1,720,987 research outputs found
A rapid synthesis of 2-alkynylindoles and 2-alkynylbenzofurans
No full textAn expeditious synthesis of 2-alkynylindoles and 2-alkynylbenzofuran derivatives has been devised
starting from easily available ortho-substituted aryl diynes
An Easy access to Unsymmetrically Substituted 4,4’-bi-1,2,3-Triazole
No full textA convenient synthesis of 4-alkynyl-1,2,3-triazoles and novel unsymmetrically substituted 4,40-bi-1,2,3-
triazole derivatives has been devised starting from easily available 1-trimethylsilyl-1,3-butadiyne. The
starting compound was reacted with several azides, leading to 4-(silylalkynyl)-1,2,3-triazoles, which
were easily transformed into 4-arylalkynyl-1,2,3-triazoles by a Pd catalyzed coupling reaction with aryl
halides, or into novel 4,40-bi-1,2,3-triazole derivatives by a subsequent cyclization reaction with azides
Synthesis of Symmetrical Ketones from Grignard Reagents and 1,1’-Carbonyldiimidazole
No full textcoupling reactions of 1,1'-carbonyldiimidazole with Grignard reagents provide a rapid and straightforward method for the synthesis of symmetrical ketones
A New Versatile Synthesis of Esters from Grignard Reagents and Chloroformates
No full textCross-coupling reactions of chloroformates with organocopper reagents, derived from Grignard reagents, cuprous bromide and lithium bromide, provide a rapid and straightforward method for the synthesis of esters
A straightforward synthesis of indole and benzofuran derivatives
No full textA new methodology for the synthesis of indole and benzofuran derivatives has been devised. The starting materials, ortho-substituted aryl
diynes, have been easily converted into new unsaturated bis-indolyl and bis-benzofuran derivatives and into 2-ethynylindole and 2-ethynylbenzofuran.
Both these products have been further elaborated into more complex unsaturated indole-benzofuran and bis-benzofuran derivatives
New Stereoselective Methodology for the Synthesis of Dihydroxerulin and Xerulin, Potent Inhibitors of the Biosynthesis of Cholesterol
No full textA new stereoselective methodology for the synthesis of both dihydroxerulin and xerulin has been devised. The key step required
cross-coupling reactions between the bromo trienyne, (1E,3E,5E)-1-bromo-8-trimethylsilyl-1,3,5-octatrien-7-yne and the appropriate
conjugated diynes. The palladium-catalyzed tandem cross-coupling/cyclization reaction of the resulting polyenynes with (Z)-3-iodo-2-
propenoic acid led directly to dihydroxerulin or xerulin with a high degree of stereoselectivity
Synthesis of Naturally Occurring Polyacetylenes via Bis-silylated Diyne
No full textA straightforward synthesis of a series of naturally occurring polyacetylenes has been developed, including the montiporynes A
and C, possessing cytotoxic activity against several human solid tumor cells, the atractylodin, with antibiotic activity against Escherichia coli,
and triynes, which display insecticidal activities, starting from the readily available 1,4-bis(trimethylsilyl)-1,3-butadiyne
Stereoselective Total Synthesis of (S)-Virol C and (S)-1-Dehydroxyvirol A
No full textA stereoselective total synthesis of (S)-Virol C and (S)-1-dehydroxyvirol A has been developed, based upon the selective and
sequential substitution of the two trimethylsilyl groups of readily available 1,4-bis(trimethylsilyl)-1,3-butadiyne
Synthesis of Polyacetylenic Montiporic Acids by means of Organosilicon Compounds
No full textA straightforward synthesis of polyacetylenic montiporic acids A and B has been developed, based upon the selective and sequential
substitution of the two trimethylsilyl groups of the readily available 1,4-bis(trimethylsilyl)-1,3-butadiyne
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