1,721,372 research outputs found
Topical application of 1,25-dihydroxyvitamin-D3 (calcitriol) is an effective and reliable therapy to cure skin-lesions in psoriatic children
No full textWe studied, in vivo, the effects of a calcitriol-containing ointment (3 mug of calcitriol per gram of petrolatum) topically applied on skin lesions in children affected by psoriasis vulgaris. Each patient was instructed to apply the ointment, about 1 g once a day at bedtime followed by occlusive dressing with plastic wrap, on one-side lesion (treated) and petrolatum alone on the equivalent controlateral site (placebo) (total weekly dose of calcitriol: approximately 21 mug/patient). After 4 weeks of topical treatment all children showed a complete clearing of their skin lesions on the treated side, without appreciable changes on the placebo side. Serum ionised calcium, calcium and calcitriol levels or urinary calcium excretion did not vary significantly throughout the period of therapy. These findings suggest that topical calcitriol may be an effective and safe alternative therapy for psoriasis in children
Registries versus tertiary care centers: How do we measure standards of care in Duchenne muscular dystrophy?
No full textIn Duchenne Muscular Dystrophy (DMD), large clinical trials can only be possible as part of an international multicentric effort. A crucial question for the field is whether the centers involved in clinical trials and in natural history studies have similar standards of care, so that comparability of the data is guaranteed and the risk of bias reduced
EDITORIAL. "New and view. Neuromuscular diseases from child to adulthood: new tools and new opportunities"
No full textEditoriale di apertura del volume di Acta Myologica che raccoglie i contributi presentati al convegno dal titolo PROCEEDINGS OF THE XXI CONGRESS OF THE ITALIAN SOCIETY OF MYOLOG
Tissue-specific regulation of the concentration of Calbindin D28K mRNA in the developing chicken
No full textA BamHI-HindIII restriction fragment containing the 5′-terminal portion of the gene encoding chicken Calbindin D28K was sequenced and used as a probe in Northern-blot hydridizations to RNA extracted from the brain and intestine of chickens at various stages of development. In both tissues Calbindin D28K mRNA consists of a family of three species, which differ by size. In the intestine Calbindin D28K mRNAs appear at hatching and reach a peak at day 7. In the brain the same RNA species are easily detected at least 7 days before hatching, show a moderate increase at hatching and remain essentially constant during the first 10 days of adult life. The concentration of Calbindin D28K mRNAs in the intestine is strictly dependent on Vitamin D, while it is not in the cerebellum. © 1989
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