogue Scale (VAS) and a modified Oswestry Back Pain Disability Index. The study was conducted at the Murdoch University Chiropractic student clinic in Perth, Australia, and the protocol published in Crothers et al (2008).
In this report, Section 2 provides an initial exploratory analysis of the data, Section 3 outlines the statistical models used in the final analysis, Section 4 defines these models in mathematical terms, Section 5 discusses the management of missing values via multiple imputation and Section 6 presents the results of the statistical modelling and hypothesis tests. The clinical study will be published in full elsewhere
The first annual meeting of the Kentucky Baptist Historical Society ... June 14th, 1904 : so much of the exercises of the evening as pertain to the life of Rev. James Madison Pendleton are here preserved ...
No full textby Mr. and Mrs. B.F. Procto
Airline and Alliance Networks: Topology and Robustness from a Complex Network Approach
No full textIncreased market deregulation and the accompanied rise of LCCs over the last decades has put profit for many of the old FSCs under pressure forcing them to merge and form alliances. This sparked the research into finding the most efficient structure for a single airline network in terms of profit and passenger mobility. Along with this, the social and economical dependancy on air transport grew and hence the need to assess the robustness of the network rose. Complex network theory offers a way to assess the efficiency of the networks using amongst other the degree (distribution), the betweenness, the average path length and the clustering coefficient. The main focus of current literature is on the analysis of global and regional airport networks, with limited coverage of separate airline networks and codeshare and alliance formation. Furthermore current research uses very standardized methods of assessing robustness and more realistic assumptions are needed. The first aim of this study is to get an insight into the differences in structure of FSCs and LCCs by analyze the topology and robustness of 17 European separate airline networks, using complex network theory. The second aim is to investigate the influence of codeshare and alliance formation on the topology and robustness of ATNs. Finally the third aim is to improve the methods used to analyze the robustness of ATNs. First the topology of the seperate airline networks of both FSCs and LCCs is analyzed in order to distinguish between the business solutions used by the airlines (PPs and HSs). Additionaly the influence of using codeshares and an alliances on the topology of the airline networks is investigated. This is performed by using complex network indicators to compare the seperate and combined (both codeshare and alliance) network layouts. The analysis confirms literature regarding FSCs, which turn out to use SFN associated with HS. LCCs however, are found not found to have RN associated with PP as suggested in literature, but a SFN with multiple interconnected hubs. The most important difference found between FSCs and LCCs is that LCCs tend to focus on diversity of destinations over frequency, whilst FSCs tend to focus on frequency over diversity. Combining networks into codeshare networks or the Skyteam alliance, increases the diversity of the network, the size and number of hubs and brings the behaviour closer to LCCs, however still with a focus on frequency over diversity. After this the synthetic static robustness of the seperate airline, codeshare and the Skyteam alliance networks is investigated in order to distinguish between the robustness behaviour of both FSCs and LCCs. The link between the complex network indicators and the synthetic static robustness of the ATN is also explored. This is performed by simulating error and attack on the separate airline networks and the codeshare and Skyteam alliance networks. Error is based on the random removal of airports from the network, while attack is based on the consecutive removal of nodes based on the heights of the degree, seat strength and (weighted) betweenness of the airports. The analysis confirms literature regarding FSCs, which shows low robustness against attack and high robustness against error. LCCs again show similar behaviour as the FSCs, contradicting literature, but confirming the results from Chapter 3. The shape of the curve of the cumulative degree distribution can be directly linked to the robustness independant of the size of the network. The higher the amount of hubs (with relative high degree), the higher robustness against attack. The robustness against error is much higher and similar for all networks. Combining networks into codeshare netrworks or the Skyteam alliance, will thus increase the robustness against attack. Finally the robustness analysis of ATNs is improved by introducing new methods of simulating more realistic error and attack scenarios. The link between the realistic robustness analysis and the synthetic robustness analysis is also investigated Three different phenomena are simulated: weather, strikes and volcano eruptions. Weather and volcano eruptions are simulated using the introduced geographic attack. Geographic attack is based on starting at an initiation airport and removing the other airports using geographic radial spreading. Strikes are simulated using the geographic degree, which groups the airport into FIR. The analysis puts the synthetic robustness in perspective. It shows that not only the number of hubs is important in order to improve the robustness of an ATN, but also the geographic spreading of the hubs.Air Transport and OperationsControl and OperationsAerospace Engineerin
[APD police officers from the Texas Lawman Magazine, 1964, page 2]
No full textPhotograph of a page taken from the 1964 Texas Lawman Magazine that shows photographs of Arlington police officers. Included is an article that discusses the promotion process and the names of those promoted to sergeants. Left to right and top to bottom are: Jess Gann, Ted Hamilton, Stan Hazlewood, B.J. Hlavaty, B.F. Honeycutt, Albert Kidd, Don Martin, Boyce Megason, Henry Morgan, Ron Morgan, H.H. Morris, Charles Patterson, Ray Ragland, Marrion Rettig, Don Ross, Ronald Shade, Pat Schuster, Earl Threadgill, Jerry Tucker, Jim Westfall, Bill Willard, Henry Alder, Roy Payne
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