21,641 research outputs found
PROLIFERATING CELL NUCLEAR ANTIGEN CYCLIN IN INCIDENTAL CARCINOMA OF THE PROSTATE
No full textMonoclonal antibody to proliferating cell nuclear antigen (PCNA) has been used to identify the growth fraction in ten cases of benign prostatic hyperplasia (BPH), in 20 prostatic microcarcinomas (PMC) and in 30 cases of infiltrating prostatic carcinoma (PC). Ten year follow-up was available on all cases by means of clinical, serological, radiological and echographic examinations. The percentage of PCNA-staining nuclei was independently counted by two observers. Statistical analysis showed significant differences between PCNA/cyclin score of BPH and PMC without recurrences with respect to those of PMC with progression and of PC. PCNA immunostaining may represent a reliable method for assessing cellular proliferative activity. It may be used as a more powerful diagnostic hallmark of PMC than patterns of non-malignant microglandular proliferation and is also a useful additional test for assigning histological grades to PMC and PC. Statistical analysis indicated that PCNA/cyclin index was an independent significant prognostic indicator of predicting malignant progression (P less-than-or-equal-to 0.01) and survival rates (P less-than-or-equal-to 0.05) of PC and PMC (> 5 mm diameter)
Effetti del GnRH sulla produzione di IL-6 in linfomonociti periferici nelle diverse fasi del ciclo
No full textHistological study on sinus lift grafting by Fisiograft and Bio-Oss
No full textThe work aims to provide a histological investigation of Fisiograft(R) a PLA/PGA copolymer, used as filler for bone defects in humans. The study was performed on biopsies of sinus lifts where Bio-Oss(R) and Fisiograft(R) gel were applied as graft material. Bone regeneration was satisfactory in all sinus lifts, even when Fisiograft(R) was applied alone. Due to remarkable osteoclast activity, Bio-Oss(R) granules were cleared from the majority of biopsy cores. At histology, Fisiograft(R) gel appeared as globes enveloped by fibroblasts, displaying an epithelial-like cell appearance. Due to its solubility in solvents, undegraded Fisiograft(R) (recorded for 7 months or more) did not stain whereas degraded Fisiograft(R) stained positive. The loose connective tissue, that surrounded Fisiograft(R), and bone contained isolated mastocytes. Bone grew inside the loose connective and often reached the surface of Fisiograft(R) by intervening cells. The results seem to indicate that Fisiograft(R) may be considered both a polymer useful for fastening bone substitutes inside a defect and in addition a material capable of prompting bone regeneration, with or without the use of a bone substitute. In addition to space-former and space-maintainer functions, Fisiograft(R) shows potential bone stimulation function, which may be labelled as osteopromotive capability
Rabbit bone behavior after orthodontic and pulsed low-frequency electromagnetic field treatments
No full textThe effect of low-frequency pulsed electromagnetic fields (PEMF) on bone was studied after an orthodontic treatment. A spring was positioned between the incisors and the first molar on both sides of the rabbit mandible for 14 days. A PEMF treatment was performed 6 h/day on the right side only. A greater distance between the first and the second molar was recorded in the PEMF treated side with respect to the left side. In addition, analysis of undecalcified sections shows a lower number and width of erosion cavities and a greater amount of newly formed (fluorescent) bone on the right side. In conclusion, PEMF treatment not only appears to increase bone formation, as previously reported in the literature, but, acting on osteoclast activity, also seems to improve bone quality during orthodontic treatment
Plasma gonadotropin releasing hormone and corticotropin releasing hormone levels in pathological pregnancies
No full textMELANOSIS (PIGMENTED MELANOCYTOSIS) OF THE PROSTATE GLAND.
No full textA case of stromal melanosis of the prostate gland is reported. Ultrastructurally, dendritic processes and melanosomes, but no basal lamina were observed in melanin-containing cells. In similar cases, characterized by the diffuse distribution of stromal pigmented melanocytes, the term "pigmented melanocytosis" rather than "blue naevus" appears more appropriate
Quantitative and qualitative AgNORs rates of prostate cancer on needle core biopsies: a multicentric study.
No full textFrom 1992 to 1993, the Scarpa Foundation Center of Pavia (SFCP) with 12 associated Italian Urological Units selected 40 cases of prostate diseases discovered on needle core biopsies, 5 of which were benign hyperplasias (BPH) in patients without clinical and morphological evidence of cancer and 35 prostate cancers (PRC) classified according to Gleason's histological grades (GLG) of PRC malignancy. Serum prostatic specific antigen (PSA) values were tested before clinical urological examination or biopsy or surgery. In all groups, AgNORs scores/nucleus were obtained by semi- and -automatic computerized image analysis and also by qualitative subjective counts of three observers on light microscopy. Our results pointed out a good correlation between PSA levels, GLG of PRC malignancy and AgNORs scores. The quantitative method showed an average number of AgNORS dots per nucleus between 2 and 3 in well differentiated PRC and higher than 3 in moderately differentiated and undifferentiated PRC, and exhibited more sensitivity over GLG3 than the qualitative investigation. The qualitative subjective count of AgNORs dots/nucleus seemed to be more reliable in differentiating the AgNORs scores of BPH (average of 1.81 dots/nucleus) from very well differentiated PRC with GLG1 + 2(average of 2.25 dots/nucleus) than quantitative analysis, which showed the same average value in both groups (2.11 dots/nucleus). For these reasons, also on needle biopsies of benign and malignant prostate diseases the subjective AgNORs count may aid the histological diagnostic judgement of malignancy, by avoiding misleading diagnoses of microscopic pictures of BPH cancer look likes and a predictive histologic malignant factor, in identifying PRC with low or high progression
Cluster headache and chronic paroxysmal hemicrania are characterized by different morphological aspects of nasal mucosa
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