1,721,031 research outputs found
New insights into obesity and inflammation
No full textADIPOSE-TISSUE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; LEPTIN RESISTANCE; INTERRELATIONSHIPS; ADIPONECTIN; OVERWEIGHT; WOMEN; MIC
The consequences of aging on endocrine function of adipose tissue
No full textOnly very recently an increased interest rose in adipocytokines physiology and pathophysiology in geriatric medicine. However, the findings about leptin and adiponectin physiology and pathophysiology in the elderly as well as the relation between these adipocytokines and aging seem not always of univocal interpretation. This review will be focused on the physiology of leptin and adiponectin production in the elderly. Age-related changes in body composition, as well as the decline in function of different hormonal axes with aging, may alter the physiology of adipocytokines secretion in the elderly. The main mechanism regulating circulating leptin and adiponectin levels, even though in opposite ways, is represented by the amount of adipose tissue itself. Aging is associated with significant changes in body composition and in particular in absolute amount of body fat as well as in its distribution. It seems still not completely clear if aging may have an independent effect on leptin and adiponectin secretion itself from adipose tissue
[Regeneration of the pancreas in rats. Functional and morphological aspects after alloxan or ethionine administration and after partial resection]
No full text[Carbohydrate metabolism in gross obesity]
No full textResults obtained in an investigation of two groups of obese and grossly obese subjects are presented. Poorer carbohydrate tolerance was noted in the latter. Blood insulin patterns after oral glucose loading, however, were less easy to interpret. Overall, the values were much the same in the two groups. Nevertheless, analysis of the curves showed that the grossly obese displayed a later peak
Short- and long-term effects of hypocaloric diets containing proteins of different sources on plasma lipids and apoproteins of obese subjects
No full textThe influence of caloric restriction on lipid profile is controversial. This study was designed to evaluate the influence of dietary proteins from different sources on lipoprotein levels in obese subjects during a period of very low-caloric diet followed by 60 days of hypocaloric diet. The subjects were 24 obese patients aged 25-42 of at least 50% above ideal weight. The patients were separated into two groups and received for 15 days 375 kcal/day on the assumption that commercial textured preparations contained the same amount of proteins, respectively, as casein (group A) or soy protein (group B). Then the very low-caloric diet of the two groups was integrated with 425 kcal/day for 60 days. Body weight reduction was equivalent in the two groups. Total plasma cholesterol decreased significantly in both groups after the two periods of diet, but the percent variations were always significantly higher in the group B than in A. Total plasma triglycerides reduced significantly only in the group B. Very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) cholesterol behaved as total cholesterol in the two groups. High-density lipoprotein (HDL) cholesterol diminished significantly only after the 15 days of very low-caloric diet in group B, while it decreased throughout the diet in group A. The decrease of HDL cholesterol was mainly due to the HDL2 subfraction. The results of our study show that the substitution of soy protein for casein can be of benefit in those patients who need a long-term hypocaloric diet
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