323,084 research outputs found
MODELLO SEMPLIFICATO PER LA DESCRIZIONE DEL COMPORTAMENTO DI UN MATERIALE IGROSCOPICO UTILIZZATO PER IL CONTROLLO IGROMETRICO DI PICCOLI AMBIENTI
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Code to Code Comparison of Aircraft-Mode Tilt-Rotor Aerodynamics
No full textA global comparison of several blind-test numerical predictions of the aerodynamic field around the
Erica model in aircraft mode, carried out by some Partners of the NICETRIP consortium, is presented.
The calculations are carried out with different codes, different turbulence models, different wind tunnel
setups and different grids, with the objective of supporting the future experimental test campaign in
the DNW-LLF and ONERA S1Ma wind tunnels. It is found that the level of unsteadiness introduced
by the rotor wake on the aerodynamic loads on the fuselage, wing and nacelle may be relevant. The
influence of the lower-mounted wind tunnel support is rather limited, while the rear-mounted support
introduces some local unsteady effects on the fuselage loads. The overall qualitative agreement of the
pressure distributions among different calculations is acceptable, while the scatter of the quantitative
average loads is somewhat important
Sperimentazioni su un prototipo di vetrina museale corredato di un sistema passivo per il controllo igrometrico
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Fyn Kinase in Brain Diseases and Cancer: The Search for Inhibitors
No full textFyn is a non-receptor tyrosine kinase belonging to the Src family kinases. It has been shown to play important roles in neuronal functions, including myelination and oligodendrocytes formation, and in inflammatory processes. It has also demonstrated its involvement in signaling pathways that lead to severe brain pathologies, such as Alzheimer's and Parkinson's diseases. Moreover, Fyn is upregulated in some malignancies. Experimental studies demonstrated that Fyn inhibition could be useful in the disruption of metabolic processes involved in cancer and in neurodegenerative diseases. Unfortunately no specific Fyn inhibitor has been discovered so far, being the reported compounds active also on other members of Src family or on different tyrosine kinases. However, multitargeted inhibitors might be endowed with therapeutic potential. Indeed, as increasingly reported, also a not completely selective inhibitor of a specific protein could be therapeutically useful, affecting a number of cell pathways involved especially in cancer development. In this review, we report some examples of small molecule tyrosine kinase inhibitors for which data on Fyn inhibition, both in enzymatic and in cell assays, have been reported, with the aim of giving information as starting point for the researchers working in this field
Sar analysis of small molecules interfering with energy-metabolism in mycobacterium tuberculosis
No full textTuberculosis remains the world’s top infectious killer: it caused a total of 1.5 million deaths and 10 million people fell ill with TB in 2018. Thanks to TB diagnosis and treatment, mortality has been falling in recent years, with an estimated 58 million saved lives between 2000 and 2018. However, the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb strains is a major concern that might reverse this progress. Therefore, the development of new drugs acting upon novel mechanisms of action is a high priority in the global health agenda. With the approval of bedaquiline, which targets mycobacterial energy production, and delamanid, which targets cell wall synthesis and energy production, the energy-metabolism in Mtb has received much attention in the last decade as a potential target to investigate and develop new antimycobacterial drugs. In this review, we describe potent anti-mycobacterial agents targeting the energy-metabolism at different steps with a special focus on structure-activity relationship (SAR) studies of the most advanced compound classes
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