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A pheochromocytoma with normal clonidine-suppression test: how difficult the biochemical diagnosis?
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Depression in vascular pathologies: the neurologist point of view.
No full textThe coexistence of depression and cardiovascular disease (CVD) is regularly
discussed, and much debated. There is strong evidence that there are pathophysiological mechanisms,
particularly endothelial dysfunction, altered platelet aggregation, and hyperactivation
of the thrombosis cascade, which coexist with hypothalamic-pituitary-adrenocortical axis
dysfunction, and link depression to CVD. Therefore, depression should not be automatically
considered to be a consequence of life impairment due to myocardial infarction or major stroke.
Probably, it should be considered as one of the many other stressful events, or “genetic reactions
to life”, which are risk factors for CVD development. This review will examine the significance
of depression in clinical daily practice, its pathophysiology as a determinant in vascular events,
and its real importance in, before, and after many CVD event
Antihypertensive treatment and renal damage. Amlodipine exerts protective effect through the polyol pathway.
No full textBesides generating renal damage, hypertension plays an important role in the progression of diabetic nephropathy. The fructose-fed rat is a well-established model both of high blood pressure and renal impairment, which is similar to diabetic nephropathy. To clarify the relationship between hypertension, glucose metabolism, and kidney remodeling, we investigated the renal level of Glut 1 and Glut 5, their relation to fibrosis and the effects of an antihypertensive drug on renal damage. Twenty-four male WK rats were divided into three groups: 8 animals received a fructose-enriched diet, 8 a control diet, and 8 animals a high-fructose diet plus amlodipine (5 mg/Kg). After six weeks of treatment, we observed a significant increase in Glut 5, fibronectin, and sorbitol in fructose-fed rats compared with control and amlodipine-treated animals; there was a positive correlation between Glut 5 and fibronectin levels (r = 0.63). Glut 1 levels were similar in all three groups, whereas collagen IV was higher in fructose-fed rats; amlodipine prevented the increase of collagen IV and sorbitol. Collagen I was statistically higher in the fructose group than in the other two groups. Therefore, prolonged fructose feeding results in renal fibrosis via polyol pathway overactivity that can be prevented by means of an antihypertensive drug
eFFETTO DELLA DOXAZOSINA SUI FATTORI DI RISCHIO CARDIOVASCOLARE E SULLA FUNZIONE NERVOSA PERIFERICA IN PAZIENTI IPERTESI E DIABETICI: FOLLOW-UP A 12 MESI.
No full textLosartan normalizes blood pressure and reverses renal and cardiac changes in rats on high fructose diet
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