1,720,989 research outputs found
NANOSTRUCTURED LIPID CARRIERS (NLC) FOR POORLY-WATER SOLUBLE DRUGS: PREPARATION, CHARACTERISATION AND IN VITRO RELEASE STUDIES
No full textSOLID LIPID NANOPARTICLES (SLN) AS DRUG CARRIERS FOR NEUROPROTECTIVE AGENTS: PREPARATION, CHARACTERIZATION AND RELEASE STUDIES
No full textPREPARATION OF POLYMERIC NANOPARTICLES BY PHOTO-CROSSLINKING OF AN ACRYLOYLATED POLYASPARTAMIDE IN W/O MICROEMULSION
No full textBiodegradable polymeric nanoparticles have been prepared by UV irradiation of an acryloylated water soluble polymer by an inverse microemulsion. The starting polymer was a α,β‐poly(N‐2‐hydroxyethyl)‐D,L‐aspartamide (PHEA) partially functionalized with glycidyl methacrylate (GMA) in order to introduce reactive vinyl groups in the side chain. The PHEA‐GMA copolymer obtained (PHG) was crosslinked by UV irradiation of the inverse microemulsion prepared by mixing an aqueous solution of PHG with propylene carbonate (PC)/ethyl acetate (EtOAc) in the presence of sorbitan trioleate (SPAN 85) as surfactant. Nanoparticles obtained were characterized by FTIR spectrophotometry, transmission electron microscopy, size distribution analysis and zeta potential measurements. Nanoparticles investigated revealed spherical and homogeneous shading, the particle size having a mean diameter of 88 ± 13 nm (PDI = 0.21) and a negative surface charge in several aqueous media. Moreover, in vitro chemical and enzymatic hydrolysis studies evidenced the partial biodegradability of PHG nanoparticles, which is more evident after incubation with enzymes such as esterases. PHG nanoparticles were loaded during UV irradiation process with Cytarabine, chosen as a model drug, and Cyt‐loaded PHG nanoparticles were able to release it in a simulated physiological fluid (phosphate buffer at pH 7.4) and in blood plasma
VETTORI NANOPARTICELLARI LIPIDICI CONTENENTI RILUZOLO E COMPOSIZIONI FARMACEUTICHE CHE LI CONTENGONO
No full textIn vitro inhibition of staphylococcus aureus biofilms by solid lipid nanoparticles containing vancomycin
No full textNANOSTRUCTURED LIPID CARRIERS CONTAINING RILUZOLE AND PHARMACEUTICAL FORMULATIONS CONTAINING SAID PARTICLES
No full textThe present invention concerns the preparation, the physical-chemical, technological and pharmaceutical characterization of Riluzole-loaded nanoparticle vectors. The chosen production technology permitted to obtain these systems in a reproducible way, with high yields and low costs.
In particular, a novel formulation of Riluzole loaded into lipid nanoparticles was developed which is able to carry to the Central Nervous System a higher amount of drug in comparison with the free drug. In vivo results demonstrated that the administration on rats of these formulation permits to obtain a lower deposit of Riluzole in organs such as liver, spleen, heart and kidneys; the consequence is a reduction of side effects which actually are related with the administration of the free drug
POLYMERIC NANOPARTICLES OBTAINED BY PHOTOCROSSLINKING OF AN ACRYLOYLATED POLYASPARTAMIDE IN INVERSE EMULSION
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