1,721,120 research outputs found
Risultati preliminari sull'impiego in primavera di spirali vaginalicon progesterone nella bufala.
No full textThe overdetermined Cauchy problem in some classes of ultradifferentiable functions
No full textIn this paper we study the Cauchy problem for overdetermined systems of linear partial differential operators with constant coefficients in some spaces of ultradifferentiable functions of class (M_p ). We show that evolution is equivalent to the validity of a Phragmen-Lindeloef principle for entire and plurisubharmonic functions on some irreducible affine
algebraic varieties, and make applications in different situations. We find necessary and sufficient conditions for well posedness, and relate the hyperbolicity of a given system to that of its principal part
A proposito dei c.dd. divieti di vendita
No full textIl contributo, partendo dalle originali considerazioni di Mario Allara sui c.dd. divieti di vendere contenute nel volume del corso di diritto civile dedicato a «La vendita» del 1958, evidenza l’attualità del Suo pensiero come emerge dall’analisi critica della giurisprudenza nonché la modernità delle Sue riflessioni che anticipano gli orientamenti più attuali in tema di invalidità contrattuale
THE EFFECTS OF ALFAPROSTOL (PGF2a analogue) AND eCG ON REPRODUCTIVE PERFORMANCES IN POSTPARTUM RABBITS
No full text[EN] The aim of this study was to verify the effectiveness of post partum pharmacological oestrus synchronisation with alfaprostol or eCG in improving rabbit doe reproductive performances and to evaluate the incidence of pseudopregnancy in this species. One hundred and eighty commercial hybrid rabbit does, multiparous and lactating, were randomly divided into three groups (n=60) and treated on day 8 post partum (pp) as follows: Group A, 1 mL s.c. vitaminic solution with 200 mg alfaprostol, a synthetic analogue of PGF2a; Group B, 1 mL sc vitaminic solution with 20 I.U eCG; Group C (Control) 1 mL sc vitaminic solution. On day 11 pp (3 days after treatment), all the rabbits were artificially inseminated (AI), and injected with 0.8 mg of buserelin i.m. to induce ovulation. Concurrently, blood samples were taken for progesterone (P4) analysis by RIA with the following schedule: day 8 pp (before treatment), day 11 pp (before AI and the induction of ovulation) and day 16 pp (5 days after AI). Fertility was not influenced by hormonal treatments (71.7% and 71.2% respectively) compared to control (66.1%). Conversely, both PGF2a and eCG hormonal synchronisation treatments increased (P1 ng/mL). On day 5 after insemination 95.5% had P4 values, which attest to the presence of functional corpora lutea (CL) (P4>2 ng/mL). The results of this study show that as long as rabbitry is properly managed zootechnically and sanitarily, drugs such as alfaprostol and eCG, while not ameliorating fertility rate when used for post partum oestrus sychronisation, can increase litter size.Mollo, A.; Veronesi, M.; Battocchio, M.; Cairoli, F.; Brecchia, G.; Boiti, C. (2003). THE EFFECTS OF ALFAPROSTOL (PGF2a analogue) AND eCG ON REPRODUCTIVE PERFORMANCES IN POSTPARTUM RABBITS. World Rabbit Science. 11(2):63-74. https://doi.org/10.4995/wrs.2003.498SWORD637411
Metabolic adaptations in neonatal mother-deprived rabbits
No full textIn order to study the metabolic adaptation in response to 48 h transient doe-litter separation (DLS) in young rabbits (5 rabbits/d group) between postnatal 9 and 11 d, plasma concentrations of thyroid hormones T3 and T4, insulin, leptin, glucose, triglycerides (TG), and free fatty acids (FFA) were examined before (6-8 d), during (9-11 d), and after separation (12-16 d). T3 concentrations in newborn control rabbits gradually increased from 0.6 ng/mL at postnatal 6 d to 1.0 ng/mL at postnatal 16 d, whereas those of T4 remained fairly constant (25 ng/mL) up to postnatal 14 d, when T4 gradually declined to 8 ng/mL. T3 values of DLS newborn rabbits did not differ from those of controls at postnatal 10 and 11 d, but were lower (P<0.05) at postnatal 12 d, while T4 concentrations in DLS animals increased, although not significantly, between postnatal 10 and 12 d compared to controls. Insulin concentrations in young control rabbits ranged between 0.6 and 1.0 mg/L in the early postnatal days, whereas those for leptin averaged 2-3 ng/mL. Insulin and leptin values in DLS newborn rabbits were lower (P<0.05) at postnatal 10 and 11 d, but thereafter rebounded to levels close to those of controls. Glycaemia showed a comparable trend in both groups, ranging between 170 and 190 mg/dL up to postnatal 14 d, but thereafter decreased (P<0.05) to values of 120-130 mg/dL independently of treatment. Concentrations of TG varied greatly from day to day around a mean value of 300 mg/dL, whereas those of FFA remained at approximately the same steady-state levels from postnatal 6 to 16 d, averaging 0.8 mM without any significant differences between groups. In conclusion, these findings confirm that newborn rabbits can cope with the metabolic stress of starvation associated with DLS by lowering insulin and leptin concentrations while maintaining those of thyroid hormones, an overall endocrine response which, together with temporary increase of glucorticoids, successfully maintains an adequate energy balance
Immunopresence and enzymatic activity of nitric oxide synthases, cyclooxygenases and PGE2-9-ketoreductase and in vitro production of PGF2α, PGE2 and testosterone in the testis of adult and prepubertal alpaca (Lama pacos).
