1,721,641 research outputs found
5th International ACC Symposium: Future and Current Therapeutic Trials in Adrenocortical Carcinoma
No full textAdrenocortical carcinoma (ACC) is a rare and complex disease associated with a high mortality rate. Despite intensive translational and clinical research, prognosis remains poor. Over the past decade, a significant effort has been made to develop multinational, collaborative studies to better understand the pathogenesis and clinical features of this rare disease in attempt to improve the therapeutic strategies and patient outcome. The results of both standard and newer treatments are discussed in this review as well as the recent discovery of pathways involved in ACC pathogenesis that provide the rationale to introduce new molecular target therapies. Finally, remaining issues regarding how to improve available therapies in adjuvant setting are raised and addressed
Neoadjuvant androgen deprivation therapy through intense inhibition of the androgen target: "Midsummer Night's Dream" or "Much Ado About Nothing"?
No full textRe: Christan Walter, Bilal Al-Nawas, Knut A. Grötz, et al. Prevalence and risk factors of bisphosphonate-associated osteonecrosis of the jaw in prostate cancer patients with advanced disease treated with zoledronate. Eur Urol 2008;54:1066-72.
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Why denosumab obtains a survival benefit over zoledronic acid in bone metastatic lung cancer patients?
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