324,795 research outputs found
Living in Bible times : F.F. Bosworth and the Pentecostal pursuit of the supernatural.
No full textThis study examines American pentecostalism using the healing evangelist F.F. Bosworth as an interpretive lens. Bosworth's formative experiences, long-running success, and influence on pentecostal culture situate him as a representative leader. Yet his resistance to majority doctrine and lack of durable denominational ties challenges traditional definitions of pentecostalism, driving to the conclusion that pentecostal identity lies in the pursuit of the supernatural inherited from the nineteenth-century holiness movement rather than in doctrinal markers or connections to the Azusa Street revival. Bosworth's life story structures the dissertation, providing the most comprehensive biography of Bosworth to date. Experiences with Methodist revivalism, divine healing, and spirit-baptism reveal Bosworth as a typical pentecostal leader-in-the-making. Like numerous influential pentecostals, Bosworth had no significant connections to the Azusa Street revival. His early ministry and facilitation of a crucial revival in Dallas in 1912 established him as a leader in the young pentecostal movement, and his work with the Assemblies of God placed him in the mainstream who sought organizational stability for pentecostalism. In 1918, Bosworth publically rejected the tongues evidence doctrine, forcing his departure from the Assemblies of God. But his subsequent fame as a healing evangelist and the impact of his Christ the Healer (1924) demonstrate that he continued to represent and shape the supernaturalist impulse of pentecostalism. And while Bosworth's British-Israel teaching was widely disparaged by full gospel believers, this teaching was embraced by many influential early pentecostals. In his last decade, Bosworth became a major contributor to the post-World War II healing revival, shaping a new generation of independently-minded pentecostals in the same pursuit of the supernatural that had animated his entire career. Bosworth's thought centered on the continuity of God's activity, which helps explain his positions on tongues, divine healing, and biblical prophecy. While Bosworth popularized much of the thought of E.W. Kenyon, Bosworth also came to many of the same positions independently. As a unique living link between the late-nineteenth century divine healing movement and the postwar healing revival, as a leader who valued independence, and as an evangelist who focused on healing, Bosworth embodied the ethos of popular American pentecostalism
F.F. Bosworth: A historical analysis of his ministry development using social cognitive career theory
No full textThe purpose of this article was to discuss the findings related to research on the life history of Fred Francis Bosworth (1877�1958). This article explored his life story and critically analysed the influential factors that may have contributed to his success in the ministry. It seeks to answer the question: �How did Bosworth develop into a famous healing evangelist?� The historical case study method was used as the research design. It also employed a variant of Social Cognitive Career Theory (SCCT), which suggests that a person�s career choice can be determined by his or her self-efficacy beliefs, goals and expected outcomes. This article is the first to offer a critical analysis of Bosworth�s entire life and ministry and is also the first to use the concepts of SCCT to show how his adulthood success may have been influenced by the experiences of his childhood and youth. This article argued that several factors played a critical role in Bosworth�s development. Although Bosworth and others have attributed his success primarily to his Pentecostal experience, this study contends that his childhood, as well as secular and business experiences played a more important role than has been reported in the literature. Furthermore, this article showed that Bosworth�s path to success can be understood through the elements of SCCT. Through SCCT, one can see how Bosworth developed an interest in the healing ministry, how he chose to pursue the ministry as a career, and how he performed and set goals as an evangelist
Tracheal tissue regeneration
No full textTracheal circumferential defects involving more than half of the tracheal wall still represent an unsolved problem. Several studies have developed different methods to help repair cartilage and improve healing but a suitable tracheal reconstruction or replacement has not been achieved yet. Novel bioengineering technologies seem to be the new answer to this serious problem. This chapter briefly describes the fundamentals of the anatomical and physiological tracheal functions and provides a review of trachea tissue engineering. Then it describes the project and development by means of electrospinning of a biodegradable tubular tracheal scaffold with an in vitro and in vivo preliminary experimental approach
