1,721,028 research outputs found
Reversal of liver cirrhosis: a desirable clinical outcome and its pathogenic background.
No full textAbstract
Cirrhosis is the final stage of chronic liver damage of various etiologies. It used to be considered an irreversible lesion, but enormous advances in our understanding of hepatic cellular and molecular biology in the past 2 decades have challenged this view. There is now substantial evidence that cirrhosis can be a reversible process. This concept is supported by an increasing number of clinical reports showing the disappearance of cirrhotic lesions from liver biopsies taken from patients cured of their liver disease. The reversal of cirrhosis usually occurs in patients with short-lived liver disease, after the successful treatment of the underlying liver damage. Recently, however, we observed the spontaneous reversal of cirrhosis after the loss of hepatitis B viremia in 2 men, 21 and 28 years old, who had developed cirrhosis as young children. Several questions and controversial issues concerning the definition of advanced cirrhosis, the limitations of liver biopsy (eg, sampling, interpretation error), and the applicability of noninvasive methods to the assessment of fibrosis, are being addressed. Future prospects include the possibility of antifibrotic therapy to prevent fibrosis or favor its degradation
Viral Hepatitis: Treating hepatitis C in children: an open horizon.
No full textAbstract
Most children with chronic hepatitis C have minimal liver disease before adulthood, but could be at risk of progression to cirrhosis and hepatocellular carcinoma because of persistent virus replication. The results of the first controlled trial with PEG-IFN-α2a plus ribavirin are a step towards an appropriate treatment for these children
HIDDEN HEPATITIS B CORE ANTIGEN (HBcAg) IN SERUM IN HEPATITIS B VIRUS (HBV) INFECTION. RELATION TO LIVER DAMAGE
No full textLong-term outcome of hepatitis C in children
No full textI.F. = 9.503.
Categoria della rivista: ASTROENTEROLOGY & HEPATOLOGY
RECEPTORS FOR POLYMERIZED HUMAN SERUM ALBUMIN (pHSA) ON HEPATITIS B VIRUS (HBV) AND ANTI-RECEPTOR ANTIBODY IN HBV INFECTION
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