1,721,255 research outputs found
Synthetic fuels by a limited CO2 emission process which uses both fossil and solar energy
No full textPRODUCTION OF SYNTHETIC GASOLINE AND DIESEL FUELS BY ALTERNATIVE PROCESSES USING NATURAL GAS AND COAL: PROCESS SIMULATION AND OPTIMIZATION
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Production of protein loaded polymeric micro-capsules by supercritical CO2 in mixed solvent
No full textIn view of developing new drug-delivery systems, microparticles of biocompatible polymer loaded with protein were produced using a supercritical antisolvent technique. As the polymer, poly(lactic acid) (PLA) of about 100 000 Da was used, whereas insulin was chosen as the protein model. To achieve microencapsulation, we started from a homogeneous solution of protein and polymer, to which the supercritical antisolvent is added; mixtures of dichloromethane and dimethyl sulfoxide were used to ensure the solubility of both the polymer and the protein. All experiments were performed in semicontinuous mode. A preliminary study with PLA alone was done in order to select the best operative condition and to control the particle dimension and their diameter distribution range, especially with mixtures of the two solvents. Then, the microspheres of PLA charged with insulin were produced; the average diameters ranged from 0.5 to 2 μm. The composition of these particles was determined analytically, and the protein bioactivity was checked
PREPARATION OF INSULIN LOADED POLYLACTIDES MICRO-PARTICLES BY SUPERCRITICAL ANTI-SOLVENT TECHNIQUES
No full textSimulated moving bed technology for continuous, countercurrent solid-fluid supercritical extraction
No full textCharacterization of a silica supported rhodium catalyst via hydrogen chemisorption, temperature programmed desorption and isotopic exchange measurements
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