1,721,005 research outputs found
Development of a Novel Class of Pharmacodynamic Hybrids/NO Donors that Targets COX-2 Selectively and a Machine-Assisted Flow Procedure for the Synthesis of Meclinertant, a Neurotensin Receptor Probe
Get PDFThe work described below is divided into two parts.
In the first chapter, the development of a novel class of pharmacodynamic hybrids is discussed. These compounds are endowed with analgesic/anti-inflammatory properties along with their ability to release nitric oxide which makes them an important contribution to the development of effective COX-Inhibiting Nitric Oxide Donors.
In the second chapter, the synthesis of an important neurotensin receptor antagonist (SR 48692, Meclinertant) is described. The synthesis of Meclinertant is achieved with the use of machine-assisted flow protocols through a robust, reliable and scalable route
New heterocyclic compounds with potential activity against parasitic protozoan: Trypanosoma and Leishmania
No full textNew Pyrrole Derivatives as Anti-inflammatory and Analgesic Agents: Design, Synthesis and Biological Evaluation
No full textPyrrole derivatives of BM212 as novel antimycobacterial agents. Design, synthesis, biological evaluation and study of their mode of action
No full textSynthesis and biological evaluation of new heterocyclic derivatives with potential antimycobacterial activity: systematic approach to lead compound optimization
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1,5-Diaryl-Pyrroles as New Generation of Anti-Inflammatory and Analgesic Agents: Design, Synthesis, in vitro and in vivo Evaluation
No full textPyrrole derivatives of BM212 as novel antimycobacterial agents Design, synthesis, biological evaluation and study of their mode of action
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