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Platinum-assisted preparation of PS ligands containing chiral centres; X-ray crystal structure of a dithiophosphinite platinum complex
No full textThe design and synthesis of some ligands containing P(III) bonded to sulphur (thiophosphinites) and chiral centres is described in this paper.
Their complexes with platinum (II), [PtCl2L], (L = bidentate dithiophosphinite) have been prepared and characterized and it has been shown that in many cases, the coordination to platinum protects these ligands from decomposition processes operated by moisture and oxygen. The first example of X-ray crystal structure of a platinum coordinated dithiophosphinite is described for complex cis-[PtCl2L], [L = meso-2,3-bis(diphenylthiophosphinito)-dimethyl-succinate], 4a
Photochemical reactivity of 2[IrIIIHCl2(PPri3)2].H2. Formation of monohydrido isomers of Ir(III) and evidence of photoinduced oxidative addition of H2 to Ir(III).
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Formation of threonic acid via ascorbic acid oxidative ring opening and its coordination to Pt(II). X-ray crystal structure of [Pt(threonate-O,O')(PPh3)2]
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Vicinal Multifunctional Compounds. Tautomerism and Isomerism in the Condensation Products of 2-Hydroxyimino-3-oxobutanal or 3-Hydroxy-iminopentane-2.4-dione with Benzylamines.
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Synthesis, characterization and antiproliferative activity of amino- and DMSO complexes of platinum(II) containing L-carnitine
No full textL-Carnitine, a biomolecule able to cross the blood-brain barrier exploiting specific transporters, behaves as mono or bidentate anionic ligand for Pt(II) in the new amino complexes cis-[Pt(L-carnitine-O)2(NH3)2](BF4)2 (1), cis-[PtCl(L-carnitina-O)(NH3)2]BF4 (2), [Pt(L-carnitine-O,O’)(1,2-DACH)]BF4 (3), [Pt(L-carnitine-O)2(1,2-DACH)](BF4)2 (4), and [PtCl(L-carnitine-O)(1,2-DACH)](BF4) (5). Four complexes with DMSO have been also prepared and characterized: the synthetic intermediate [Pt(CO3)(DMSO)2] (6), [Pt(L-carnitine-O,O’)(DMSO)2]BF4 (7), cis-[Pt(L-carnitine-O)2(DMSO)2](BF4)2 (8) and cis-[PtCl(L-carnitine-O)(DMSO)2]BF4, (9).
The antiproliferative activity of three representative complexes 1, 5 and 7 has been assayed against three human cancer cell lines A2780, K562 and SKOV3, and it was found comparable to that of the parent active compounds cis-[PtCl2(1,2-DACH)] and cisplatin
Generation of Reactive Intermediates in the Photochemistry of Binuclear Trihydridodiplatinum Complexes
No full textThe photochemistry of the complexes trans-trans monohydrido-bridged [(PEt3)2HPt(μ-H)PtH(PEt3)2][BPh4] (1) and trans-cis dihydrido-bridged [(PEt3)2HPt(μ-H)2Pt(PEt3)2] [BPh4] (2) is reported. Photolysis of 1 and 2 using 334-nm light occurs with good quantum yields to give irani-[PtH2(PEt3)2] (3a) and (ra/i5-[PtH(S)(PEt3)2]+(4) (S = solvent, e.g. acetonitrile). Photoproducts 3a and 4 are highly reactive and undergo a multiplicity of reactions depending upon experimental conditions. Evidence of H2elimination, photoinduced insertion of C02into the Pt-H bond of 3a, and abstraction of CI from chlorocarbon solvents by 3a and 4 is reported. © 1990, American Chemical Society. All rights reserved
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