1,721,166 research outputs found
Correlation between Progetto Cuore risk score and early cardiovascular damage in never treated subjects
Full text linkValutazione della correlazione tra un punteggio di rischio validato, quale quello del Progetto Cuore per la popolazione italiana, ed il danno cardiovascolare subclinico in un' ampia popolazione di soggetti affetti da seindrome metabolic
K→ππ hadronic matrix elements of left-right current-current operators
No full textEffective S 1⁄4 1 four-fermion operators involving left- and right-handed currents are relevant in left-right gauge extensions of the Standard Model and scalar extension of the Yukawa sector. They induce K ! %% decays which are strictly constrained by experimental data, typically resulting in strong bounds on the new physics scales or parameters. We evaluate the K ! %% hadronic matrix elements of such operators within the phenomenological framework of the chiral quark model. The results are consistent with the estimates used in a previous work on TeV scale left-right symmetry, thus confirming the conclusions obtained there
Lipoproteins, stroke and statins.
No full textDyslipidemia represents one of the major risk factors for atherosclerosis affecting the arteries of large and medium caliber and consequently causing ischemia in the brain, heart, or legs. Coronary artery disease and cerebral stroke represent the major causes of morbidity and mortality among the elderly and middle aged subjects. The change of lifestyle can reduce the risk of cardiovascular disease but available drug therapy (in particular statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase) is effective in modifying hyperlipidemia and consequently reducing cardiovascular events. The hypolipemic drugs can prevent, slow the progression and sometimes determine the regression of atherosclerotic plaques, therefore significantly reducing the clinical complications of atherosclerotic cardiovascular disease. In this review, we want to point out the role of the different lipoproteins, such as triglycerides, HDL-C, LDLC, Lp(a), in the pathogenesis of stroke and the role of statins in reducing both lipid fractions and stroke risk
Present and future K and B meson mixing constraints on TeV scale left-right symmetry
No full textWe revisit the ΔF 1⁄4 2 transitions in the K and Bd;s neutral meson systems in the context of the minimal left-right symmetric model. We take into account, in addition to up-to-date phenomenological data, the contributions related to the renormalization of the flavor-changing neutral Higgs tree-level amplitude. These contributions were neglected in recent discussions, albeit formally needed in order to obtain a gauge- independent result. Their impact on the minimal LR model is crucial and twofold. First, the effects are relevant in B meson oscillations, for both CP conserving and CP violating observables, so that for the first time these imply constraints on the LR scenario which compete with those of the K sector (plagued by long- distance uncertainties). Second, they sizably contribute to the indirect kaon CP violation parameter ε. We discuss the bounds from B and K mesons in both cases of LR symmetry: generalized parity (P) and charge conjugation (C). In the case of P, the interplay between the CP-violation parameters ε and ε0 leads us to rule out the regime of very hierarchical bidoublet vacuum expectation values v2=v1 < mb=mt ≃ 0.02. In general, by minimizing the scalar field contribution up to the limit of the perturbative regime and by definite values of the relevant CP phases in the charged right-handed currents, we find that a right-handed gauge boson WR as light as 3 TeV is allowed at the 95% C. L. This is well within the reach of direct detection at the next LHC run. If not discovered, within a decade the upgraded LHCb and Super B factories may reach an indirect sensitivity to a left-right scale of 8 TeV
Pvu II polymorphism of low density lipoprotein receptor gene and familial hypercholesterolemia. Study of Italians.
No full text
Evaluation of RNA messangers involved in lipid trafficking of human intestinal cells by RT-PCR with competimer technology and microchip electrophoresis.
No full textAPOA5 and triglyceride metabolism, lesson from human APOA5 deficiency.
No full textPURPOSE OF REVIEW:
In this review we compare the phenotype and lipoprotein abnormalities of some patients who were found to carry mutations in the APOA5 gene predicted to result in apolipoprotein A-V deficiency.
RECENT FINDINGS:
The sequencing of the APOA5 gene in patients with primary hypertriglyceridemia, in whom mutations of the LPL and APOC2 genes had been excluded, led to the identification of four families with two different mutations in this gene predicted to result in truncated apolipoprotein A-V. The first mutation (Q148X) was found in a homozygous state in a child with severe type V hyperlipidemia, some clinical manifestations of chylomicronemia syndrome and a slight reduction in plasma postheparin lipoprotein lipase activity. Carriers of a different mutation (Q139X) were recently reported. Four Q139X heterozygotes had type V hyperlipidemia and markedly reduced plasma postheparin lipoprotein lipase activity. The hypertriglyceridemic Q139X heterozygote had other factors that could have contributed to hypertriglyceridemia. ApoB-100 kinetic studies in hypertriglyceridemic Q139X heterozygotes revealed an impairment of very low-density lipoprotein catabolism.
SUMMARY:
Mutations in the APOA5 gene, leading to truncated apolipoprotein A-V devoid of lipid-binding domains located in the carboxy-terminal end of the protein, if present in the homozygous state, are expected to cause severe type V hyperlipidemia in patients with no mutations in LPL or APOC2 genes. If present in the heterozygous state, these mutations predispose to hypertriglyceridemia in combination with other genetic factors or pathological conditions
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