1,721,513 research outputs found
Gene Co-Expression in Postmortem Brain Tissue Reveals the Role of Dopamine Receptor D2 in Prefrontal Cortical Networks
No full textSchizophrenia research offers a wealth of unanswered questions, but one thing we do know is that the dopamine receptor D2 is fundamental to psychosis and risk for schizophrenia. Genetic variation associated with DRD2 mRNA is associated with brain activity and connectivity, and we are only beginning to unravel how genetic variants exert their function at system-level
Modeling and analysis of non-functional properties in component-based systems
No full textAbstractThis paper discusses methodologies for the specification and analysis of performance related properties of components and assemblies of components, and outlines an original approach, called the CB-SPE, for component-based software performance engineering. The proposed approach relies on, and adapts to a CB framework, the concepts and steps of the SPE technology, and uses for modeling the standard RT-UML profile, reshaped according to the CB principles
Functional imaging as a tool to investigate the relationship between genetic variation and response to treatment with antipsychotics
No full textRecent evidence suggests that genetic variation is associated with individual variability in response to treatment with antipsychotics. Although numerous studies have been performed for identification of potential genetic variants affecting response to treatment, initial enthusiasm has been tempered by inconsistent results. Along with some specific methodological issues, another plausible explanation for such inconsistencies is lack of sensitivity of the phenotype ( clinical measures) used to define response. In this paper, we review use of Imaging Genetics, a relatively new approach that combines genetic assessment with functional neuroimaging, to explore in vivo neurobiological effects of genetic variation. Moreover, we propose to use Imaging Genetics as a tool to evaluate and predict response to treatment with antipsychotics based on the individual genetic makeu
. [Changes in the homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) levels of the rat brain after acute and chronic treatment with ethanol]
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Rationale for the pharmacological interventions in anxiety disorders [Razionale per gli interventi farmacologici nei disturbi d'ansia]
No full textA New Test Rig for Electrically Actuated Landing Gear and Brake of a Small Transport Aircraft
No full textPerforming highly representative tests of aircraft equipment is a critical feature for gaining utmost confidence on their ability to perform flawlessly in flight under the entire spectrum of operating conditions. This can also contribute to accelerate the certification process of a new equipment. A research project (E-LISA) was performed in recent years, as part of the European funded Clean Sky 2 framework, with the objective of building an innovative facility for testing an electrically actuated landing gear and brake for a small air transport. The project eventually led to the development and construction of an Iron Bird able to reproduce in a realistic and comprehensive way a full variety of landing test cases consistent with certification specifications and landing histories available in the repository of the airframer. The Iron Bird that was eventually developed is a multi-functional intelligent and easy reconfigurable facility integrating hardware and software allowing to perform a full verification and validation of an electrically actuated landing gear and brake over the representative operating conditions, and under normal, degraded and faulty conditions
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