1,721,076 research outputs found
Overexpression of ubiquitin downregulates transcription of the endogenous UbC gene in HeLa cells
No full text32nd FEBS Congressw, MOLECULAR MACHINE
Increased glucose metabolism by enzyme-loaded erythrocytes in vitro and in vivo normalization of hyperglycemia in diabetic mice
No full textINCREASED GLUCOSE CONSUMPTION BY HUMAN AND MICE ERYTHROCYTES OVERLOADED WITH HEXOKINASE AND GLUCOSE OXIDASE.
No full textUbiquitin over-expression promotes E6AP degradation and reactivation of the p53/mdm-2 pathway
No full text32nd FEBS Congress, Molecular Machine
The ubiquitin-dependent proteolytic system and other potential targets for the modulation of nuclear factor-kB (NF-kB)
No full textCURRENT DRUG TARGET
Human red blood cell loading with hexokinase-inactivating antibodies. An in vitro model for enzyme deficiencies
No full textUbiquitin C gene: Structure, function, and transcriptional regulation
No full textUbiquitin C (UbC) is one of the four genes encoding for ubiquitin in the mammalian genome. It has been described as the most responsive gene to cellular treats such as UV irradiation, heat shock, oxidative stress and translational impairment; it was also re- ported to contribute to maintaining ubiquitin steady state levels under physiological conditions. Despite the bulk of knowledge concerning its function, little is known about the molecular mechanisms modulating UbC expression. Here we review the state of the art of UbC structure, function and transcriptional regula- tion. Starting from the first evidences which circum- scribed the genomic region, pointing out both basic promoter marks (such as transcription start site and TATA-like element), and transcript structure (exon- intron boundaries) we go through more detailed mo- lecular studies performed by Marinovic in 2002 and by Bianchi et al. in 2009 and 2013. Herein, the key players orchestrating UbC gene basal activity are underlined
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