1,721,187 research outputs found
THE THIRD EUROPEAN CONGRESS ON BIOGERONTOLOGY: THE BIOGERONTOLOGICAL BASIS OF PREVENTIVE MEDECINE AND GERIATRIC PRACTICE
No full textAutophagy: a cell repair mechanism that retards ageing and age-associated diseases and can be intensified pharmacologically
No full textNICOTINAMIDE AND STREPTOZOTOCIN DIABETES IN RAT - FACTORS INFLUENCING EFFECTIVENESS OF PROTECTION
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Response to"increased bioactivity of rat atrial extracts: relation to aging and blood pressure regulation"
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Changes in the transmural distribution of glucose-metabolizing enzymes across the left and right ventricular wall of rat heart during growth and ageing.
No full textThe age-related changes in the activities of five glucose-metabolizing enzymes
(hexokinase, HK; glucose-6-phosphate dehydrogenase, G6P-DH; aldolase, ALD;
phosphofructokinase, PFK; and lactate dehydrogenase, LDH) were investigated in
the walls of left and right ventricles of rats of various age-groups (1-24
months). Age-related changes were found in the activities of all of the enzymes
in both ventricles during growth (with significant decreases between 2 and 6
months of age) and in the levels of PFK and LDH in the left ventricle during
ageing (with a significant increase between 12 and 24 months of age). The
distribution of the enzyme activities across the wall of both ventricles was
quite uniform in young, adult and mature rats (the distribution of G6P-DH
activity in the left ventricle wall at 2 months of age was the only notable
exception) but became non-uniform in the old rats with regard to G6P-DH, PFK, LDH
and probably HK in the left ventricle and G6P-DH and HK in the right ventricle.
These data support the hypothesis that alterations connected with ageing do not
lead to a generalized decline of cardiac metabolic capacity, and that they are
also the result of specific adaptive modifications, perhaps related to alteration
in the distribution of the work load and/or of nutrition across the ventricular
wall
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