38 research outputs found
Sudeten German history
No full textTitle: Sudetendeutsche Geschichte (Sudeten German history) Originally published: Reichenberg (Cz. Liberec), Sudetendeutscher Verlag Franz Kraus, 1935 Language: German The excerpts used are from Sudetendeutsche Geschichte (Reichenberg: Sudetendeutscher Verlag Franz Kraus, 1937), pp. 9–20. About the author Josef Pfitzner [1901 Petersburg near Zuckmantel (Cz. Petrovice near Zlaté Hory, Austrian Silesia) – 1945, Prague]: Bohemian German historian and politician. He was born into a shoemaker’s fam..
Three Eichendorff lieder of Hans Pfitzner : study of musical and poetic affinity
No full text"Joseph von Eichendorff relied upon the sounds of words to create a poetic atmosphere; this is metaphorical rather than literal. Hans Pfitzner rarely used overt text-painting (madrigalism), yet created highly evocative music. This, like the poetry of Eichendorff, is metaphorical interpretation rather than literal depiction; therefore, Pfitzner's Eichendorff settings lend compound illumination to the poetry. "Three Eichendorff Lieder of Hans Pfitzner: A Study of Poetic and Musical Affinity" explores three such settings. This project is limited to the examination of Pfitzner's setting of three Eichendorff poems: "Der Versp tete Wanderer," "Das Alter," and "In Danzig." To the best of the author's knowledge, each of these poems has received only one other musical setting. Analysis of the music and poetry will be for the purpose of demonstrating the affinity of Pfitzner's and Eichendorff's compositional aims, rather than to formal theoretical ends. Eichendorff's general stylistic traits will be noted, though extensive poetic analysis will be limited to the three poems at hand. Likewise, Pfitzner's general compositional traits will be set forth, and in-depth analysis will be reserved for the three Lieder topical to this study. Drawing on information gathered from examination of the poetry and Pfitzner's settings thereof, the present study will relate the compositional goals of Eichendorff and Pfitzner to show an affinity between composer and poet. Eichendorff's poetic intentions as interpreted by Pfitzner's music will be elucidated."--Abstract from author supplied metadata
Abstract P5-07-02: Systematic analysis and modulation of Ki67 interobserver variance in 9069 patients from three clinical trials – How much pathologist concordance is needed for meaningful biomarker results?
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Hans Pfitzner's conception of musical drama
No full textAls Opernkomponist und Verfasser umfangreicher opernästhetischer Schriften ist Hans Pfitzner heutzutage nahezu vergessen. Obwohl die Opernbühne in der Biographie Hans Pfitzners eindeutig das Zentrum seines Wirkens bildet, wurde der Opernkomponist in der neueren musikwissenschaftlichen Literatur, die sich nicht einseitig dem Nachweis einer politisch wie musikalisch-ästhetischen reaktionären Ideologie in seinem Denken verschrieben hat, bislang nur wenig berücksichtigt. In seinen Bühnenwerken und operntheoretischen Schriften spiegelt sich jedoch eine intensive Auseinandersetzung mit dem Wagnerschen Erbe. In seinen Schriften zur Operndichtung bezieht sich Pfitzner explizit auf Wagner, dessen Idee des Musikdramas er zum Ausgangspunkt für seine eigenen Reflexionen nimmt. Die vorliegende Untersuchung macht es sich zur Aufgabe, anhand der opernästhetischen Schriften Pfitzners eigener Konzeption des musikalischen Dramas nachzugehen. Die Untersuchung der operntheoretischen Schriften zeigt deutlich, daß der Gegensatz von Inspiration und Reflexion den Dreh- und Angelpunkt in Pfitzners Opernästhetik bildet.Today, as a composer of operas and author of voluminous writings about the aesthetics of operas, Hans Pfitzner is nearly completely fallen in oblivion. Although the opera stage formed the center of his biography and his artistic work, the recent musicological literature do not really take in consideration Hans Pfitzner as a composer and theoretician of operas. His works for musical theatre and his theoretical writings reflect Pfitzner’s analysis of the artistic heritage of Richard Wagner. The analytical study on hand explores on the basis of Pfitzner’s theoretical writings his own idea of musical drama. It shows that the opposition of inspiration and reflection is the pivotal point in Pfitzner’s aesthetics of musical drama
Flamelet Combustion Modeling and Detached Eddy Simulation of a Rocket Model Combustor with Capacitive Heating
No full textThe Steady Laminar Flamelet Combustion Model was used in combination with the Improved Delayed Detached Eddy turbulence model. A model rocket combustor was simulated with these models. Combustion was performed with gaseous methane and oxygen, injected non-premixed. Experimental data was available for the pressure and wal heat flux to validate the simulation model.Aerospace Engineerin
C*-algebras have a quantitative version of Pełczyński's property (V)
No full textsummary:A Banach space has Pełczyński's property (V) if for every Banach space every unconditionally converging operator is weakly compact. H. Pfitzner proved that -algebras have Pełczyński's property (V). In the preprint (Krulišová, (2015)) the author explores possible quantifications of the property (V) and shows that spaces for a compact Hausdorff space enjoy a quantitative version of the property (V). In this paper we generalize this result by quantifying Pfitzner's theorem. Moreover, we prove that in dual Banach spaces a quantitative version of the property (V) implies a quantitative version of the Grothendieck property
