1,721,142 research outputs found
Retinoids in the chemoprevention of non-melanoma skin cancers: Why, when and how
No full textINTRODUCTION:
The chemoprevention refers to the use of various types of chemical agents for preventing carcinogenic progression. Systemic retinoids are the most studied chemopreventive agents due to their capacity to regulate cell proliferation and their demonstrated efficacy in several clinical studies.
OBJECTIVES:
The aim of the authors was to give precise indications regarding the use of the systemic retinoid in the chemoprevention of non-melanoma skin cancer (NMSC).
METHODS:
The authors reviewed the literature found through a search to MEDLINE (from 2001 to December 2011).
RESULTS:
Both acitretin and isotretinoin are effective for the prevention of NMSC. Isotretinoin is preferred in xeroderma pigmentosum and nevoid basal cell carcinoma syndrome, whereas acitretin is more used in transplant recipients, psoriasis and severe sun damage.
CONCLUSION:
Despite numerous studies of the literature concerning retinoids in chemoprevention of NMSC, precise details of the type of retinoid to use, dosage and the duration of this preventive treatment and how to manage side effects in the case of long-lasting treatment are still not uniform and comparable. Moreover, neither guidelines nor approval by Food and Drug Administration exist to regulate the use of retinoids in chemoprevention
L’acne tra mito e realtà: alimentazione, stress, fumo e altri indiziati.
No full textSi analizzano le potenziali implicazioni di dieta, stress emotivi e fumo di sigaretta nella patogenesi dell'acne, sulla base delle evidenze scientifiche di cui si dispone, dagli inizi del XX secolo ai giorni nostri
Follicoliti ed eruzioni acneiformi
No full textSi analizzano epidemiologia, clinica, patogenesi e le molecole più comunemente implicate nell'insorgenza delle eruzioni acneiformi da farmac
Onychomadesis following hand, foot, and mouth disease: a case report from Italy and review of the literature.
No full textHand, foot, and mouth disease (HFMD) is a relatively
common and highly contagious enteroviral infection that
occurs in small epidemics, usually in autumn or spring.
The illness primarily affects young children and is clinically
characterized by vesicular and erosive stomatitis in
combination with vesicular eruption of the palms and
soles, and, sometimes, a maculopapular rash. Outbreaks
of HFMD have been caused mainly by coxsackie virus
(CV) A16 and enterovirus 71, but CV strains A5, A7, A9,
A10, B1, B2, B3 and B5 have also been associated with
the illness.1 We report two cases of HFMD-related onychomadesis
in Italy and review the published data concerning
this emergent condition
Acne e Propionibacterium acnes.
No full textSi discutono le recenti acquisizioni sul ruolo di P.acnes nella fisiopatologia dell'acne, con particolare riferimento all'attivazione del sistema immunitario cutaneo e ai conseguenti processi infiammatori
Cicatrici postacneiche. Clinica e Terapia
No full textIl volume tratta il problema delle cicatrici post-acneiche in modo organico, affrontando nei primi capitoli la patogenesi, la clinica e le attuali proposte di classificazione morfologica. I capitoli seguenti analizzano il trattamento degli esiti cicatriziali post-acneici. Delle singole opzioni terapeutiche si specificano le indicazioni, efficacia e tollerabilità, sulla base delle evidenze scientifiche disponibili, e gli eventuali eventi avversi
Generalized lichen nitidus with oral and nail involvement in a child
No full textThe generalized form of lichen nitidus (LN) with oral and nail changes is extremely rare in childhood. We report a 10-year-old boy with generalized LN associated with oral involvement and onychodystrophy. Oral lesions showed yellowish papules on the gums. The nails had longitudinal striations and pits on the finger-nails, and transversal ridging of the big toes was found. Cutaneous and mucosal lesions as well as onychodystrophy spontaneously cleared within 8 months. © 1997 S. Karger AG, Basel
Adaplene 0.1% e benzoile perossido 2.5%: inquadramento terapeutico.
No full textSi analizza il ruolo dell'associazione fissa adaplene 0.1% - benzoile perossido 2.5% gel nella terapia dell'acne di grado lieve-moderato in monoterapia e in combinazione con l'antibiotico sistemico nel trattamento dell'acne di grado sever
Pseudotumor cerebri does not appear during oral isotretinoin therapy after a previous episode with minocycline for acne: Report of a case
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