1,204 research outputs found
MCbiclust: a novel algorithm to discover large-scale functionally related gene sets from massive transcriptomics data collections
No full textThe potential to understand fundamental biological processes from gene expression data has grown in parallel with the recent explosion of the size of data collections. However, to exploit this potential, novel analytical methods are required, capable of discovering large co-regulated gene networks. We found current methods limited in the size of correlated gene sets they could discover within biologically heterogeneous data collections, hampering the identification of multi-gene controlled fundamental cellular processes such as energy metabolism, organelle biogenesis and stress responses. Here we describe a novel biclustering algorithm called Massively Correlated Biclustering (MCbiclust) that selects samples and genes from large datasets with maximal correlated gene expression, allowing regulation of complex networks to be examined. The method has been evaluated using synthetic data and applied to large bacterial and cancer cell datasets. We show that the large biclusters discovered, so far elusive to identification by existing techniques, are biologically relevant and thus MCbiclust has great potential in the analysis of transcriptomics data to identify large-scale unknown effects hidden within the data. The identified massive biclusters can be used to develop improved transcriptomics based diagnosis tools for diseases caused by altered gene expression, or used for further network analysis to understand genotype-phenotype correlations
Drawing of Benjamin E. Mays, circa 1960
No full textA drawing of Benjamin E. Mays. Written on recto: Presented to Dr. Benjamin E. Mays By Class Historian: Ernest W. Wright for Dr. May's first Morehouse graduating class- 1941
Past and future sea-level rise along the coast of North Carolina, USA
No full textWe evaluate relative sea level (RSL) trajectories for North Carolina, USA, in the context of tide-gauge measurements and geological sea-level proxy reconstructions spanning the last ∼11,000 years. RSL rise was fastest (∼7 mm/yr) during the early Holocene and slowed over time with the end of the deglaciation. During the pre-Industrial Common Era (i.e., 0–1800 CE), RSL rise (∼0.7 to 1.1 mm/yr) was driven primarily by glacio-isostatic adjustment, though dampened by tectonic uplift along the Cape Fear Arch. Ocean/atmosphere dynamics caused centennial variability of up to ∼0.6 mm/yr around the long-term rate. It is extremely likely (probability P = 0.95) that 20th century RSL rise at Sand Point, NC, (2.8 ± 0.5 mm/yr) was faster than during any other century in at least 2,900 years. Projections based on a fusion of process models, statistical models, expert elicitation, and expert assessment indicate that RSL at Wilmington, NC, is very likely (P = 0.90) to rise by 42–132 cm between 2000 and 2100 under the high-emissions RCP 8.5 pathway. Under all emission pathways, 21st century RSL rise is very likely (P > 0.90) to be faster than during the 20th century. Due to RSL rise, under RCP 8.5, the current ‘1-in-100 year’ flood is expected at Wilmington in ∼30 of the 50 years between 2050-2100.The final publication is available at Springer via http://dx.doi.org/10.1007/s10584-015-1451-xPeer reviewe
Benjamin E. Mays, August 9, 1951
No full textBenjamin E. Mays and his wife stand in front of a cake on their 25th wedding anniversary. Written on verso: The ice tea spoon you sent are so nice - we saved you the trouble and exchanged them for two that matched our set.The Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the National Endowment for Humanities - Humanities Collections and Reference Resources Implementation Project Grant in supporting the processing and digitization of a number of its major archival collections as part of the project: Spreading the Word: Expanding Access to African American Religious Archival Collections at the Atlanta University Center Robert W. Woodruff Library.</em
Banquet Speech, Atlanta, GA. Dr. Benjamin E. Mays presentation, History of Black Churches. C.S. Rooks
No full textThis recording features a presentation by Benjamin E. Mays, featuring an explanation on the role of the Black Church in the liberation process in America. The presentation is taken over by Charles Shelby Rooks and James Cone after Mays has some difficulty. Each proceeds to read about the organization of the Black church and the help given by whites to the efforts of the Black church.The Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the National Endowment for Humanities - Humanities Collections and Reference Resources Implementation Project Grant in supporting the processing and digitization of a number of its major archival collections as part of the project: Spreading the Word: Expanding Access to African American Religious Archival Collections at the Atlanta University Center Robert W. Woodruff Library.</em
Public worship and practical theology in the work of Benjamin Keach (1640-1704)
No full textThe late seventeenth century was a critical and fruitful period
for the Particular Baptists of England. Severely persecuted following
the Restoration, toleration in 1689 brought its own perils.
Particular Baptists were fortunate in having several strong leaders,
especially the London trio of Hanserd Knollys, William Kiffin, and
Benjamin Keach. Such a small and severely persecuted group as the
Baptists could afford little time for academic pursuits, thus of
necessity most of their theology was practical in nature.
