1,721,117 research outputs found
Biology and Pathophysiology of Bone Metastasis in Prostate Cancer
No full textINel capitilo vengo presentate le più recenti acquisizioni in merito alla fisiopatlogia della malattia metastatica ossea e dell'interazine tra microambinete osteomidollare e cellula neopalstcia, dalla formazione della nicchia premetasatica alla sviiluppo della metastasi clinicaSeveral studies have attempted to correlate the extent of skeletal metastatic involvement, the number of bone metastases (BMTs) identified by bone scintigraphy or the distribution of BMTs (axial vs appendicular) with survival in patients with advanced prostate cancer (PC) [1, 2]. The number of BMTs has recently been evaluated as a prognostic predictor [3]. Patients with metastatic castration-resistant PC with a higher number of BMTs had a shorter progression-free survival (PFS) and overall survival (OS; hazard ratio 2.0; 95 % confidence interval 1.7–2.4). Patients with 1–4 BMTs have much better PFS and OS than those with 5–20 BMTs [4]. It should, however, be taken into account that among the predictors of prognosis, coexisting non-osseous metastatic disease is an important determinant of prognosis in patients with BMTs [5,
Markers of Bone Turnover in Bone Metastasis from Prostate Cancer
No full textIl cpaitolo riporta le più recenti acquisizioni sul ruolo del turnover osseo nella patogenesi e nel management della lesione metastatic e discute per ogni marcatore le performance clniche nella diagnosica , nel loro significato prognostico e nel loro ruolo nel follow up terapeutic
Bisphosphonates and osteonecrosis of the mandible/maxilla in osteoporosis: no reason to panic
No full text
Obesità e osteoporosi
No full textil capitolo tratta dell'epidemiologia dell'osteoporosi e delle fratture dafragilità nell'obeso e delle correlazioni fisiopatologiche e endocrinometaboliche tra tessuto adiposo e tessuto osseo
Bisphosphonates and osteomyelitis of the jaw: a pathogenic puzzle.
No full textThe maxillary and mandibular bones undergo high-turnover remodeling to maintain mechanical competence. Common dental or periodontal diseases can increase local bone turnover. Bisphosphonates (BPs) accumulate almost exclusively in skeletal sites that have active bone remodeling. The maxillary and mandibular bones are preferential sites for accumulation of BPs, which become buried under new layers of bone and remain biologically inactive for a long time. Surgical odontostomatological procedures create open bony wounds that heal quickly and without infection, as a result of activation of osteoclasts and subsequently osteoblasts. Once BPs are removed from the bone via activation of osteoclasts after a tooth extraction or a periodontal procedure, they induce osteoclast apoptosis. This inhibition of osteoclast bone resorption impairs bone wound healing because of decreased production of cytokines derived from the bone matrix, and the bone is exposed to the risk of osteomyelitis and necrosis. The pathogenic relationship between BPs and osteonecrosis of the jaw is unclear, but there is evidence to indicate an association between high-dose BP treatment and exposure to dental infections or oral surgical procedures. A better knowledge of the interactions between BPs and jaw and maxillary bone biology will improve clinical and therapeutic approaches
nUOVE PROSPETTIVE NELL'UTILIZZO DEI BISFOSFONATI IN ONCOLOGIA:OLTRE LA METASTASI OSSEA
No full textVi snon crescenti evidenze che i bsifosofnati possono avere un efeffto antineoplastcio in modelli in vitro e in modelli animali. Recentemente anche nell'uomo vi sono dati di un effetto antinmeoplastico diretto ed indirett
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