1,721,034 research outputs found
Upwardly mobile proteins. The role of HMG proteins in chromatin structure, gene expression and neoplasia
No full text
The evolution of High Mobility Group Box (HMGB) chromatin proteins in multicellular animals
No full textSeveral nuclear events during apoptosis depend on caspase-3 activation but do not constitute a common pathway
No full textHMG proteins: dynamic players in gene regulation and differentiation
No full textCore histones package the genome into nucleosomes andcontrol its accessibility to transcription factors. High mobilitygroup proteins (HMGs) are, after histones, the second mostabundant chromatin proteins and exert global genomicfunctions in establishing active or inactive chromatin domains.It is becoming increasingly clear that they also specificallycontrol the expression of a limited number of genes. Moreover,they contribute to the fine tuning of transcription in response torapid environmental changes. They do so by interacting withnucleosomes, transcription factors, nucleosome-remodellingmachines, and with histone H1
A simple model of NF-kappaB dynamics reproduces experimental observations
No full textThe mathematical modeling of the NF-κB oscillations has attracted considerable attention in recent times, but there is a lack of simple models in the literature that can capture the main features of the dynamics of this important transcription factor. For this reason we propose a simple model that summarizes the key steps of the NF-κB pathway. We show that the resulting 5-dimensional dynamical system can reproduce different phenomena observed in experiments. Our model can display smooth and spiky oscillations in the amount of nuclear NF-κB and can reproduce the variety of dynamics observed when different stimulations such as TNF-α and LPS are used. Furthermore we show that the model can be easily extended to reproduce the expression of early, intermediate and late genes upon stimulation. As a final example we show that our simple model can mimic the different transcriptional outputs observed when cells are treated with two different drugs leading to nuclear localization of NF-κB: Leptomycin B and Cycloheximide
- …
