1,720,990 research outputs found
Trying to unravel the bystander effects puzzle: a systematic study of cytokine pathways under different radiation exposures
No full textExperimental and theoretical study of cytokine release after gamma irradiation of human fibroblasts.
No full textInfluence of oxidative stress and di_erent radiation quality exposure on cytokine release
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Effect of imatinib metylate (STI571) in combination with gamma-radiation on astrocytoma cell survival
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Radiation induced perturbation of cell-to-cell signaling and communication
Full text linkThe investigation of the bystander phenomena (i.e. the induction of damage in cells not directly traversed by radiation) is
strictly related to the study of the mechanisms of intercellular communication and of the perturbative effects of radiation. A
new possible way to try to solve the bystander puzzle is through a ‘systems radiation biology’ approach with the total integration
of experimental and theoretical activities. In particular, this contribution will focus on: (1) ‘ad hoc’ experiments
designed to quantify key parameters involved in intercellular signalling (focusing, as a pilot study, on release, decay and
internalization of interleukine-6 molecules, their modulation by radiation, and possible differences between in vivo/in vitro behaviour);
(2) the implementation and the development of two different modelling approaches: a stochastic model (based on a
Monte Carlo code) that takes account of the local mechanisms of release and internalization of signalling molecules (e.g.
cytokines) and an analytical model where signal molecules are treated as a population and their temporal behaviour is
described by differential equations. This approach provided instruments to investigate the complex phenomena of signal transmission
and the role of cell communication to guarantee (maintain) the robustness of the in vitro experimental systems
against the effects of perturbations
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