131 research outputs found
How an ill-conceived methodological approach can condemn the medical use of ozone therapy
No full textThe pioneer of the modern ozone therapy: Professor VELIO BOCCI
No full textThe sensibilities for the sick people and looking for the best available and less expensive
means to cure them, has been one constant features of the Italian Professor Velio Bocci,
to the point that most of his entire life has been devoted to helping those in need of
scientific medical assistance. In a similar way as his Siena ancestor countryman Giacomo
Sansedoni did. A picture of this prominent physician is at the walls of the Siena
Santa Maria della Scala Museum painted by the Siena Baroque painter Bernardino
Mei (XVII Century)
This physician of the XVII Century Giacomo Sansedoni decided to donate all his library
and important wealth to the Siena Santa Maria della Scala which was one of �the first
hospitals in Europe, with its own organization set up to care for pilgrims, assist the
poor and provide for abandoned children.� (1000 years of life)
NRF2 ACTIVATION AS TARGET TO IMPLEMENT THERAPEUTIC TREATMENTS
No full textA chronic increase of oxidative stress is typical of serious pathologies such as myocardial infarction, stroke, chronic limb ischemia, chronic obstructive pulmonary disease (COPD), type II-diabetes, age-related macular degeneration leads to an epic increase of morbidity and mortality in all countries of the world. The initial inflammation followed by an excessive release of reactive oxygen species (ROS) implies a diffused cellular injury that needs to be corrected by an inducible expression of the innate detoxifying and antioxidant system. The transcription factor Nrf2, when properly activated, is able to restore a redox homeostasis and possibly improve human health
Ozone acting on human blood yields a hormetic dose-response relationship
No full textAbstract The aim of this paper is to analyze why ozone can be medically useful when it dissolves in blood or in other biological fluids. In reviewing a number of clinical studies performed in Peripheral Arterial Diseases (PAD) during the last decades, it has been possible to confirm the long-held view that the inverted U-shaped curve, typical of the hormesis concept, is suitable to represent the therapeutic activity exerted by the so-called ozonated autohemotherapy. The quantitative and qualitative aspects of human blood ozonation have been also critically reviewed in regard to the biological, therapeutic and safety of ozone. It is hoped that this gas, although toxic for the pulmonary system during prolonged inhalation, will be soon recognized as a useful agent in oxidative-stress related diseases, joining other medical gases recently thought to be of therapeutic importance. Finally, the elucidation of the mechanisms of action of ozone as well as the obtained results in PAD may encourage clinical scientists to evaluate ozone therapy in vascular diseases in comparison to the current therapies.</p
The failure of HIV vaccines. A new autovaccine may overcome some problems
No full textThe hypothesis of an autovaccine for HIV is borne out by: (1) the present lack of a valid vaccine; (2) by a remarkable improvement of the HAART, which however does not prevent HIV mutagenicity and a consequent valid immunological response and (3) the persistence of a hidden infection ready to thrive again. The preparation of the autovaccine is described as well as the administration schedule but only a clinical study will define its validity. © 2009 Elsevier Ltd. All rights reserved
A realistic evaluation of the action of ozone on whole human blood
No full textWe have clarified the role of the ozone concentration in relation to the resistance of human erythrocytes in whole human blood or in blood diluted
either in saline or in distilled water.
Spectrophotometric data related to haemoglobin were evaluated by exposing samples of fresh human blood directly to ozone doses (ratio 1:1
volume), within the therapeutic range (0.21–1.68 mM) and to one toxic dose (3.36 mM). Furthermore, the same determinations have been carried
out after previous dilution of the same blood with either pure water or physiological saline (1 ml blood + 29ml diluent) followed by ozonation
with the above reported ozone doses. Addition of either saline or water implies a dilution of plasma antioxidants and also total haemolysis after
water dilution. Particularly the latter case represents a most unphysiological situation because the osmotic shock causes the solubilization of the
erythrocytic content. While it is possible to demonstrate that after haemolysis there is an ozone-concentration dependent transformation of some
oxyhaemoglobin to methaemoglobin, no such process occurs after ozonation of whole blood.
The results of this study fully confirm our previous data that judicious ozone doses neither damage erythrocytes, nor induce oxidation of
intracellular haemoglobin. We hope that our conclusions will definitively clarify the absence of toxicity of ozonetherapy
Important details to be clarified about the effect of rectal ozone on the portal vein oxygenation
No full text
Randomised, double-blinded, placebo-controlled, clinical trial of ozone therapy as treatment of sudden sensorineural hearing loss
No full textLetter to the Edito
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