No full textThis study presents the first evidence for differences in COXs, PGE2-9-ketoreductase and NOSs immunopresence
and enzyme activity, and prostaglandin and testosterone production between the testes of adult
and prepubertal alpacas. The prepubertal testis immunohistochemical data revealed that COX1 was
expressed in spermatogonia and endothelial cells whereas COX2 was present only in the stromal cells.
In adult animals, COX2 immunosignals were evidenced in germ cells, as well as both COX1 and -2 in
Leydig and Sertoli cells. In adult testes, the spermatogonia, spermatocytes and round spermatids had
expression of e- and n-NOS only, whereas elongated spermatids exhibited immunopositivity for i- and
e-NOS and Sertoli cells expressed only n-NOS. In prepubertal alpacas, i-NOS was localized in spermatogonia,
e-NOS in Sertoli cells and all three NOS isoforms in Leydig cells. PGE2-9-ketoreductase immunopresence
was observed in spermatogonia nuclei and cytoplasm of prepubertal testis whereas they
were localized in spermatid acrosomal vesicle of adult. The enzymatic data indicated that COX1 activity
was higher than COX2 in adult alpaca testis whereas the activity of COX2 was greater than that of COX1
in prepubertal animals. Total NOS and PGE2-9-ketoreductase activities were more extensive in adult
alpacas. In vitro hormone production results showed that prepubertal testes released lower amounts of
testosterone and PGF2a while PGE2 synthesis was six times more elevated than in in vitro incubated
adult testes. Taken together, the data on COX2, i-NOS and PGE2 led us to hypothesize that development
in prepubertal male reproductive tissues utilizes a mechanism similar to that of inflammation
Prostaglandin receptors and role of G protein-activated pathways on corpora lutea of pseudopregnant rabbit in vitro
Full text linkStudies were conducted to characterize receptors for prostaglandin (PG) F(2alpha) (PGF(2alpha)) and PGE(2), and the signalling pathways regulating total nitric oxide synthase activity and progesterone production in rabbit corpora lutea (CL) of different luteal stages. CL were obtained at days 4, 9 and 13 of pseudopregnancy and cultured in vitro for 2 h with PGF(2alpha) or PGE(2) and with activators and inhibitors of G protein (Gp), phospholipase C (PLC), protein kinase C (PKC), adenylate cyclase (AC) and protein kinase A (PKA). High affinity PGF(2alpha) receptor (K(d)=1.9+/-0.6 nM mean+/-s.e.m. ) concentrations increased (P< or =0.01) four- to five-fold from early to mid- and late-luteal phases (50.6+/-8.5, 188.3+/-36.1 and 231.4+/-38.8 fmol/mg protein respectively). By contrast, PGE(2) receptor (K(d)=1.6+/-0.5 nM) concentrations decreased (P< or =0.01) from day 4 to day 9 and 13 (27.5+/-7.7, 12.4+/-2.4 and 16.5+/-3.0 fmol/mg protein respectively). The Gp-dependent AC/PKA pathway was triggered only on day 4 CL, mimicking the PGE(2) treatment and increasing progesterone production. In both day 9 and day 13 CL, the Gp-activated PLC/PKC pathway evoked a luteolytic effect similar to that induced by PGF(2alpha). The time-dependent selective resistance to PGF(2alpha) and PGE(2) by rabbit CL is mediated by factors other than a lack of luteal receptor-ligand interactions
Changes in refractoriness of rabbit corpora lutea to a prostaglandin F2 alpha analogue, alfaprostol, during pseudopregnancy
No full textThe responsiveness of rabbit corpus luteum to 200 micrograms of the prostaglandin F2 alpha (PGF2 alpha) analogue, alfaprostol, between Days 3 and 9 of pseudopregnancy was assessed by evaluating the decline in plasma progesterone after treatment with PGF2 alpha in 81 New Zealand White (NZW) rabbits. On Days 3-5, functional luteolysis was not observed. On Days 6, 7, and 8 of pseudopregnancy, the number of rabbits responsive to PGF2 alpha, rose from 38% to 71% and 83%, respectively. In the other cases, the effect of the PGF2 alpha analogue was transient as CL recovered in the following 2 or 3 days. By contrast, on Day 9 luteolysis was effective and persistent in all the animals. In rabbits treated on Day 9, progesterone decreased gradually from 10.6 +/- 0.7 within the first 6 h, but fell to 3.6 +/- 1.5 ng/mL (p < 0.01) 12 h after PGF2 alpha and to 0.2 +/- 0.1 ng/mL (p < 0.01) 24 h later
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