1,720,996 research outputs found
The metanalysis of antiplatelet treatment trials. A proposal of an additional key of lecture [La metanalisi dei trial di terapia antiaggregante. Proposta di una chiave aggiuntiva di lettura]
No full textThe efficacy of drug treatment is conventionally assessed by clinical trials. In these studies, experimental design, data analysis and interpretation of results are based on statistical methods. It is difficult to relate to a specific patient the data obtained from statistically analysed studies of population. In our opinion the statistical parameter NNT (Number of patients Needed to Treat) indicates the effectiveness of a treatment taking into consideration the basal risk as well as the risk reduction after therapy. We applied the NNT parameter to data taken from the metanalysis Antiplatelet Trialists' Collaboration concerning secondary prevention of adverse vascular events with antiplatelet drugs. We focused on the long-term effect of antiplatelet therapy on the adverse events reduction; in the first year of treatment we observed a NNT value of 37, in the second year a NNT value of 59 and in the third year a NNT value of 200; in the fourth year we found absence of effect. The NNT parameter allows us to evaluate immediately the economic consequences of therapeutic strategies and the clinical impact of a long-term treatment
Variazioni diurne dell'effetto anticoagulante in corso di infusione continua e.v. di eparina non frazionata nell'uomo.Modificazioni indotte da acido acetilsalicilico per os.
No full textNew trends in docimology. Multiple-choice test using automated procedures [Nuove acquisizioni di docimologia. L'utilizzo di test a scelta multipla mediante una procedura automatizzata]
No full textTrazodone Contramid® in clinical practice: personalizing antidepressant intervention
No full textThis paper examines the use of Trazodone Contramid® in major depressive disorder (MDD), with a focus on practical guidance regarding real world challenges. The paper includes clinical case reports, developed for didactic reasons, which detail the practical management with Trazodone Contramid® of patients with MDD and either insomnia or anxiety or dementia or isolated (ipo)manic symptoms, which often fulfill the criteria for a diagnosis of MDD with with anxious distress or MDD with mixed features, according to the new DSM-5 classification
Comparison of time – frequency distribution techniques applied to a simulated carotid doppler signal
No full textCosts determination in hospital enterprises. Administrative costs and operating aspects [La determinazione dei costi nelle aziende ospedaliere. Valenze gestionali ed aspetti operativi]
No full textIncrease of adenosine plasma levels after trimetazidine administration. A pharmacological preconditioning?
No full textEffect of iloprost on plasma levels of serotonin and asymmetrical dimethylarginine, and on platelet levels of serotonin in patients affected by peripheral arterial occlusive disease
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Plasma and platelet serotonin levels as a predictor of fluoxetine response in depressed patients
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