1,720,966 research outputs found
Functional and post-genomic investigation of the molecular basis of schizophrenia.
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Expression in Escherichia coli and in vitro refolding of the human protein pLG72
No full textRecently, genes coding for pLG72 and D-amino acid oxidase have been related to schizophrenia, a widespread psychiatric disorder that affects about 1% of population. pLG72 is a puzzling, novel protein present only in primates and proposed to be an activator of Damino acid oxidase. Here we report on the overexpression of wild-type and His-tagged pLG72 in Escherichia coli. Both variants form inclusion bodies and have been refolded and purified to homogeneity: the acquisition of secondary and tertiary structure was demonstrated by CD spectroscopy. A figure of 70mg of pure protein per liter of fermentation broth was achieved
Examination of pLG72 and D-Amino Acid Oxidase interaction as molecular basis of Schizophrenia.
No full textInvestigating D-Amino Acid Oxidase and pLG72 as potential targets of the antipsychotic drug chlorpromazine.
No full textInvestigating the molecular basis of schizophrenia: the effect of pLG72 interaction on the functionality of human D-amino acid oxidase
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Molecular basis of schizophrenia: functional investigation of human D-amino acid oxidase-pLG72 interaction.
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