1,721,105 research outputs found
In vitro activities of three semisynthetic amide derivatives of teicoplanin, MDL 62208, MDL 62211, and MDL 62873.
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Adhesiveness of Bacteroides fragilis strains isolated from faeces of healthy donors, abscesses, and blood.
No full textResistenza spontanea in vitro agli antibiotici glicopeptidici in diverse specie stafilococciche.
No full textIn vitro activities of ramoplanin and four glycopeptide antibiotics against clinical isolates od Clostridium difficile
No full textSeventy strains of Clostridium difficile, all isolated from symptomatic patients, were found to be uniformly susceptible to ramoplanin, a new glycolipodepsipeptide antibiotic, and to four glycopeptides (vancomycin, teicoplanin, and two semisynthetic teicoplanin derivatives). Ramoplanin is recommended for further evaluation in the treatment of C. difficile-associated disease
Cloning and expression of the Staphylococcus aureus glucosaminidase in Escherichia coli.
No full textA fragment of Staphylococcus aureus DNA encoding the glucosaminidase determinant was cloned in Escherichia coli by inserting the Sau3A genomic fragments in the BamHI site of the plasmid vector pBR322. One clone selected on the basis of its lytic activity was shown to contain a hybrid plasmid (pEU213) carrying a 4.7 kb insert of S. aureus DNA. Lytic activity was tested using different assays, and the enzyme production was confirmed by immunological reactions. An appreciable reduction of lytic activity was noted after few subcultures. The E. coli carrying pEU213 had a slower growth rate and increased autolytic activity compared to the parental strain. The possible reasons for this behavior are discussed
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