America's Financial Crisis: The End of an Era
No full textThis paper reviews research on the origins of the financial crisis of 2008–2009, highlights the key events that triggered a financial panic in September 2008, and summarizes the extraordinary policy actions the United States (US) has taken to ameliorate the crisis. We discuss the proximate causes of the crisis, including the characteristics and growth of the subprime mortgage market, and the distorted incentives and flawed regulatory structure surrounding the secondary market for mortgage-backed securities. We also assess the role of more fundamental macroeconomic determinants of the bubble in US asset prices, most notably low global interest rates attributed to either loose monetary policy or excess global saving. We find that while low global interest rates may have contributed to the boom in housing markets and speculative excesses, the poorly understood innovations and microeconomic distortions of the financial system played a more fundamental role. Finally, the otherwise extraordinary policy response of the US government has been limited by the lack of an effective restructuring of the financial system, and a recovery marked by higher private saving, weak domestic investment, and a large public deficit appears to be unsustainable. Ultimately, the US economy will need to shift about 3% of GDP from domestic consumption to the export sector. This will pose some serious challenges to countries that have come to rely on exports to the US market.global financial crisis; financial panic; american policy actions
Using electrospun scaffolds for tendon repair
No full textElectrospinning has become a popular technique in the field of biomaterials and tissue engineering as 3D structures can be easily created. With architectures similar to the extracellular matrix, electrospinning has been investigated for a wide range of tissues, including; bone, heart valves, trachea and tendons1.Being load-bearing tissues, tendons are susceptible to wear-and-tear and even spontaneous rupture, which then requires medical intervention. Autologous tendon tissue is used when a segmental repair or reconstruction is required. Whilst this repair is classed as the ‘gold standard’, it is not without several disadvantages – secondary sites of tissue morbidity are created which could prolong patient rehabilitation time and there is an increased risk of infection; and an adequate source of tendon tissue for autografting cannot be guaranteed. Therefore there remains an unmet clinical need and biomaterials are being investigated as a potential solution. A synthetic scaffold for tendon repair needs to incorporate the following factors in its design: (1) resemble the natural tissue structure, (2) be biocompatible and promote appropriate tissue healing, (3) provide sufficient mechanical strength to support new tissue formation and withstand applied forces, and (4) degrade at a rate which allows a smooth transfer of load without premature failure or accumulation of by-products.Poly(ε-caprolactone) (PCL) is a readily electrospinnable polymer and the alignment of emitted fibres can be controlled and further manipulated to create 3D yarn structures, which resemble the tertiary layer of the natural tendon hierarchy2. Material properties, such as tensile strength, can be tailored3 and the scaffolds are capable of supporting cell adhesion, proliferation and their orientation4,5. Implantation of scaffolds into the superficial digital flexor tendon of mice hind-paws yielded encouraging results with minimal inflammatory reaction and observation of cell infiltration into the scaffold and collagen deposition over a 12-month period.This research demonstrates the on-going development of electrospun scaffolds as a potential medical device for the treatment of tendon injuries.With special thanks to Dr Sarah Cartmell and Prof Sandra Downes for guidance and supervision, and acknowledgement of financial support from EPSRC, the UMIP Premier Fund, Regener8 and MRC-DPFS. References:1 ‘Electrospinning for Tissue Regeneration’, Edited by LA Bosworth and S Downes, Woodhead Publishing, Cambridge. 2011.2 ‘Tissue Repair Scaffold’, PCT/GB2009/002874, Inventors; S Downes and LA Bosworth. 3 Bosworth LA, ‘Electrospinning for tendon regeneration’, in Electrospinning for Tissue Regeneration, Woodhead Publishing, Cambridge. 2011;p148-167.4 Bosworth LA, Alam N, Wong JK, Downes S, ‘Investigation of 2D and 3D electrospun scaffolds intended for tendon repair’. Journal of Materials Science: Materials in Medicine. 2013; 24(6):1605-1614.5 Bosworth LA, Rathbone SR, Downes S, Cartmell SH, ‘Cyclical loading of electrospun scaffolds affects Mesenchymal stem cell response’. European Cells and Materials, Vol. 23. Suppl. 4, 2012 (page 1)