Joseph Goebbels at the ND
No full textThe segment from the 1940 Český zvukový týdeník Aktualita (Czech Aktualita Sound Newsreel) No. 47 reports on the visit of Reich Minister Joseph Goebbels to Prague on 5 November 1940. At the station, he is greeted by Secretary of State of the Reich Protectorate Karl Hermann Frank, Konrad Henlein, Curt Ludwig Ehrenreich Burgsdorf and Colonel Arthur von Briessen. After a parade of the SS guard of honour, Joseph Goebbels leaves by car for Prague Castle. After being greeted at the Matthias Gate (Matyášova brána), he visits the Czernin Palace (Černínský palác) in the company of Reich Protector Konstantin von Neurath and Karl Hermann Frank, and gives a speech to the gathered cultural workers. This is followed by a Nazi party celebration in the hall of the Industrial Palace at Výstaviště, a visit to the grounds of Prague Castle and other important sights in the capital. Following that is a meeting between Goebbels, Prague Mayor Alois Říha, his deputy Josef Pfitzner and the head of state Emil Hácha. Goebbels, accompanied by president Hácha, visits the National Theatre to see a newly put on production of Prodaná nevěsta (The Bartered Bride). At the theatre he meets Karel Herman Frank, conductor Václav Talich and the director of the National Theatre, Karel Neumann
Week of Czech Youth
No full textSegment from Český zvukový týdeník Aktualita (Czech Aktualita Sound Newsreel) issue no. 29A from 1944 was shot during the Week of Czech Youth event organised by the Board of Trustees for the Education of Youth and held from 1 to 9 July. The programme included a concert held on Old Town Square on 8 July. The orchestra and choir consisted of several hundred young musicians and singers. Minister of Education and People´s Enlightenment and Chairman of the Board Emanuel Moravec and Deputy Mayor Joseph Pfitzner watched the event from the balcony of the Old Town Hall. The Board of Trustees´ youth set out from the square in a parade through the streets of Prague. The following day, a sports afternoon took place at Strahov Stadium. Guests of honour included Prime Minister Jaroslav Krejčí and the General Secretary of the Board František Teuner. Emanuel Moravec spoke to the participants. The programme included women´s floor exercises, track and field races and women in stylised costumes dancing to folk songs. The event was concluded with the athletes and audience paying homage to Adolf Hitler
Abstract P1-07-01: HLA class I expression is associated with tumor-infiltrating lymphocytes and response and survival after neoadjuvant chemotherapy in hormone receptor-positive, HER2-negative breast cancer
No full textAbstract
Background: Interactions between cancer cells and the host immune system influence tumor biology, response to therapy and patient survival and their modulation offers promising new approaches for cancer therapy. The downregulation or loss of HLA class I expression in breast cancer cells might be an effective mechanism to evade the recognition by the immune system facilitating malignant behavior.
Aim: To evaluate the association of tumor-infiltrating lymphocytes (TILs) with HLA class I expression and its theranostic value for therapy response and survival after neoadjuvant chemotherapy.
Methods: HLA class I expression was evaluated by immunohistochemistry in a cohort of 732 pre-therapeutic core biopsies from breast cancer patients treated within the neoadjuvant GeparTrio trial. Patients received anthracycline- and taxane-based neoadjuvant therapy and adjuvant endocrine treatment if hormone receptor-positive (HR+). A publicly available microarray dataset of pre-therapeutic core biopsies from 508 breast cancer patients that received neoadjuvant chemotherapy and endocrine treatment if HR+ was used for validation of the results. The association of HLA class I expression with predefined genomic signatures for immune cell populations was evaluated in publicly available data from the cancer genome atlas.
Results: HLA class I expression was associated with TILs (p < 0.001) and was predictive of better response to neoadjuvant chemotherapy in the subgroup of patients with HR+/HER2- breast cancer (14 % in tumors with high HLA vs. 7 % in tumors with low HLA, p = 0.029). Interestingly, high HLA was also predictive for shorter progression-free survival in univariate analysis (HR 1.590, 95 % CI 1.062—2.380; p = 0.024) and after adjustment to clinical and pathological parameters (HR 1.701, 95 % CI 1.105—2.618; p = 0.016). The results could be validated in the independent microarray-based dataset (HR 1.521, 95% CI 1.088 – 2.129; p = 0.0142). HLA class I was not associated with therapy response or survival in hormone receptor-negative breast cancer. HLA class I was associated with a predefined signature for T-cells and cytotoxic T- cells in the cancer genome atlas dataset (rho = 0.546).
Conclusion: HLA class I expression is associated with better response but shorter progression-free survival in HR+/HER2- breast cancer following neoadjuvant chemotherapy. The underlying mechanisms warrant further investigation.
Citation Format: Sinn BV, Weber K, Denkert C, Fasching PA, Schmitt WD, Thomas K, Ingold-Heppner B, van Mackelenbergh M, Symmans WF, Marmé F, Taube E, Müller V, Kunze CA, Schem C, Pfitzner BM, Stickeler E, von Minckwitz G, Loibl S. HLA class I expression is associated with tumor-infiltrating lymphocytes and response and survival after neoadjuvant chemotherapy in hormone receptor-positive, HER2-negative breast cancer [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P1-07-01.</jats:p
