1,720,967 research outputs found
Fluorescence in sections of rat cardiac muscle treated with 4'-O-tetrahydropyranil-adriamycin hydrochloride (THP) or with adriamycin hydrochloride. Similarities and differences in the histological pictures
No full textEFFECTS OF WHITE WINE, COKE AND WATER ON BASAL AND FOOD-STIMULATED GASTRIC-ACID SECRETION AND GASTRIN-RELEASE IN THE DOG
No full textInfluenza dell'alcool e di alcune bevande alcoliche (vino e birra) sulla secrezione gastrica e la liberazione di gastrina nel cane
No full textEffect of some white wine phenols in preventing inflammatory cytokine release
No full textSome well-known antioxidant phenois present in extravirgin olive oil have also been found in white wine. Both tyrosol and caffeic acid are phenols that are present not only in extravirgin olive oil, but also in wine, especially white wine. Their antioxidant properties are well known, but their biological effects have not yet been elucidated. In a previous study we found that these substances were able to inhibit tumor necrosis factor a release. The present study was carried out to assess whether these compounds are able to inhibit other inflammatory cytokines, such as interleukin-1beta and interleukin-6. The results show that low concentrations of these phenols, which can be found in the bloodstream after intake of moderate quantities of white wine, exert significant inhibitory activity on the release of several inflammatory cytokines
Inhibitory activity of the white wine compounds, tyrosol and caffeic acid, on lipopolysaccharide-induced tumor necrosis factor-alpha release in human peripheral blood mononuclear cells
No full textThe objective of this study was to assess whether tyrosol and caffeic acid are able to inhibit lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha release. TNF is one of the most important cytokines involved in inflammatory reactions. The results show that both tyrosol and caffeic acid are able to inhibit LPS-induced TNF-alpha release from human monocytes, even at low doses. Their mechanisms of action are discussed and we conclude that high doses of the two compounds are not required to achieve effective inhibition of inflammatory reactions due to TNF-alpha release
L-propionyl carnitine reduces toxicity correlated to cyclosporine-induced intracellular ATP concentrations
No full textIn previous trials we proved how propionyl carnitine, an acyl carnitine characterized by its intense mitochondrial metabolic, and cardio and vasoprotective activity could prevent the cyclosporine-induced nephrotoxicity. Subsequently we also noted how propionyl carnitine could prevent the increase in renal intracellular calcium, which is the base of many cyclosporine-induced toxic phenomena. In our trials, we used the isolated and perfused rat kidney technique to examine if with the variations of the concentration of intracellular calcium, the adenosine 5'-triphosphate concentrations also varied, and if this decrease could be corrected by administrating propionyl carnitine. The results we obtained in these experiments indicated that when propionyl carnitine was administered preventively the concentrations of renal intracellular adenosine 5'-triphosphate which were decreased by the cyclosporine returned to their normal values and, at the same time, a decrease in the increased vascular resistance of the kidney was noted. Therefore, propionyl carnitine corrected one of the biochemical alterations which explained the pathogenesis of the renal damage induced by cyclosporine
Acute cyclosporine A nephrotoxicity: Protective effect of L-propionylcarnitine on lipid peroxidation in isolated and perfused rat kidney (IPRK).
No full textResveratrol prevents interleukin release from isolated monocytes
No full textPrevious studies have shown that resveratrol, a phytoalexin present with other phenols in grapes and wine, inhibits the release of inflammatory cytokines from human isolated monocytes. The present study demonstrates that the presence of resveratrol inhibits the release of interleukin (IL)-1-alpha and IL-6 induced by lipopolysaccharide, These results confirm the modulatory effects of resveratrol on the nuclear factor-kappaB and activator protein 1 signal transduction systems, thus explaining the possible mechanisms of antiinflammatory antiatherosclerotic and cardioprotective activity of resveratrol
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