Using electrospun scaffolds for tendon repair
No full textElectrospinning has become a popular technique in the field of biomaterials and tissue engineering as 3D structures can be easily created. With architectures similar to the extracellular matrix, electrospinning has been investigated for a wide range of tissues, including; bone, heart valves, trachea and tendons1.Being load-bearing tissues, tendons are susceptible to wear-and-tear and even spontaneous rupture, which then requires medical intervention. Autologous tendon tissue is used when a segmental repair or reconstruction is required. Whilst this repair is classed as the ‘gold standard’, it is not without several disadvantages – secondary sites of tissue morbidity are created which could prolong patient rehabilitation time and there is an increased risk of infection; and an adequate source of tendon tissue for autografting cannot be guaranteed. Therefore there remains an unmet clinical need and biomaterials are being investigated as a potential solution. A synthetic scaffold for tendon repair needs to incorporate the following factors in its design: (1) resemble the natural tissue structure, (2) be biocompatible and promote appropriate tissue healing, (3) provide sufficient mechanical strength to support new tissue formation and withstand applied forces, and (4) degrade at a rate which allows a smooth transfer of load without premature failure or accumulation of by-products.Poly(ε-caprolactone) (PCL) is a readily electrospinnable polymer and the alignment of emitted fibres can be controlled and further manipulated to create 3D yarn structures, which resemble the tertiary layer of the natural tendon hierarchy2. Material properties, such as tensile strength, can be tailored3 and the scaffolds are capable of supporting cell adhesion, proliferation and their orientation4,5. Implantation of scaffolds into the superficial digital flexor tendon of mice hind-paws yielded encouraging results with minimal inflammatory reaction and observation of cell infiltration into the scaffold and collagen deposition over a 12-month period.This research demonstrates the on-going development of electrospun scaffolds as a potential medical device for the treatment of tendon injuries.With special thanks to Dr Sarah Cartmell and Prof Sandra Downes for guidance and supervision, and acknowledgement of financial support from EPSRC, the UMIP Premier Fund, Regener8 and MRC-DPFS. References:1 ‘Electrospinning for Tissue Regeneration’, Edited by LA Bosworth and S Downes, Woodhead Publishing, Cambridge. 2011.2 ‘Tissue Repair Scaffold’, PCT/GB2009/002874, Inventors; S Downes and LA Bosworth. 3 Bosworth LA, ‘Electrospinning for tendon regeneration’, in Electrospinning for Tissue Regeneration, Woodhead Publishing, Cambridge. 2011;p148-167.4 Bosworth LA, Alam N, Wong JK, Downes S, ‘Investigation of 2D and 3D electrospun scaffolds intended for tendon repair’. Journal of Materials Science: Materials in Medicine. 2013; 24(6):1605-1614.5 Bosworth LA, Rathbone SR, Downes S, Cartmell SH, ‘Cyclical loading of electrospun scaffolds affects Mesenchymal stem cell response’. European Cells and Materials, Vol. 23. Suppl. 4, 2012 (page 1)
Using electrospun scaffolds for tendon repair
No full textElectrospinning has become a popular technique in the field of biomaterials and tissue engineering as 3D structures can be easily created. With architectures similar to the extracellular matrix, electrospinning has been investigated for a wide range of tissues, including; bone, heart valves, trachea and tendons1.Being load-bearing tissues, tendons are susceptible to wear-and-tear and even spontaneous rupture, which then requires medical intervention. Autologous tendon tissue is used when a segmental repair or reconstruction is required. Whilst this repair is classed as the ‘gold standard’, it is not without several disadvantages – secondary sites of tissue morbidity are created which could prolong patient rehabilitation time and there is an increased risk of infection; and an adequate source of tendon tissue for autografting cannot be guaranteed. Therefore there remains an unmet clinical need and biomaterials are being investigated as a potential solution. A synthetic scaffold for tendon repair needs to incorporate the following factors in its design: (1) resemble the natural tissue structure, (2) be biocompatible and promote appropriate tissue healing, (3) provide sufficient mechanical strength to support new tissue formation and