1,720,983 research outputs found

    Mathematical methods and tools of kinetic theory towards modelling complex biological systems

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    This paper develops a variety of mathematical tools to model the dynamics of large systems of interacting cells. Interactions are ruled not only by laws of classical mechanics, but also by some biological functions. The mathematical approach is the one of kinetic theory and non-equilibrium statistical mechanics. The paper deals both with the derivation of evolution equations and with the design of specific models consistent with the above-mentioned mathematical framework. Various hints for research perspectives are proposed in the last part of the paper

    On the derivation of macroscopic hyberbolic equations for binary multicellular growing mixtures

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    AbstractThis paper presents an asymptotic theory, based on the hyperbolic scaling, for a large class of Boltzmann-type equations suitable to model the evolution of a binary mixture of multicellular systems in biology. The modelling approach is that of the kinetic theory for active particles. Time scaling related to cell movement and biological activity are shown to play a crucial role in determining the macroscopic equations corresponding to each case. Applications are focused on the immune competition

    Asymptotic limits of a discrete kinetic theory model of vehicular traffic

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    AbstractThe paper proposes a rigorous method to construct the hyperbolic asymptotic limit of the discrete Kinetic Theory model of vehicular traffic proposed in [8]. A second-order macroscopic model of the Payne–Whitham type is derived and the coefficients of the equations are obtained from the detailed description of the microscopic interactions developed in the kinetic model

    Mathematical topics on the modelling complex multicellular systems and tumor immune cells competition

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    This paper deals with a critical analysis and some developments related to the mathema- tical literature on multiscale modelling of multicellular systems involving tumor immune cells competition at the cellular level. The analysis is focused on the development of mathematical methods of the classical kinetic theory to model the above physical sys- tem and to recover macroscopic equation from the microscopic description. Various hints are given toward research perspectives, with special attention on the modelling of the interplay of microscopic (at the cellular level) biological and mechanical variables on the overall evolution of the system. Indeed the nal aim of this paper consists of organizing the various contributions available in the literature into a mathematical framework suitable to generate a mathematical theory for complex biological systems
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