196,192 research outputs found
Banche locali e private equity: quali sfide culturali e organizzative alla luce della crisi finanziaria internazionale
No full textQuesto contributo intende descrivere gli eventuali mutamenti portati dalla crisi finanziaria globale sul
mercato italiano del private equity osservando contestualmente il lato della domanda e dell’offerta
caratterizzante tale comparto finanziario.
Dal lato della domanda, questo ampliamento temporale intende rispondere al tentativo di descrivere le
principali le eventuali ricadute della crisi finanziaria in termini di trend di tale comparto e delle
caratteristiche settoriali, dimensionali e reddituali delle imprese target.
Dal lato dell’offerta questo lavoro intende verificare se, a seguito della crisi finanziaria globale, la categoria
di intermediario bancario rappresentata dalle banche locali (ossia banche di credito cooperativo e banche
popolari) ha modificato il proprio modus operandi per poter assumere maggiormente la fisionomia di
intermediario diversificato nelle aree di business del corporate e investment banking ed in particolare nel
segmento del merchant banking.
Con riferimento a quest’ultimo aspetto si è cercato di tracciare brevemente l’evoluzione del ruolo del
soggetto bancario e, in particolare, della banca locale, nell’attività di private equity a sostegno delle imprese
a livello nazionale realizzando due analisi: dapprima una di natura descrittiva e successivamente
un’empirica
ESTROGENS MODULATE MACROPHAGE MIGRATION INHIBITORY FACTOR(MIF) EXPRESSION IN HUMAN CULTURED CHORIONIC VILLOUSEXPLANTS
No full textObjectives: Macrophage Migration Inhibitory Factor (MIF) is a cytokine originally identified
for its capacity to inhibit the random migration of macrophages in vitro. MIF is
a key regulator of the inflammatory and immune responses. We recently demonstrated
that MIF is abundantly expressed in first trimester human trophoblast, maximal at 7-10
weeks, but declined at 11-12 weeks and remained stable until term. Since reports on
mice have shown that Estrogens play an important role of macrophage MIF, we investigated
the relation of Estrogens and MIF in human placenta.
Methods: Chorionic villous explants were exposed to medium containing 17b-Estradiol
at concentrations varying from 10-5 to 10-12 M or vehicle alone (DMSO 0.1%). At predetermined
times (24, 48, 72 hours) tissues supernatants were collected and assayed by
ELISA for MIF. Tissues were frozen or fixed in formalin for assaying MIF expression
by western blot analysis, real time PCR and immunohistochemistry.
Results: We found that while MIF release is significantly reduced in Estrogens-treated
cultures in a dose-dependent manner, no changes were observed in tissues protein and
mRNA content.
Conclusions: Given the pro-inflammatory role of MIF, the findings suggest that down
regulation of MIF secretion by Estrogens could be an important mechanism to preclude
excessive inflammation in pregnancy
17 beta - Estradiol modulates the macrophage migration inhibitory factor secretory pathway by regulation ABCA1 expression in human first - trimester placenta
No full textSuccessful pregnancy involves a series of events, most of them mediated by hormones and cytokines. Estrogens, besides being important for placental growth and embryo development, have a marked effect on the immune system exerting either pro- or anti-inflammatory properties. Numerous studies suggest that estrogens directly affect cellular function, including cytokine production. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in pregnancy, particularly during the earlier stages of placentation. Since reports on mice have shown that estrogens modulate MIF, herein we investigated the effect of estrogens on human placental MIF. By using an in vitro model of first-trimester chorionic villous explants, we found that 17beta-estradiol (E(2)) was able to modulate the release of MIF in a dose-dependent manner (10(-12) vs. 10(-9) M, P < 0.05; 10(-9) vs. 10(-5) M, P < 0.05; 10(-12) vs. 10(-5) M, P < 0.001). Unlike MIF release, no significant change in tissue MIF protein or MIF mRNA was observed. We showed evidence that E(2) concentrations (10(-9) and 10(-5) M) act on placental tissue downregulating the mRNA and protein expression of the ATP-binding cassette transporter protein A1, a membrane transporter involved in MIF secretion. These findings emphasize the mutual cooperation between hormones and cytokines and suggest that increasing estrogen levels with advancing gestation may have a major role in regulating placental MIF secretion