withstand applied forces, and (4) degrade at a rate which allows a smooth transfer of load without premature failure or accumulation of by-products.Poly(ε-caprolactone) (PCL) is a readily electrospinnable polymer and the alignment of emitted fibres can be controlled and further manipulated to create 3D yarn structures, which resemble the tertiary layer of the natural tendon hierarchy2. Material properties, such as tensile strength, can be tailored3 and the scaffolds are capable of supporting cell adhesion, proliferation and their orientation4,5. Implantation of scaffolds into the superficial digital flexor tendon of mice hind-paws yielded encouraging results with minimal inflammatory reaction and observation of cell infiltration into the scaffold and collagen deposition over a 12-month period.This research demonstrates the on-going development of electrospun scaffolds as a potential medical device for the treatment of tendon injuries.With special thanks to Dr Sarah Cartmell and Prof Sandra Downes for guidance and supervision, and acknowledgement of financial support from EPSRC, the UMIP Premier Fund, Regener8 and MRC-DPFS. References:1 ‘Electrospinning for Tissue Regeneration’, Edited by LA Bosworth and S Downes, Woodhead Publishing, Cambridge. 2011.2 ‘Tissue Repair Scaffold’, PCT/GB2009/002874, Inventors; S Downes and LA Bosworth. 3 Bosworth LA, ‘Electrospinning for tendon regeneration’, in Electrospinning for Tissue Regeneration, Woodhead Publishing, Cambridge. 2011;p148-167.4 Bosworth LA, Alam N, Wong JK, Downes S, ‘Investigation of 2D and 3D electrospun scaffolds intended for tendon repair’. Journal of Materials Science: Materials in Medicine. 2013; 24(6):1605-1614.5 Bosworth LA, Rathbone SR, Downes S, Cartmell SH, ‘Cyclical loading of electrospun scaffolds affects Mesenchymal stem cell response’. European Cells and Materials, Vol. 23. Suppl. 4, 2012 (page 1)
Did Aimee Semple McPherson Draw Bigger Crowds than F.F. Bosworth?
No full textCopyright (c) by Roscoe Barnes III#FFBosworth#AimeeSempleMcPhersonIn this blog post, Roscoe Barnes III reviews a mention of F.F. Bosworth and Charles S. Price in James William Opp's book, The Lord for the Body: Religion, Medicine, and Protestant Faith Healing in Canada, 1880-1930 (Mcgill-Queens University Press, 2007).</div
Can Damaged Tendons be Repaired using Electrospun Biopolymer Nanofibres?
No full textTitle: Can damaged tendons be repaired using electrospun biopolymer nanofibres? Author(s): Lucy A Bosworth, Sandra DownesAffiliation(s): School of Materials, University of Manchester, Grosvenor Street, Manchester, M1 7HS, UKAbstract:Tendon disease and injuries are caused by trauma, sport injuries and orthopaedic pathology. Current therapies are often ineffective with on-going pain, scarring and tissue degeneration. With no other synthetic, biodegradable tendon repair device available for clinical use, we have developed an electrospun 3D fibrous scaffold, with purposeful orientation, which mimics the tendon hierarchical tissue structure.Polycaprolactone (PCL) dissolved in acetone was electrospun using pre-determined parameters. Fibres were collected on a fine-edged mandrel rotating at high speed (aligned fibres) and low speed (random fibres). 3D fibrous bundles were fabricated by manipulating 2D mats of aligned fibres. Physicochemical characterisation of the three different scaffolds (2D aligned and random mats, and 3D bundles) was performed, including; tensile properties, fibre morphology and crystallinity. Cellular interactions of tendon cells seeded onto each scaffold were similarly determined by assessing; cell proliferation, contact guidance and matrix expression. Results determined 3D bundles to have superior tensile properties and, similar to aligned 2D mats, demonstrated cellular orientation comparable to cells within natural tendon. As a pilot study, 3D bundles were successfully implanted into the Achilles tendons??? of mice for three weeks. Normal ambulation returned within 48hrs and all mice survived. Research into longer-term in vivo studies and scaling of single 3D bundles to create hierarchical fibrous structures is currently on-going. We believe biodegradable 3D electrospun bundles, made from PCL, could provide an alternative therapy for the repair and regeneration of damaged tendons.Biographical statement:Lucy Bosworth is interested in electrospinning applications for tissue regeneration and in vitro models, and is currently continuing her PhD research, ???3D Electrospun Bundles of Polycaprolactone for Tendon Regeneration???, funded by a Proof of Principle grant. Lucy and Prof. Downes are co-editing an electrospinning book, titled; ???Electrospinning for Tissue Regeneration???
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