1,720,976 research outputs found
LA LDL aferesi, tecniche e potenzialità terapeutiche" LE IPERCOLESTEROLEMIE. I Quaderni del CNR
No full textBehaviour of Lp(a) and apoproteins (A1,b,C2,C3,E) during and after theraphy with sinvastatin
No full textThe efficacy of simvastatin in reducing plasma cholesterol is well documented. Other molecules within the apo lipoprotein family, particularly lipoprotein.(a) Lp(a), have recently been found to have a predictive and/or causative role in atherosclerosis. Based on these considerations, we studied 15 patients affected by primary hypercholesterolemia to evaluate the effect of simvastatin in Lp(a) and apoprotein plasma levels (A1, B, C2, C3, E), in addition to the classic lipid parameters. Clinical and laboratory parameters were evaluated before therapy, after 12 weeks of therapy, and after 5 weeks of drug withdrawal. Simvastatin therapy produced a significant reduction in total cholesterol (CH) and LDL-CH (p < 0.0001), and a significant increase in HDL-CH (p < 0.01); no variation was observed in triglyceride (TG) levels. Simvastatin therapy further showed a significant decrease in apoC2 (p < 0.05), the apo C2/C3 ratio (p < 0.01), and apoE (p < 0.01), as well as a significant increase in Lp(a) plasma levels (p < 0.05). All of the parameters studied returned to pretreatment values 5 weeks after drug withdrawal; only HDL-CH persisted above the values reached during therapy. Our data agree with those documenting the beneficial effect of simvastatin in greatly decreasing CH and LDL-CH, but point out the need for further studies on the long-term effect of simvastatin on apoprotein molecules, such as on Lp(a), in order to fully establish its role in the secondary prevention of atherosclerosis
Analysis of renal immune-deposits in canine leishmaniasis. Preliminary results.
No full textPrevious studies carried out on 34 dogs spontaneously infected by Leishmania infantum showed the presence of kidney lesions characterized by immunologically mediated glomerular and tubular damage. Glomerular immune-deposits were studied in 13 of these dogs. Immunoglobulins were isolated from kidney tissues by acid elution; IgG fractions from eluates, obtained by ammonium sulfate precipitation, were subjected to clonotypic analysis by autoradiography after isoelectrofocusing (IEF) using 125I radiolabelled goat IgG fraction-anti Fab2 of dog IgG. Idiotypic characterization of IgG eluted from kidney tissues was performed by IEF and autoradiography using both 125I radiolabelled membrane antigens of L. infantum extracted by Triton x 100 and 125I radiolabelled dog IgG for rheumatoid or anti-idiotypic activity. The IgG deposited in the kidney tissues of examined dogs were polyclonal and a specific activity against Leishmania membrane antigens was revealed. Meanwhile an anti-IgG activity of deposited immunoglobulins was not observed. Z9 1
Etiopathogenesis of glomerulonephritis in canine leishmaniosis: idiotypic characterization of IgG eluted from the kidney tissue
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Renal involvment in canine leishmaniosis. A Light, immunohistochemical and ultrastructural study
No full textPlasma cholesterol regulates soluble cell adhesion molecules expression in familial hypercolesterolemia
No full textClinicopathological Study of Renal Involvment in Dogs Infected by Leishmania infantum: an Attempt to Characterize the Immunopathogenesis of Glomerular Lesions
No full textStudies on the pathogenesis of glomerulonephritis in dogs infected by Leishmania infantum. Characterization of circulating immune complexes and immunoglobulins eluted from kidney tissues
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