Effect of COMT functional polymorphism on bias against disconfirmatory evidence in schizophrenia
No full textTheory of mind and stereotypic behavior promote daily functioning in patients with schizophrenia
No full textObjectives: Functional disruption is a main feature of schizophrenia and still represents a major treatment challenge. A more in-depth identification of functional predictors is crucial for the creation of individualized rehabilitation treatments, which can translate into better functional outcomes. In this study, we aimed at pinpointing specific domains that affect different functional profiles, using a data-driven approach. Methods: We included a comprehensive evaluation of functional predictors, namely demographic, cognitive, sociocognitive and clinical variables, with a focus on constituent subdomains of autistic symptoms that have been associated with functioning in the recent literature. Results: In 123 schizophrenia patients, a two-step cluster analysis identified two groups of patients with different functional profiles (low vs high functioning). A backward stepwise logistic regression analysis showed that the odds of being a member of the high functioning group are significantly higher for individuals with (1) more years of education, (2) better Theory of Mind abilities, (3) higher levels of stereotypies/narrowed interests, (4) lower difficulties in social interaction, (5) lower communication difficulties and with (6) being male. Conclusion: Findings raise the intriguing possibility that stereotypic behaviors may have a beneficial effect on functioning in schizophrenia. While the underlying mechanism is currently unknown, we hypothesize that patients may benefit from contexts in which more predictive relationships between environmental entities can systematically be established. This study underscores the potential utility of routinely assessing autistic symptomatology in schizophrenia, which can be instrumental in identifying novel therapeutic targets that can be utilized to improve daily functioning
AIRS D'OPERA / GINO BECHI ; Gino BECHI, baryton
No full textTitre uniforme : [Rigoletto]. ChoixTitre uniforme : [Otello]. ExtraitTitre uniforme : [Don Carlos (1884)]. ExtraitTitre uniforme : [Un ballo in maschera]. ExtraitTitre uniforme : [Guillaume Tell]. Extrait en italienTitre uniforme : [Il barbiere di Siviglia]. ExtraitTitre uniforme : [Pagliacci]. ExtraitComprend : LE BARBIER DE SEVILLE - Acte I "Largo al factotum" / ROSSINI ; avec accomp. d'Orchestre dir. M. CORDONE - PAILLASSE - Prologue : "Si puo... Un nido di memorie" / R. LEONCAVALLO ; avec Orchestre Symphonique de l'Académie Ste Cécile dir. V. BELLEZZA - HERNANI - Acte 3 : "Oh ! Vei verd'anni miei" / Giuseppe VERDI ; avec Orchestre dir. D. OLIVIERI - DON CARLOS - Acte 2 : "Io morro" ("Mort de Rodrigue") / VERDI ; avec Orchestre Symphonique de Milan dir. A. QUADRI - LE BAL MASQUE - Acte 3 : "Eri tu, che macchiavi" / Giuseppe VERDI ; avec l'Orchestre du Théâtre de la Scala de Milan dir. U. BERRETTONI - RIGOLETTO - Acte 1 : "Pari siamo" / Giuseppe VERDI ; Orchestre dir. D. OLIVIERI - RIGOLETTO - Acte 2 : "Cortigiani, vil razza dannata" / Giuseppe VERDI ; Orchestre du Théâtre de la Scala de Milan dir. U. BERRETTONI - OTHELLO - Acte 2 : "Credo in un Dio crudel" / Giuseppe VERDI ; Orchestre dir. M. CORDONI - GUILLAUME TELL - Acte 3 : "Resta immobile" / Gioacchino ROSSINI ; l'Orchestre Symphonique de Milan dir. A. QUADRIBnF-Partenariats, Collection sonore - BelieveContient une table des matière
Enhancing cognitive remediation therapy with transcranial direct current stimulation: preliminary findings in schizophrenia
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