1,721,312 research outputs found
Aspirin in asymptomatic patients with a confirmed positivity of antiphospholipid antibodies
No full text[No abstract available
FEATURES OF A VIRTUAL LEARNING COMMUNITY IN A BLENDED CORSE OF CLINICAL METHODOLOGY
No full textFor three years, the course of Clinical Methodology for medical students in the third year is being delivered based upon a blend of formal lessons, tutorials and online activities. Besides the availability of resources and self-evaluation tools, the online component of the course encompasses sessions of both synchronous and asynchronous discussion on easy simulations of clinical conditions and basic laboratory or EKG findings. We reviewed the transcripts of the discussion forums to look for the generic features of the virtual communities created during the course and to assess the presence of possible special characteristics of a virtual community of junior medical students. We observed the usual indicators of“social presence”like humor, interactive responses and expressions of mood and noted that social interaction was stronger about organisational topics. On the other hand, focussing on clinical topics produced a high rate of participation but with a lower interaction (i.e. shorter threads). Interaction however, when present, often assumed the traits of “peer support” and of cooperative construction of meaning.
A mechanism that proved to strongly enhance responsiveness was to avoid giving the whole clinical information at the beginning of the simulation but to split it in bits and gradually provide further elements and hints
Inflammation, lipids and cardiovascular risk: The quest for improving risk stratification and prognosis in ischemic heart disease
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[New insights in the pathogenesis of prothrombotic state associated with hypercholesterolemia].
No full textHypercholesterolemia and overt atherosclerotic disorders have been associated with a low-grade inflammation that involves not only the intrinsic cells of the artery wall, but also circulating cells. Platelets as well as monocytes participate importantly in this disease process through the release of a wide variety of biologically active substances. Recent findings on the inflammatory actions of platelets have opened new perspectives in the comprehension of the pathogenetic mechanism(s) of atherosclerosis. Stimulated platelets, in fact, actively synthesize proinflammatory cytokines which have been all involved in the inflammatory process associated to hypercholesterolemia and plaque development. In this context, increasing evidence suggests that interrelated inhibition of inflammation and thrombosis induced by statins could largely contribute to clinical benefits from lipid-lowering therapy
Anticoagulation in patients with atrial fibrillation and chronic kidney disease: clinical complexity beyond thromboembolism
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