Benjamin Keach (1640-1704) was the most outstanding practical
theologian among the English Particular Baptists of the late
seventeenth century. This dissertation is a study of Keach, in
particular his writings on public worship and practical theology.
Although Keach was a prolific author, he has been almost completely
neglected by scholars.
After a biographical sketch of Keach, this study considers his
writings on public worship and practical theology. In the area of
worship, Keach made two outstanding contributions: First, he was the
most vocal apologist for Baptist views on Baptism of his period.
Secondly, and more importantly, his hymn writing and defense of hymn
singing broke new ground, not just for Baptists, but for English
Protestantism, in general. In addition to his contributions in these
areas, he also dealt with the laying on of hands and the sabbath day
worship controversy.
Keach's contributions to practical theology fall into two main
groups: his writings that concern religious education and those that
deal with polity. In addition to these, Keach's vigorous advocacy of
a high Calvinist soteriology are also considered under the rubric of
practical theology. Keach's most important (although not his most
positive) contribution in this area were his soteriological writings.
Although well within the bounds of orthodoxy, some of the tendencies
in Keach's soteriology were taken up by the following generation of
Baptist leaders and developed into a stultifying hyper-Calvinism that
handicapped Baptist evangelism and missions.
In the conclusion, Keach's contributions to a theory of practical
theology are considered
Sea-Level change and subsidence in the Delaware Estuary during the last ~2200 years
No full textWe produced eight new sea-level index points that reconstruct a ~2.5 m relative sea-level (RSL) rise at Sea Breeze in the Delaware Bay from ~200 BCE to 1800 CE. The precision of our reconstruction improved upon existing data by using high-resolution surveying methods, AMS radiocarbon dating of in-situ plant macrofossils collected immediately above the basal contact between pre-Holocene sand and salt-marsh sediments, foraminifera as sea-level indicators, and by accounting for tidal range changes through time. Our new data were combined with a database of 65 sea-level index points available for the Delaware Bay to estimate the rate of RSL rise in the upper (1.26 ± 0.33 mm/yr) and lower bay (1.30 ± 0.36 mm/yr) using a spatial-temporal model. Correction for changes in tidal range through time removed the disparity in rate between the upper and lower Delaware Bay that had previously been postulated. After paleotidal correction, the rates of RSL rise estimated for the Delaware Bay (1.25 ± 0.27 mm/yr) correlate with the ~1.3 mm/yr rate reported for New Jersey, Maryland, and Virginia, and confirm that the maximal ongoing forebulge collapse along the U.S. Atlantic coast is focused on the mid-Atlantic.Peer reviewe
James Farmer, Benjamin Hooks, and Unidentified Man, circa 1965
No full textBenjamin Hooks (in middle) is shown holding James Farmer's arm (on the left) alongside an unidentified man in front of a building.The Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the Joseph & Evelyn Lowery Institute for Justice and Human Rights, the Joseph Echols Lowery Irrevocable Trust, and other donors in supporting the processing and digitization of Morehouse College's Joseph Echols and Evelyn Gibson Lowery Collection
Benjamin E. Mays Papers
No full textBenjamin Elijah Mays was born August 1, 1894 in Ninety Six, South Carolina. After graduating high school, he spent one year at Virginia Union University before moving to Maine to attend Bates College, where he received his BA. He then went to the University of Chicago for his M.A. and his Ph.D. While at the University of Chicago, Mays worked as a Pullman Porter and a student assistant to Dr. Lacey Kirk Williams, pastor of Olivet Baptist Church. While finishing his doctorate, Mays published The Negro's Church, the first sociological study on the Black church, with Joseph Nicholson. He became dean of the School of Religion at Howard University in 1934. In 1940, Mays moved to Atlanta to become the president of Morehouse College. Martin Luther King Jr. was Mays' most famous student at Morehouse. The two remained close until King's death in 1968 and Mays delivered the eulogy at his funeral. Mays left Morehouse College in 1967. In 1969, Mays ran for the Atlanta Public Schools Board of Education. While on the board, Mays oversaw the peaceful desegregation of the Atlanta Public Schools. He served on the board until 1981, and served as the president of the board between 1970 and 1981.
At the AUC Robert W. Woodruff Library we are always striving to improve our digital collections. We welcome additional information about people, places, or events depicted in any of the works in this collection. To submit information, please contact us at [email protected]
APCUG Higher Education Awards Banquet, March 26, 1973
No full textBenjamin E. Mays and others at an APCUG Higher Education Awards Banquet. Written on verso: APCUG Higher Education Awards Banquet, Stouffer's Atlanta [?], 7 p.m. March 26, 1973, L to R: President Waights Henry, Lagrange College, Dr. Benjamin E. Mays, Mayor Sam Massell. Benjamin E. Mays attends APUCG High Education Banquet
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